Nanometer-sized “drones” that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks
Nanometer-sized “drones” that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks caused by atherosclerosis, according to a study in pre-clinical models by scientists at Brigham and Women’s Hospital (BWH) and Columbia University Medical Center. These findings are published in the February 18th online issue of Science Translational Medicine.
Although current treatments have reduced the number of deaths from atherosclerosis-related disease, atherosclerosis remains a dangerous health problem: Atherosclerosis of the coronary arteries is the #1 killer of women and men in the U.S., resulting in one out of every four deaths. In the study, targeted biodegradable nano ‘drones’ that delivered a special type of drug that promotes healing (‘resolution’) successfully restructured atherosclerotic plaques in mice to make them more stable. This remodeling of the plaque environment would be predicted in humans to block plaque rupture and thrombosis and thereby prevent heart attacks and strokes.
“This is the first example of a targeted nanoparticle technology that reduces atherosclerosis in an animal model,” said co-senior author Omid Farokhzad, MD, associate professor and director of the Laboratory of Nanomedicine and Biomaterials at BWH and Harvard Medical School (HMS). “Years of research and collaboration have culminated in our ability to use nanotechnology to resolve inflammation, remodel and stabilize plaques in a model of advanced atherosclerosis.”
In this study, targeted nanomedicines made from polymeric building blocks that are utilized in numerous FDA approved products to date, were nanoengineered to carry an anti-inflammatory drug payload in the form of a biomimetic peptide. Furthermore, this peptide was derived from one of the body’s own natural inflammatory-resolving proteins called Annexin A1. The way the nanomedicines were designed enabled this biological therapeutic to be released at the target site, the atherosclerotic plaque, in a controlled manner.
In mouse models with advanced atherosclerosis, researchers administered nanomedicines and relevant controls. Following five weeks of treatment with the nanomedicines, damage to the arteries was significantly repaired and plaque was stabilized.
Specifically, researchers observed a reduction of reactive oxygen species; increase in collagen, which strengthens the fibrous cap; and reduction of the plaque necrotic core, and these changes were not observed in comparison with the free peptide or empty nanoparticles.
“Many researchers are trying to develop drugs that prevent heart attacks by tamping down inflammation, but that approach has some downsides,” said co-senior author Ira Tabas, MD, Richard J. Stock professor of Medicine (Immunology) and professor of Pathology & Cell Biology at Columbia. “One is that atherosclerosis is a chronic disease, so drugs are taken for years, even decades. An anti-inflammatory drug that is distributed throughout the entire body will also impair the immune system’s ability to fight infection.” That might be acceptable for conditions that severely affect quality of life, like rheumatoid arthritis, but “using this approach to prevent a heart attack that may never happen may not be worth the risk.”
In addition, it’s not enough to deliver an anti-inflammatory drug to the plaques, said Columbia associate research scientist Gabrielle Fredman, PhD, one of the study’s lead co-authors. “Atherosclerosis is not only inflammation; there’s also damage to the arterial wall. If the damage isn’t repaired, you may not prevent heart attacks.”
The targeted nanomedicines used in this current study were engineered by researchers at BWH. Following preliminary proof-of-principle studies at Columbia University in models of inflammation, they were further tested in a clinically relevant disease model in mice and were shown to be capable of maneuvering through the blood circulation, and traversing leaky regions through to the inside of the plaques, as was demonstrated by fluorescence microscopy imaging of the plaque lesions.
Researchers note that in addition to their specific ‘sticky’ surfaces, their small sub-100 nanometer size is also a key property that facilitates the retention and accumulation of these nanoparticles within the plaques. These nanoparticles are 1000 times smaller than the tip of a single human-hair strand.
“These nanomedicines are developed using biodegradable polymers that can break-up over time in the body using the bodies natural mechanisms, and can be nanoengineered using scale-able chemistries and nanotechnologies, which ultimately can facilitate their rapid translation to the clinic,” said co-lead author Nazila Kamaly, PhD, instructor in the Laboratory of Nanomedicine and Biomaterials at BWH and HMS.
Researchers caution that although plaques in mice look a lot like human plaques, mice do not have heart attacks, so the real test of the nanoparticles will not come until they are tested in humans. “In this study, we’ve shown, for the first time, that a drug that promotes resolution of inflammation and repair is a viable option, when the drug is delivered directly to plaques via nanoparticles,” said Tabas. To be ready for testing in humans, the team plans to fine-tune the nanoparticles to optimize drug delivery and to package them with more potent resolution-inducing drugs. “We think that we can obtain even better delivery to plaques and improve healing more than with the current peptides,” , he said.
The Latest on: Nanodrones
via Google News
The Latest on: Nanodrones
- Nano Drones Market: Expected To Grow At The Highest CAGR During The Forecast Period 2018 - 2026on November 26, 2019 at 4:34 am
Drones, also called Unmanned Aerial Vehicles (UAVs) are remote-controlled aircraft that range from hand-operated systems to long endurance, high altitude systems similar in operation to small aircraft ...
- Army Sees Lasers, Hoverbikes and Nano Drones in Future Forceon November 17, 2019 at 4:00 pm
Nano drones have also gained quite a bit of attention following the Army's announcement that it had launched the Soldier Borne Sensors (SBS) program, which includes a drone that weighs less than a ...
- Tata Power to use nano drones for network maintenance in Delhion August 9, 2019 at 12:03 pm
Tata Power Delhi Distribution Limited is planning to introduce drones in a measure to monitor transmission and distribution networks to detect faults. Watch full video to know more.
- Researchers design nanodrone to detect toxic gases in emergencieson July 23, 2019 at 12:01 pm
A drone is an aircraft -civil or military- piloted by remote control. In this sector of technology, which is constantly expanding around its multiple fields of application, nanodrones are operational ...
- Nano Drones Market is Booming Worldwide | AeroVironment, Parrot, JJRC Toy, Prox Dynamics, Skyrocket Toys, Syma Toyson July 21, 2019 at 9:29 pm
Jul 22, 2019 (AB Digital via COMTEX) -- A new business intelligence report released by HTF MI with title "Global Nano Drones Market Research Report 2012-2024" has abilities to raise as the most ...
- Find out Why Nano Drones Market Is Thriving Worldwideon June 10, 2019 at 2:43 am
Jun 10, 2019 (Heraldkeeper via COMTEX) -- Due to increasing applications of drone technology in logistics applications, growing demand for nano drones from the live streaming events as well as ...
- Global Biomimetic Technology Market 2018-2028: Focus on Medical & Robotics - Increasing Demand for Biomimetic Nano Droneson March 8, 2019 at 3:50 pm
The global biomimetic technology market was valued at $6.80 billion in 2017 Rising demand for biomimetic nano drones for search and rescue, surveillance, and biomimetic technologies in medical ...
- FLIR nano-drones are now able to be automatically launched from vehicleson October 8, 2018 at 7:19 am
FLIR Systems has shared that its Black Hornet 3 nano-drones can be packed into a launch unit that allows for deployment of multiple units in rapid succession. The military-focused drones are used for ...
- Nano-Drones Are the Perfect Tool to Create Original Videoson August 2, 2018 at 10:12 am
Nano-drones are usually designed as indoor toys but they can be used to create some very unique shots. Thanks to their small sizes, these tiny quadcopters can fly in very tight spaces and create ...
- Global $2+ Billion Commercial Drones (Rotary Blade Drones, Hybrid Drones, Nano Drones & Fixed Wing Drones) Market 2017-2022on November 17, 2017 at 4:31 pm
Segmentation By Type Rotary Blade Drones Hybrid Drones Nano Drones Fixed Wing Drones By Industry Vertical Energy Agriculture Retail Media and Entertainment Government Others Key industry players are ...
via Bing News