Experimental therapy stopped the metastasis of breast and ovarian cancers in lab mice, pointing toward a safe and effective alternative to chemotherapy.
A team of Stanford researchers has developed a protein therapy that disrupts the process that causes cancer cells to break away from original tumor sites, travel through the bloodstream and start aggressive new growths elsewhere in the body.
This process, known as metastasis, can cause cancer to spread with deadly effect.
“The majority of patients who succumb to cancer fall prey to metastatic forms of the disease,” said Jennifer Cochran, an associate professor of bioengineering who describes a new therapeutic approach in Nature Chemical Biology.
Today doctors try to slow or stop metastasis with chemotherapy, but these treatments are unfortunately not very effective and have severe side effects.
The Stanford team seeks to stop metastasis, without side effects, by preventing two proteins – Axl and Gas6 – from interacting to initiate the spread of cancer.
Axl proteins stand like bristles on the surface of cancer cells, poised to receive biochemical signals from Gas6 proteins.
When two Gas6 proteins link with two Axls, the signals that are generated enable cancer cells to leave the original tumor site, migrate to other parts of the body and form new cancer nodules.
To stop this process Cochran used protein engineering to create a harmless version of Axl that acts like a decoy. This decoy Axl latches on to Gas6 proteins in the bloodstream and prevents them from linking with and activating the Axls present on cancer cells.
In collaboration with Professor Amato Giaccia, who leads the Radiation Biology Program in the Stanford Cancer Center, the researchers gave intravenous treatments of this bioengineered decoy protein to mice with aggressive breast and ovarian cancers.
Mice in the breast cancer treatment group had 78 percent fewer metastatic nodules than untreated mice. Mice with ovarian cancer had a 90 percent reduction in metastatic nodules when treated with the engineered decoy protein.
“This is a very promising therapy that appears to be effective and nontoxic in preclinical experiments,” Giaccia said. “It could open up a new approach to cancer treatment.”
The Latest on: Alternative to chemotherapy
via Google News
The Latest on: Alternative to chemotherapy
- Marvellous Milli Lucas returns to Perth after cancer treatment in Germanyon July 23, 2019 at 1:53 am
After a brief stay at home following her return from Sydney last month, Milli set off for Bochum, Germany with her family to begin alternative treatment. In June her mother, Ms Smirk, said Milli would ... […]
- Marker Therapeutics Provides More Upbeat Data On Weekend To Clarify TACTOPS Trial Dataon July 22, 2019 at 7:55 am
Multi TAA also demonstrated efficacy in patients that were chemo refractory and thus had no other alternatives. Investors have been anxiously awaiting the results by Marker Therapeutics of their ... […]
- Immune cell therapy shows early promise for patients with pancreatic canceron July 22, 2019 at 5:32 am
"Most patients have intense chemotherapy, which often has severe adverse effects, and we urgently need alternative approaches to treatment. "We are encouraged by the early results suggesting that ... […]
- Data Points to Cannabis Emergence as a Viable Part of Cancer Treatmenton July 19, 2019 at 6:05 am
As a result, more medical institutions are beginning to recommend cannabis as an alternative to treat the adverse associated ... can be helpful in treating the side effects of cancer chemotherapy. A ... […]
- Second breast cancer treatment combo added to England's Cancer Drugs Fundon July 17, 2019 at 9:07 am
NICE concluded that the combination treatment could delay the need for chemotherapy in those patients with aggressive ... “The treatment offers an alternative to a different drug combination approved ... […]
- A Protein Explains Why Some Cancers Resist Chemotherapyon July 16, 2019 at 10:41 am
More immediately, however, it could identify cases where resistance is likely to occur, offering an opportunity to use alternative treatments. 5-Fluorouracil (5-FU) is the most used chemotherapy ... […]
- The Side Effects of Chemotherapy: Here’s What to Expecton July 15, 2019 at 12:16 pm
Chemotherapy is one of the original cancer treatments ... There are medications available to mitigate these unpleasant side effects, and there are also alternative approaches, such as medical ... […]
- Local volunteer drivers needed to take cancer patients to medical treatmenton July 15, 2019 at 2:08 am
“A patient receiving chemotherapy might report for treatment weekly for up to a year. In many cases, a patient is driven to hospitals or clinics by relatives or friends, but even these patients must ... […]
- 3-drug combo may offer alternative to chemo for bowel cancer patientson July 15, 2019 at 1:11 am
PanARMENIAN.Net - Chemotherapy treatment for people who have advanced bowel cancer and a particular genetic mutation is commonly ineffective. A combination of three different drugs could be the key to ... […]
- Bowel cancer: 3-drug combo may offer alternative to chemoon July 14, 2019 at 3:07 am
Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current ... […]
via Bing News