Scientists are a step closer to developing a pill to cure dementia.
A team in Belgium were able to repair diseased brain cells taken from patients with a common form of the condition, for which there is no cure.
They identified a gene variant that prevents neurons from forming properly, and managed to correct it through genetic engineering.
The researchers found they could also correct alter the gene a compound that inhibited a chemical responsible for the gene mutation.
They have hailed the discovery a breakthrough, believing it could pave the way for a new ‘dementia pill’.
The study used stem cells from three patients with a type of dementia called ‘frontotemporal dementia’, which accounts for about half of cases diagnosed in patients before the age of 60.
There is currently no cure for this type of the condition, which runs in families.
Frontotemporal disorders are the result of damage to neurons in parts of the brain called the frontal and temporal lobes, gradually leading to behavioural symptoms or language and emotional problems.
Mutations in a gene called GRN (progranulin) are believed to be behind frontotemporal dementia, but versions of the condition in mice do not mimic all the features of the human type.
So the Belgian researchers recreated dementia in a laboratory dish using human iPSCs (induced pluripotent stem cells) to help identify a potential new treatment strategy.
Molecular biologist Professor Catherine Verfaillie, of the Catholic University of Leuven, said: ‘Use of induced pluripotent stem cell technology makes it possible to model dementias that affect people later in life.’
The technique involves taking skin cells from patients and reprogramming them into embryonic like stem cells capable of turning into other specific cell types relevant for studying a particular disease.
The Latest on: Dementia pill
via Google News
The Latest on: Dementia pill
- Nonprofit celebrates dementia patients’ mindson July 5, 2019 at 1:21 am
The organization strives to provide treatment “beyond a pill” by offering “dignifying, engaging and person-centric services” while stepping away from bingo and other traditional measures. According to ... […]
- Dementia medication ‘underused’ in aged care facilitieson July 4, 2019 at 2:18 pm
A study has found low rates of dementia medication in Australian aged care facilities compared to other countries including the US, the UK and Denmark. The study, Antidementia medication use by aged ... […]
- What are anticholinergic drugs and is there a link to dementia?on July 3, 2019 at 9:30 am
An observational study released recently linked dementia in seniors with the usage ... which is equivalent to taking a strong anticholinergic medication daily for at least three years. ... […]
- Can These Common Meds Give You Dementia?on July 1, 2019 at 2:08 pm
If the cause-and-effect relationship is confirmed, then around 10% of dementia cases could be attributed to popping anticholinergic pills, which is more than other risk factors, including diabetes, ... […]
- Nursing homes are giving Alzheimer's patients baby dolls as a form of therapyon July 1, 2019 at 12:27 pm
The research around dolls and Alzheimer's disease is far from conclusive, but a number of studies suggest the dolls can can improve communication and reduce the need for psychotropic medication, ... […]
- Antipsychotic Use in Dementia Linked To Increased Mortalityon July 1, 2019 at 12:00 pm
In a Danish registry study of almost 33,000 patients with dementia, those who received an antipsychotic drug had a 35% increased risk of mortality compared with their peers who did not receive this ... […]
- Commonly prescribed drugs tied to nearly 50% higher dementia risk in older adults, study sayson July 1, 2019 at 7:22 am
The study--published in the Journal of the American Medical Association--found the risk of getting dementia increased nearly 50 percent for patients who took medication every day for at least three ... […]
- Why the Discovery of ‘LATE’ Dementia Is Importanton July 1, 2019 at 5:13 am
what can you do if you suspect a loved one may have LATE rather than Alzheimer’s dementia? If you feel that person isn’t responding well to a medication for Alzheimer’s, don’t be afraid to question ... […]
- Do you know the connection between blood pressure and Alzheimer’s?on June 29, 2019 at 9:25 pm
High blood pressure can cause damage to the small blood vessels in the brain, affecting parts of the brain that are responsible for thinking and memory. According to a recent report, blood pressure ... […]
- A pill to boost your memory? Forget iton June 28, 2019 at 4:01 pm
Taking supplements to boost your brain and fight dementia may sound like a clever thing to do but could be a waste of money. A report says that there is “no convincing evidence” that nutritional ... […]
via Bing News