Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them — and for leading to a dire prognosis for patients.
But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The method, reported in the journal ACS Nano, could someday vastly improve the outlook for patients.
Moritz F. Kircher and colleagues at Memorial Sloan Kettering Cancer Center point out that malignant brain tumors, particularly the kind known as glioblastoma multiforme (GBM), are among the toughest to beat. Although relatively rare, GBM is highly aggressive, and its cells multiply rapidly. Surgical removal is one of the main weapons doctors have to treat brain tumors. The problem is that currently, there’s no way to know if they have taken out all of the cancerous cells. And removing extra material “just in case” isn’t a good option in the brain, which controls so many critical processes. The techniques surgeons have at their disposal today are not accurate enough to identify all the cells that need to be excised. So Kircher’s team decided to develop a new method to fill that gap.
The researchers used a handheld device resembling a laser pointer that can detect “Raman nanoprobes” with very high accuracy. These nanoprobes are injected the day prior to the operation and go specifically to tumor cells, and not to normal brain cells. Using a handheld Raman scanner in a mouse model that mimics human GBM, the researchers successfully identified and removed all malignant cells in the rodents’ brains. Also, because the technique involves steps that have already made it to human testing for other purposes, the researchers conclude that it has the potential to move readily into clinical trials. Surgeons might be able to use the device in the future to treat other types of brain cancer, they say.
The Latest on: Brain tumor removal
via Google News
The Latest on: Brain tumor removal
- Pine County Deputy Benjamin Neel Dies Following Stroke Suffered In Brain Surgeryon January 10, 2020 at 9:08 am
Doctors later found two tumors in his brain. One tumor was removed in early December, but Neel suffered a massive brain stem stroke due to complications in surgery. He was unable to recover. Neel was ...
- New function for potential tumor suppressor in brain developmenton January 10, 2020 at 7:35 am
When Cdkn1c is removed only in certain cells of the brain, these cells die, arguing for a new growth promoting role of Cdkn1c. The new research is published today in the journal Nature Communications.
- Surgical Removal of Tumor may Improve Survival in Deadly Brain Cancerson January 10, 2020 at 12:53 am
‘For adult patients with rare and deadly brain cancer, surgically removing the entire tumor may add more months ... Consequently, a growing number of patients have opted for partial or total removal ...
- New technology in St. George allows for real-time imaging during brain surgeryon January 9, 2020 at 8:27 pm
Keith Barney said the doctor told him the tumor could become cancerous if it wasn’t taken care of when they removed it. “I was a few months away from having brain cancer,” he said. After surgery, ...
- AI matches human brain cancer diagnosis: studyon January 9, 2020 at 1:58 pm
In a clinical trial of 278 brain tumour patients, the authors found that the ... said the findings could help surgeons and patients when it comes to surgical cancer removal. "Plainly stated, this ...
- Total tumor removal may extend survival for patients with deadly gliomaon January 9, 2020 at 9:52 am
The researchers point out that survival for these gliomas—one of the rarest and deadliest forms of brain cancer—has remained poor, with a median length of eight months after diagnosis in people who ...
- Tumor Tissue Imaging and AI Bypass Path Lab for Brain Surgerieson January 9, 2020 at 8:01 am
... of Michigan have shown that it’s possible to accurately analyze brain tumor tissue within the operating room and assess its nature using artificial intelligence. Tumor tissues typically look just ...
- Surgery may add months or years of survival for adults with rare and deadly brain cancerson January 9, 2020 at 6:55 am
For adult patients with brainstem high-grade gliomas—one of the rarest and deadliest forms of brain cancer—surgically removing the ... zones," making surgery possible for previously inoperable tumors.
- Surgical removal of tumor may boost survival of patients with brainstem high-grade gliomason January 9, 2020 at 6:15 am
For adult patients with brainstem high-grade gliomas -- one of the rarest and deadliest forms of brain cancer -- surgically removing the ... zones," making surgery possible for previously inoperable ...
- AI matches humans at diagnosing brain cancer from tumour biopsy imageson January 8, 2020 at 3:45 am
Particularly aggressive tumours can be removed entirely, but this rarely works for brain cancer because the tumours are often integrated into the brain itself. Hollon’s team then put the AI to the ...
via Bing News