When UC Berkeley bioengineers say they are holding their hearts in the palms of their hands, they are not talking about emotional vulnerability
Instead, the research team led by bioengineering professor Kevin Healy is presenting a network of pulsating cardiac muscle cells housed in an inch-long silicone device that effectively models human heart tissue, and they have demonstrated the viability of this system as a drug-screening tool by testing it with cardiovascular medications.
This organ-on-a-chip, reported in a study published today (Monday, March 9) in the journal Scientific Reports, represents a major step forward in the development of accurate, faster methods of testing for drug toxicity. The project is funded through the Tissue Chip for Drug Screening Initiative, an interagency collaboration launched by the National Institutes of Health to develop 3-D human tissue chips that model the structure and function of human organs.
“Ultimately, these chips could replace the use of animals to screen drugs for safety and efficacy,” said Healy.
The study authors noted a high failure rate associated with the use of nonhuman animal models to predict human reactions to new drugs. Much of this is due to fundamental differences in biology between species, the researchers explained. For instance, the ion channels through which heart cells conduct electrical currents can vary in both number and type between humans and other animals.
“Many cardiovascular drugs target those channels, so these differences often result in inefficient and costly experiments that do not provide accurate answers about the toxicity of a drug in humans,” said Healy. “It takes about $5 billion on average to develop a drug, and 60 percent of that figure comes from upfront costs in the research and development phase. Using a well-designed model of a human organ could significantly cut the cost and time of bringing a new drug to market.”
The Latest on: Organ-on-a-chip
via Google News
The Latest on: Organ-on-a-chip
- MIT Develops New Model for Organs-on-a-Chip And Drug Researchon April 3, 2020 at 7:02 am
These types of devices can be instrumental in analysing and potentially creating new treatments for complex diseases. Creating an organ-on-a-chip has helped the MIT research team to examine how the ...
- Organs On Chips Will Make Drugs Safer—And More Preciseon March 29, 2020 at 5:00 pm
That’s the year the Defense Advanced Research Projects Agency (DARPA), the U.S. Food and Drug Administration (FDA), and the National Institutes of Health (NIH) partnered to form a collaboration to ...
- Novel multi-organ-on-a-chip system could revolutionize drug developmenton March 27, 2020 at 11:12 am
Researchers have developed a novel multi-organ-on-a-chip that can demonstrate toxicity more accurately than standard methods. Current drug testing practices have resulted in a large number of drugs ...
- Organ-on-a-chip Systems Market Emerging Trend,Growth,Revenue 2026| TissUse, Hesperos, CN Bio Innovationson March 27, 2020 at 1:58 am
Complete study of the global Organ-on-a-chip Systems market is carried out by the analysts in this report, taking into consideration key factors like drivers, challenges, recent trends, opportunities, ...
- Cornea-on-a-chip simulates blinking of the eyeon March 25, 2020 at 9:05 am
While scientists have successfully produced various "organ-on-a-chip" models of body parts, the eye is particularly challenging, as a tear film is regularly moved across its surface as we blink. That ...
- Vienna: 3D printing Prototypes for Cutting the Cost of Lab-on-a-Chip & Organ-on-a-Chip Systemson March 24, 2020 at 5:00 pm
The researchers sought out cells and organ-on-a-chip concepts that could be created in both 2D and 3D, along with those that would offer biocompatible materials; after all, in the end, when it ...
- Emulate Taps PerkinElmer’s Corbett as CEO, Gets Cash for Commercial Pushon March 23, 2020 at 11:03 am
“Organ-on-a-chip” startup Emulate has appointed Jim Corbett to serve as its new CEO. Corbett joins the Boston-based company from PerkinElmer, where he was executive vice president and ...
- Stem cells and nerves interact in tissue regeneration and cancer progressionon March 23, 2020 at 10:27 am
Using the "organ-on-a-chip" technology, which relies on small three-dimensional devices mimicking the basic functions of human organs and tissues, the researchers demonstrated that both types of ...
- ‘Organ-on-a-chip’ maker Emulate names new CEO, announces new fundingon March 19, 2020 at 10:21 am
A Boston startup known for its plastic chips that simulate human organs announced the appointment of a new CEO on Thursday as it ramps up its commercial portfolio with new funding. STAT Plus is ...
- Drug Toxicity Screening May Get a Boost from New Organ-on-a-Chip Systemon March 2, 2020 at 1:38 pm
Scientists from the Wake Forest School of Medicine and Ohio State University say they have developed a new multi-organ-on-a-chip to test how new drugs affect the human body’s vital organs.
via Bing News