Scientists at the Salk Institute have discovered an on-and-off “switch” in cells that may hold the key to healthy aging. The switch controls the growth of telomeres, the timekeepers of cells
This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age.
In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. However, most human cells cannot divide indefinitely–with each division, a cellular timekeeper at the ends of chromosomes shortens. When this timekeeper, called a telomere, becomes too short, cells can no longer divide, causing organs and tissues to degenerate, as often happens in old age. But there is a way around this countdown: some cells produce an enzyme called telomerase, which rebuilds telomeres and allows cells to divide indefinitely.
In a new study published September 19th in the journal Genes and Development, scientists at the Salk Institute have discovered that telomerase, even when present, can be turned off.
“Previous studies had suggested that once assembled, telomerase is available whenever it is needed,” says senior author Vicki Lundblad, professor and holder of Salk’s Ralph S. and Becky O’Connor Chair. “We were surprised to discover instead that telomerase has what is in essence an ‘off’ switch, whereby it disassembles.”
Understanding how this “off” switch can be manipulated–thereby slowing down the telomere shortening process–could lead to treatments for diseases of aging (for example, regenerating vital organs later in life).
The Latest on: Telomerase
via Google News
The Latest on: Telomerase
- Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cellson July 22, 2019 at 2:20 am
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and ... […]
- Dr. Michael Fossel: Compassion is the reason to reverse aging!on July 14, 2019 at 10:11 pm
An excellent interview. Fossel and Aubrey de Grey of the SENS Foundation are in disagreement about telomerase. https://www.singularityweblog.com/michael-fossel/ Michael Fossel‘s dream is to reverse ... […]
- Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell deathon July 11, 2019 at 3:18 am
G-quadruplex telomeric secondary structures represent natural replication fork barriers and must be resolved to permit efficient replication. Stabilization of telomeric G4 leads to telomere ... […]
- PES1 is a critical component of telomerase assembly and regulates cellular senescenceon May 15, 2019 at 11:58 am
1 Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China. 2 Department of Biochemistry and Molecular ... […]
- Newly-discovered on/off switch could hold the key to healthy agingon September 22, 2018 at 5:00 pm
Researchers at the Salk Institute have discovered an on/off switch for telomerase, an enzyme that rebuilds a cellular timekeeper known as a telomere. The scientists believe that the discovery could ... […]
- Gene therapy vectors carrying the telomerase gene do not increase the risk of canceron August 20, 2018 at 7:35 am
Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway ... […]
- 【Success Entertainment Group International, Inc. Announces Investment into Taiwan EverLive Telomerase Limited (TETL)】on August 14, 2018 at 6:54 am
TAIPEI, Taiwan, Aug. 14, 2018 (GLOBE NEWSWIRE) -- Mr. Steve Chen, Chairman of the Board of Directors of Success Entertainment Group International Inc. (OTCQB: SEGN) has stated that in recent years, ... […]
- Scientists see inner workings of enzyme telomerase, which plays key roles in aging, canceron June 6, 2018 at 9:54 am
Cancer, aging-related diseases and other illnesses are closely tied to an important enzyme called “telomerase.” UCLA researchers report in the journal Cell the deepest scientific understanding yet of ... […]
- Making The Bull Case For Geron: Understanding The Risk/Reward Of Telomerase Biologyon May 18, 2018 at 1:45 am
A fateful decision by Johnson & Johnson informing Geron as to whether development of Imetelstat proceeds, will be made by the end of the third quarter. A better understanding of telomerase biology ... […]
- Long-sought structure of telomerase paves way for drugs for aging, canceron April 25, 2018 at 10:01 am
More than 30 years ago, when UC Berkeley researchers discovered telomerase — an enzyme that lengthens chromosome ends and prevents them from fraying enough to kill a cell — speculation ran wild about ... […]
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