A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
Scientists are not just excited about this recently discovered technique because it can snip and edit DNA with precision. It can also do the job more easily and cheaply than other gene-editing methods, making possible research that has historically been difficult, experts say.
Now some of the biologists who unlocked this tool, derived from the immune system of bacteria, are forming companies around it. Although this molecular system, known as Crispr, is not fully understood, researchers believe it can be harnessed to create therapies for intractable genetic diseases.
“In principle, this is a technology that could enable correction of genetic mutations that would otherwise lead to disease,” said Doudna, a professor of chemistry and biochemistry and molecular biology, in a telephone interview. She was among several experts who spoke at a UC Berkeley conference on the subject last month.
But because the method is in its infancy and has little precedent with the agencies that regulate medicines, it will almost certainly be a long time before a Crispr-based therapy makes it to market.
Its potential risks also concern some bioethicists.
The Latest on: Editing DNA
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The Latest on: Editing DNA
- The Europe genome editing market is expected to reach US$ 3,421.1 Mn in 2025 from US$ 1,052.9 Mn in 2017on January 24, 2020 at 10:06 pm
New York, Jan. 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Europe Genome Editing Market to 2025 - Regional Analysis and Forecasts ...
- DNA sleuths read the coronavirus genome, tracing its origins and looking for dangerous mutationson January 24, 2020 at 4:28 pm
Reading the DNA also allows researchers to monitor how 2019-nCoV is changing ... said biologist Richard Ebright of Rutgers University. For instance, the genome-editing technology CRISPR is the basis ...
- Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editingon January 24, 2020 at 5:00 am
Enhancers are cis-regulatory DNA sequences that are bound and regulated by transcription factors (TFs ... Additionally, conventional gene targeting or genome editing approaches have been utilized to ...
- Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in miceon January 24, 2020 at 4:58 am
Recently, extremely small homology arms of ~20 bps (microhomology arms), relative to the conventional homology arms sized a few hundred bps or more, have been successfully applied to edit mammalian ...
- Algentech Granted US Patent For A Key Genome Editing Technologyon January 21, 2020 at 8:54 am
/PRNewswire/ -- ALGENTECH, announces the issuance of a key patent in the field of genome editing by the U.S. Patent Office (U.S. patent number 10457950).
- Birmingham company spotlights work in gene editing fieldon January 20, 2020 at 8:00 am
The company’s work being spotlighted at the conference impacts CRISPR-CAS systems. CRISPR, which stands for clustered regularly interspaced short palindromic repeats, is the name for gene editing - ...
- Kill-Switch for CRISPR Could Make Gene-Editing Saferon January 17, 2020 at 7:04 am
The darling of genome editing has been the type II system and its archetypal DNA-cutting protein, Cas9. “For the wider biological audience to really take notice,” says Pawluk, now an editor at Cell, ...
- Muscular Dystrophy Collaboration Aims to Correct Muscle Stem Cells’ DNAon January 17, 2020 at 12:53 am
Harvard stem cell research receives support from Sarepta to advance in-vivo genome editing toward prospective therapy for Duchenne muscular dystrophy ...
- Opening up DNA to delete diseaseon January 15, 2020 at 2:48 pm
When examining the chromatin-packed state, the team found several editorial assistants, which are called DNA-binding transiently expressed activation-associated proteins (AAPs), disrupted the ...
- Human gene editing: who decides the rules?on January 15, 2020 at 6:07 am
Gene editing in humans takes one of two forms. In somatic gene editing, changes are made to DNA in a person’s body cells. In germline editing, changes are made to the DNA in embryos, sperm or ...
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