A potential breakthrough in techniques to develop drugs to treat diseases as diverse as cancer and Alzheimer’s has been reported by chemists at the University of Leicester in the UK.
The Jamieson Research Group in the Department of Chemistry at the University of Leicester claim to have developed a new process for generating a specific synthetic amino acid.
Amino acids are used to make all proteins – the Leicester team refers to them as “Mother Nature’s building blocks,” as they are essential for life.
“We are very proud of this research,” says lead scientist Dr. Andrew Jamieson, “it has taken several years of hard work to master the chemistry techniques to create these new building blocks, but now that we have conquered it, we have access to new building blocks that people have only ever dreamed of before!”
There are 20 naturally produced amino acids in total. By contrast, the new chemical synthesis of unnatural amino acids pioneered by the Leicester team could be used to make designer mini-proteins with entirely new structures and functions from those found in nature.
Dr. Jamieson explains:
“Unnatural amino acids, the building blocks, are described as chiral, meaning they have ‘handedness.’ A robust synthesis to selectively produce molecules with a particular handedness has not previously been reported. Our new practical method allows us to selectively synthesize only the ‘right handed molecules.’
This new research is important because it has uncovered a new, easier and quicker way to make these building blocks which can be used to make new drugs. We now have access to new building blocks to develop innovative new protein drugs for the treatment of disease.”
Dr. Jamieson mentions that a student also used the building blocks to synthesize a toxin produced by a sea snail, which the team hopes to develop as a new painkiller.
The Latest on: Designer proteins
via Google News
The Latest on: Designer proteins
- Sibe: a computation tool to apply protein sequence statistics to predict folding and design in silicoon September 6, 2019 at 10:16 am
Evolutionary information contained in the amino acid sequences of proteins specifies the biological function and fold, but exactly what information contained in the protein sequence drives both of ...
- Plasma Protein Therapeutics Market Future Scope and Growth Factors 2019 - 2025: CSL, Grifols, Octapharmaon September 6, 2019 at 9:50 am
Plasma Protein Therapeutics is widely used to treat Hemophilia ... QYResearch consulting group has accumulated creative design methods on many high-quality markets investigation and research team with ...
- Hormel unwraps plant-based protein line, called Happy Little Plantson September 5, 2019 at 6:45 am
[Most read] Cubs co-owner Todd Ricketts’ property tax assessment appeal on designer Wilmette home sent to state ... as it is meeting the consumers' culinary needs and packed with protein," he said.
- Lundbeck chooses Discngine’s 3decision platform for handling complex protein-ligand 3D structure dataon September 5, 2019 at 5:52 am
Financial details of the agreement are not disclosed. Today, rational structure-based drug design (SBDD) techniques are used in the majority of drug discovery projects. However, inconsistent data and ...
- Mackie: Female athletes require more protein than previously thoughton September 4, 2019 at 1:14 pm
The protein source was, “a crystalline amino acid modeling egg ... and performance training protocols that are male oriented. The idea that one size or design fits all – males and females – does an ...
- Gyros Protein Technologies introduces PurePep Chorus automated peptide synthesizeron September 3, 2019 at 11:00 pm
Jasmine Gruia-Gray, SVP Marketing, Gyros Protein Technologies, said: “This latest instrument harnesses the power of our proprietary PurePep Pathway in a modular design, maximizing purity and ...
- Major grant strengthens leading Danish position in protein researchon September 3, 2019 at 7:12 am
The Center's research programs are all contributing to this joint effort through big data analysis of thousands of patients, rational drug design through protein structure and mechanistic ...
- New Data on Structure, Function of SARM1 Protein May Aid Design of ALS Therapieson August 29, 2019 at 5:00 am
Disarm Therapeutics has announced the publication of two studies that further researchers’ understanding of the structure and function of SARM1, a key protein in cellular degeneration. The new data ...
- Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificityon August 28, 2019 at 11:19 am
5 Centre of Membrane Proteins and Receptors, University of Birmingham, Birmingham B15 2TT, UK. 6 Shenzhen Bay Laboratory and Laboratory of Computational Chemistry and Drug Design, Peking University ...
- Construct design, gene synthesis, and personal foundry, all in a single platform: an interview with Doulixon August 26, 2019 at 6:20 am
His work in synthetic biology includes development of methods for protein and RNA degenerated libraries design and construction, modular protein-based nanomaterials for tissue regeneration and ...
via Bing News