For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers from the University of Waterloo have developed a topical solution containing nanoparticles that will combat dry eye syndrome with only one application a week.
The eye drops progressively deliver the right amount of drug-infused nanoparticles to the surface of the eyeball over a period of five days before the body absorbs them. One weekly dose replaces 15 or more to treat the pain and irritation of dry eyes.
The nanoparticles, about 1/1000th the width of a human hair, stick harmlessly to the eye’s surface and use only five per cent of the drug normally required.
“You can’t tell the difference between these nanoparticle eye drops and water,” said Shengyan (Sandy) Liu, a PhD candidate at Waterloo’s Faculty of Engineering, who led the team of researchers from the Department of Chemical Engineering and the Centre for Contact Lens Research. “There’s no irritation to the eye.”
Dry eye syndrome is a more common ailment for people over the age of 50 and may eventually lead to eye damage. More than six per cent of people in the U.S. have it. Currently, patients must frequently apply the medicine three times a day because of the eye’s ability to self-cleanse—a process that washes away 95 per cent of the drug.
“I knew that if we focused on infusing biocompatible nanoparticles with Cyclosporine A, the drug in the eye drops, and make them stick to the eyeball without irritation for longer periods of time, it would also save patients time and reduce the possibility of toxic exposure due to excessive use of eye drops,” said Liu.
The research team is now focusing on preparing the nanoparticle eye drops for clinical trials with the hope that this nanoparticle therapy could reach the shelves of drugstores within five years.
For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers from the University of Waterloo have developed a topical solution containing nanoparticles that will combat dry eye syndrome with only one application a week.
The eye drops progressively deliver the right amount of drug-infused nanoparticles to the surface of the eyeball over a period of five days before the body absorbs them. One weekly dose replaces 15 or more to treat the pain and irritation of dry eyes.
The Latest on: Drug-infused nanoparticle
High-tech gel aids delivery of drugs - Science Daily
August 28, 2019 - High-tech gel aids delivery of drugs Science DailyDrugs that help prevent the formation of unwanted or harmful proteins are currently being developed to treat a number of diseases, including cancer. The drugs ...
August 26, 2019 - Quest for new cancer treatment crosses milestone: Therapy excels in pilot clinical trials Science DailyA cancer therapy has crossed a milestone in clinical trials, a major development in a decades-long quest to develop a treatment that destroys tumors without the ...
Nanoscale 'glass' bottles could enable targeted drug delivery - Science Daily
August 15, 2019 - Nanoscale 'glass' bottles could enable targeted drug delivery Science DailyTiny silica bottles filled with medicine and a special temperature-sensitive material could be used for drug delivery to kill malignant cells only in certain parts of ...
Nanoscale “Glass” Bottles Could Enable Targeted Drug Delivery - Georgia Tech News Center
August 14, 2019 - Nanoscale “Glass” Bottles Could Enable Targeted Drug Delivery Georgia Tech News CenterTiny silica bottles filled with medicine and a special temperature-sensitive material could be used for drug delivery to kill malignant cells only in certain parts of ...Nanotech turns pro-tumor immune cells into cancer-killing triple agents - Fred Hutch News Service
September 6, 2019 - Nanotech turns pro-tumor immune cells into cancer-killing triple agents Fred Hutch News ServiceDissolving nanoparticles that ferry temporary genetic instructions to immune cells can extend survival, up to twice as long, in mice with ovarian, brain and skin ...
Nanospectra's Nanoparticle Light Therapy for Prostate Cancer Shows Promise - BioSpace
August 27, 2019 - Nanospectra's Nanoparticle Light Therapy for Prostate Cancer Shows Promise BioSpaceAuroLase Therapy is a focal ablation treatment utilizing gold nanoparticles. The nanoparticles heat and destroy cancer cells.Tiny 'glass' bottles deliver drugs at right temp and place - Futurity: Research News
August 16, 2019 - Tiny 'glass' bottles deliver drugs at right temp and place Futurity: Research NewsNanoscale silica bottles filled with medicine and a temperature-sensitive material could one day deliver drugs to kill malignant cells only in certain parts of the ...Seeking Small Molecule Drugs to Control mRNA Translation - BioSpace
August 27, 2019 - Seeking Small Molecule Drugs to Control mRNA Translation BioSpaceWouldn't it be amazing to be able to see a protein being made in a cell in real time? And wouldn't it be even better if you could use that capability to discover ...Gold nanoparticles used successfully in prostate tumour trial - News-Medical.net
August 28, 2019 - Gold nanoparticles used successfully in prostate tumour trial News-Medical.netResearchers at the Icahn School of Medicine, Mount Sinai, New York have reported a pilot clinical trial with a “nanoparticle-based photothermal cancer therapy” ...
- August 27, 2019 - World Therapeutic Drug Monitoring (TDM) Market Outlook to 2028 with Market Values in Major Regions PRNewswireDUBLIN, Aug. 27, 2019 /PRNewswire/ -- The "Therapeutic Drug Monitoring - Technologies, Markets & Companies" report from Jain PharmaBiotech has been ...
via Google News
The Latest on: Drug-infused nanoparticle
- High-tech gel aids delivery of drugson August 28, 2019 at 12:35 pm
But systemically delivered nanoparticle-incorporated drugs tend ... or drugs directly to specific areas in the body. A drug-infused hydrogel plug or sheet can be placed directly where the drug ...
- Drug-infused hydrogel coatings add firepower to nanoshell cancer treatmenton July 15, 2019 at 5:00 pm
Building on previous work, researchers at Duke University have developed a new technology that wraps nanoshells in a thin film of drug-infused hydrogel, adding additional firepower to the already ...
- Scientists Develop Experimental “Nano-Chemo” Particle to Treat Bladder Canceron October 16, 2017 at 6:13 am
The team of investigators from the Brady Urological Institute and the Center for Nanomedicine at Johns Hopkins, engineered the nanoparticles from biologically compatible materials, such as ...
- Nanoparticle drug-delivery method holds promise for controlling crop parasiteson May 30, 2017 at 5:00 pm
In testing with the nematode Caenorhabdiis elegans, in a liquid culture, the scientists confirmed that nematodes were paralyzed and killed by treatment with the drug-infused virus-nanoparticle – this ...
- Nanoparticle drops to combat dry eye syndromeon October 8, 2014 at 5:00 pm
The eye drops progressively deliver the right amount of drug-infused nanoparticles to the surface of the eyeball over a period of five days before the body absorbs them. One weekly dose replaces 15 or ...
- Drug-infused nanoparticle is right for sore eyeson October 7, 2014 at 5:00 pm
For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers from the University of ...
- Drug-infused nanoparticle is right for sore eyeson October 7, 2014 at 5:00 pm
For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers have developed a topical ...
- Stealthy Nanoparticles Attack Cancer Cellson November 3, 2009 at 4:00 pm
The vats are designed to violently shake a mix of chemicals into precise nanostructures, and Troiano’s task, as head of process development at start-up BIND Biosciences, is to make kilograms of the ...
- Drug-Infused Nanoparticles Stop Cancer From Spreadingon July 13, 2008 at 5:00 pm
In an experiment described today in the Proceedings of the National Academy of Sciences, researchers led by University of California, San Diego pathologist David Cheresh designed nanoparticles that ...
via Bing News
