A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
Scientists are not just excited about this recently discovered technique because it can snip and edit DNA with precision. It can also do the job more easily and cheaply than other gene-editing methods, making possible research that has historically been difficult, experts say.
Now some of the biologists who unlocked this tool, derived from the immune system of bacteria, are forming companies around it. Although this molecular system, known as Crispr, is not fully understood, researchers believe it can be harnessed to create therapies for intractable genetic diseases.
“In principle, this is a technology that could enable correction of genetic mutations that would otherwise lead to disease,” said Doudna, a professor of chemistry and biochemistry and molecular biology, in a telephone interview. She was among several experts who spoke at a UC Berkeley conference on the subject last month.
But because the method is in its infancy and has little precedent with the agencies that regulate medicines, it will almost certainly be a long time before a Crispr-based therapy makes it to market.
Its potential risks also concern some bioethicists.
The Latest on: Editing DNA
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The Latest on: Editing DNA
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- Beam Therapeutics Presents Preclinical Data for Complementary Base Editing Approaches for Hemoglobinopathies at ASH 2019on December 8, 2019 at 4:00 am
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- New tool can rapidly reveal unintended changes made by CRISPR-directed gene editingon December 6, 2019 at 12:03 pm
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- Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repairon December 6, 2019 at 10:36 am
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- New Tool for Rapidly Analyzing CRISPR Edits Reveals Frequent Unintended DNA Changeson December 6, 2019 at 5:15 am
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- Genome Editing/Genome Engineering Market is anticipated to grow at a 14.1% CAGR from 2019 to 2030on December 6, 2019 at 4:37 am
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- Kafer: Hope for Colorado kids hangs on gene editingon December 5, 2019 at 2:41 pm
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- Advances in genome editing through control of DNA repair pathwayson December 2, 2019 at 9:52 am
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage. Advancements in genome editing take advantage of these pathways to produce permanent genetic changes. Despite recent ...
- CRISPR Vehicles Break Down Barriers to In Vivo Genome Editingon December 2, 2019 at 4:39 am
These two elements suffice if the goal is to use CRISPR to introduce a targeted deletion in the genome, via a DNA repair mechanism known as nonhomologous end joining (NHEJ). For example, the therapy ...
- Genomics ETFs Surge on CRISPR's Gene Editing Progresson November 26, 2019 at 7:51 am
On the brighter side, the complications were found to be unrelated to the gene-editing treatment. Genomic ETFs in Focus Genome editing is a technique to alter or modify the DNA of a cell or organism.
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