New valves may grow with patients and may have lower rejection rates
Researchers have found a way to take a pediatric patient’s skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve. A proof of concept study in the September 2014 issue of The Annals of Thoracic Surgery provides more detail on this scientific development.
“Current valve replacements cannot grow with patients as they age, but the use of a patient-specific pulmonary valve would introduce a ‘living’ valvular construct that should grow with the patient. Our study is particularly important for pediatric patients who often require repeated operations for pulmonary valve replacements,” said lead author David L. Simpson, PhD, from the University of Maryland School of Medicine in Baltimore.
Dr. Simpson, senior co-author Sunjay Kaushal, MD, PhD, and colleagues designed a process to transform skin cells from a simple biopsy into cells that become an important ingredient in a tissue-engineered pulmonary valve.
The pulmonary valve is a crescent-shaped valve that lies between the heart’s right ventricle and pulmonary artery. It is responsible for moving blood from the heart into the lungs.
While the study was conducted in vitro (outside of the body), the next step will be implanting the new valves into patients to test their durability and longevity.
The Latest on: Reprogramming skin cells
via Google News
The Latest on: Reprogramming skin cells
- 3D printing aids stem cell research into equine fractureson June 25, 2019 at 1:24 pm
iPS cells are created by ‘reprogramming’ an adult cell, such as a skin cell, to turn back into a stem cell state where they can grow forever in the lab and turn into any cell type of the body. “They ... […]
- New method allows cells to be produced in shorter time and with greater successon June 13, 2019 at 11:38 pm
... existing cells of the body (such as skin cells), they are referred to as induced pluripotent stem cells, or iPS in short. While transformative and hugely important, Yamanaka's reprogramming method ... […]
- The genetics of parthenogenesison May 9, 2019 at 7:02 am
potentially leading to the creation of a human embryo without the need for sperm or egg cells. The reprogramming ability of skin cells was first demonstrated in 2006 with the introduction of the ... […]
- UW–Madison research team finds new ways to generate stem cells more efficientlyon May 7, 2019 at 12:45 pm
and improved understanding of how cells become reprogrammed from one cell type to another, for instance, transforming a skin cell to a cardiac cell. And it includes some surprises, the authors say. ... […]
- Creating human embryos out of human skin cellson May 5, 2019 at 4:51 am
Back in 2006, Japanese researchers discovered the capacity of skin cells to be "reprogrammed" into early embryonic cells that can generate an entire foetus, by expressing four central embryonic genes. ... […]
- Researchers create embryo stem cells from skin cells: Here's all you need to knowon May 5, 2019 at 12:31 am
The HU team used new technology to scrutinise the molecular forces that govern cell fate decisions for skin cell reprogramming and the natural process of embryonic development. Researchers have found ... […]
- Scientists Create Embryo Stem Cells from Skin Cellson May 4, 2019 at 1:04 pm
‘A new combination of five genes that, when inserted into skin cells, reprogram the cells into each of three early embryonic cell types--iPS cells which create fetuses, placental stem cells, and stem ... […]
- Embryo stem cells created from skin cellson May 2, 2019 at 2:05 pm
Back in 2006, Japanese researchers discovered the capacity of skin cells to be "reprogrammed" into early embryonic cells that can generate an entire fetus, by expressing four central embryonic genes. ... […]
- Hebrew University researchers create embryo stem cells from skin cellson May 2, 2019 at 4:21 am
In 2006, Japanese researchers Kazutoshi Takahashi and Shinya Yamanaka discovered the capacity of skin cells to be “reprogrammed” into early embryonic cells that can generate an entire fetus through ... […]
- Hebrew U Researchers Created Embryo Stem Cells from Skin Cellson May 2, 2019 at 4:00 am
Back in 2006, Japanese researchers discovered the capacity of skin cells to be “reprogrammed” into early embryonic cells that can generate an entire fetus, by expressing four central embryonic genes. ... […]
via Bing News