Chemists have developed a revolutionary new way to manufacture natural chemicals by clipping smaller molecules together like Lego. They have used the new method to assemble a scarce anti-inflammatory drug with potential to treat cancer and malaria, pseudopterosin.
“We took small molecules and clipped them together like Lego,” said lead researcher Professor Michael Sherburn, from the Research School of Chemistry.
“The building blocks are carefully designed in such a way that the first reaction generates a product perfectly primed for the second. It’s quite magical. This means you can efficiently build large and complex molecules.”
Medicines of this type have traditionally been made in a cumbersome way. Chemists take a related molecule and renovate it. This is a lengthy process, with unwanted structural features being ripped out and replaced.
“This leads to a lot of waste,” Professor Sherburn said.
The group trialed their innovative new method by making pseudopterosin, a powerful anti-inflammatory and analgesic drug, which is currently only available in tiny quantities extracted from fan coral found in the Bahamas.
The work began as blue-sky research, with the researchers trying to work out a way to make supposedly impossible molecules of cross-conjugated hydrocarbons.
Before trying the experiments the team ran simulations on the Raijin supercomputer, which indicated that their method had potential.
“Ours is an empowering and enabling technique, allowing a smarter and faster way to make important substances,” said Dr Chris Newton, who did the research in the laboratory as a PhD student.
The Latest on: Manufacturing new drugs
via Google News
The Latest on: Manufacturing new drugs
- Former FDA leaders decry emergency authorization of malaria drugs for coronaviruson April 7, 2020 at 3:25 pm
EUAs might prove crucial in the new pandemic, but only if credible ... a leading Indian maker of the drugs. FDA has repeatedly cited the company for manufacturing lapses, most recently in a scathing ...
- Philadelphia drug maker poised to ramp up production of possible COVID-19 therapyon April 7, 2020 at 12:42 pm
Philadelphia-based Lannett is poised to ramp up production of a drug WHO is testing as a possible COVID-19 therapy.
- New Coronavirus Drug Shows Promise in Animal Testson April 7, 2020 at 11:09 am
Workers make face masks to meet their demands in view of the spread of novel coronavirus pandemic on day thirteen of the 21-day nationwide lockdown to check the spread of coronavirus at a private ...
- Supplies of some drugs used to treat coronavirus patients are running low in N.J.on April 7, 2020 at 11:05 am
Some 3D printers have taken a stab at ventilators and face shields. But regulations in the drug manufacturing industry don’t allow such an easy shift, and it often takes years before producers can add ...
- Human Insulin Drugs & Delivery Devices Market 2020 Global, Size, Trends, Demand and Share Analysis to 2025on April 7, 2020 at 10:57 am
New York, April 07, 2020: The Global Human Insulin Drugs & Delivery Devices Market is expected to exceed more than US$ ...
- At 8.28%, Drug Discovery Market: Opportunities And Forecast Assessment, 2020-2027on April 7, 2020 at 9:56 am
Market Study Report adds global Drug Discovery Market report that gives meticulous investigation of current scenario of the ...
- Gilead Partners Second Genome, Boosts Coronavirus Drug Productionon April 7, 2020 at 8:45 am
Gilead (GILD) collaborates with Second Genome for inflammatory bowel disease treatments. The company also plans to ramp up production of remdesivir for coronavirus treatment.
- Hydroxychloroquine drug trial underway at UW but can it tame COVID-19?on April 7, 2020 at 7:15 am
On Monday, scientists at the University of Washington started their second week of trials to determine if h can prevent the spread of the coronavirus. "We've been able to enroll participants, but we ...
- Covid-19 Could Bring Generic Drug Manufacturing Back to the U.S., Analyst Writeson April 7, 2020 at 6:46 am
the Covid-19 crisis could result in generic drug makers bringing manufacturing back to the U.S. from India and China, where it is heavily concentrated. “The concern about the dependency of the US ...
- Controversial drug hydroxychloroquine to be given to coronavirus patients in Australiaon April 7, 2020 at 12:41 am
A controversial anti-malaria drug will be given to Australian Covid-19 patients in hospitals outside of clinical trials, the federal government confirmed, after the therapeutic goods registration ...
via Bing News