Associate Professor Ki-Bum Lee has developed patent-pending technology that may overcome one of the critical barriers to harnessing the full therapeutic potential of stem cells.
One of the major challenges facing researchers interested in regenerating cells and growing new tissue to treat debilitating injuries and diseases such as Parkinson’s disease, heart disease, and spinal cord trauma, is creating an easy, effective, and non-toxic methodology to control differentiation into specific cell lineages. Lee and colleagues at Rutgers and Kyoto University in Japan have invented a platform they call NanoScript, an important breakthrough for researchers in the area of gene expression. Gene expression is the way information encoded in a gene is used to direct the assembly of a protein molecule, which is integral to the process of tissue development through stem cell therapeutics.
Stem cells hold great promise for a wide range of medical therapeutics as they have the ability to grow tissue throughout the body. In many tissues, stem cells have an almost limitless ability to divide and replenish other cells, serving as an internal repair system.
Transcription factor (TF) proteins are master regulators of gene expression. TF proteins play a pivotal role in regulating stem cell differentiation. Although some have tried to make synthetic molecules that perform the functions of natural transcription factors, NanoScript is the first nanomaterial TF protein that can interact with endogenous DNA. ACS Nano, a publication of the American Chemical Society (ACS), has published Lee’s research on NanoScript. The research is supported by a grant from the National Institutes of Health (NIH).
“Our motivation was to develop a highly robust, efficient nanoparticle-based platform that can regulate gene expression and eventually stem cell differentiation,” said Lee, who leads a Rutgers research group primarily focused on developing and integrating nanotechnology with chemical biology to modulate signaling pathways in cancer and stem cells. “Because NanoScript is a functional replica of TF proteins and a tunable gene-regulating platform, it has great potential to do exactly that. The field of stem cell biology now has another platform to regulate differentiation while the field of nanotechnology has demonstrated for the first time that we can regulate gene expression at the transcriptional level.”
NanoScript was constructed by tethering functional peptides and small molecules called synthetic transcription factors, which mimic the individual TF domains, onto gold nanoparticles.
“NanoScript localizes within the nucleus and initiates transcription of a reporter plasmid by up to 30-fold,” said Sahishnu Patel, Rutgers Chemistry graduate student and co-author of the ACS Nano publication. “NanoScript can effectively transcribe targeted genes on endogenous DNA in a nonviral manner.”
The Latest on: Stem Cell Therapeutics
via Google News
The Latest on: Stem Cell Therapeutics
- Google bans ads for 'unproven' therapies, including stem cellson September 8, 2019 at 2:56 pm
Google says it is banning online ads for unproven medical treatments including most stem cell and gene therapy. "This new policy will prohibit ads selling treatments that have no established ...
- Elk Grove Man Selling Memorabilia to Help Pay for Stem Cell Therapyon September 7, 2019 at 2:44 am
ELK GROVE -- A few years ago, a young Elk Grove father turned to social media to fundraise for a family friend whose son needed a heart transplant. As someone who steps up when others are in need, ...
- Google ends stem cell therapy ads due to “rise of bad actors”on September 6, 2019 at 2:19 pm
Some say the modern version of snake oil is unproven stem cell treatments, and Google is cracking down on these types of treatments advertising on its site. Continue Reading Below "A rise in bad ...
- Google will stop selling ads for untested stem cell therapieson September 6, 2019 at 11:36 am
“I think it’s a very meaningful step in not allowing these frivolous ads,” said Sunil Abhyankar, the director of the Midwest Stem Cell Therapy Center at the University of Kansas Medical Center. “Those ...
- Google bans ads for 'unproven or experimental medical techniques' like stem cell therapyon September 6, 2019 at 10:05 am
Google on Friday announced a new healthcare and medicines policy that bans advertising for "unproven or experimental medical techniques," which it says contains stem cell, cellular and gene therapies.
- New Google policy bars ads for unproven stem cell therapieson September 6, 2019 at 9:04 am
Stem cell clinics multiply, with heartbreaking results for some patients. What you should know about stem cells, from promising research to dubious uses 'Miraculous’ stem cell therapy has sickened ...
- R3 Stem Cell On The Future Of Stem Cell Therapy Treatmentson September 5, 2019 at 11:27 pm
Stem cell therapy is regenerating and restoring the health of patients afflicted with various chronic ailments worldwide. Patients seeking pain relief along with an increased quality of life have been ...
- Breast cancer: Hormone therapy may only put some cells to 'sleep'on September 4, 2019 at 6:58 pm
Why does breast cancer sometimes recur after treatment? A new study suggests that in part, the answer may lie in the effect of adjuvant hormone therapy on some cancer cells. "For a long time ...
- Stem cell therapy for Osteoarthritison September 4, 2019 at 6:10 pm
Innovations Medical has locations in Dallas, Frisco and Fort Worth. Call (214) 972-0353 or (817) 873-2885 for more information. You can also log onto www.innovationsmedical.com.
- Global Stem Cell Therapy Market to Reach $11 Billion by 2029: BIS Researchon September 4, 2019 at 4:30 am
FREMONT, California, Sept. 4, 2019 /PRNewswire/ -- According to a recent market intelligence report by BIS Research titled "Global Stem Cell Therapy Market- Analysis and Forecast, 2018-2029", the ...
via Bing News