A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
Scientists are not just excited about this recently discovered technique because it can snip and edit DNA with precision. It can also do the job more easily and cheaply than other gene-editing methods, making possible research that has historically been difficult, experts say.
Now some of the biologists who unlocked this tool, derived from the immune system of bacteria, are forming companies around it. Although this molecular system, known as Crispr, is not fully understood, researchers believe it can be harnessed to create therapies for intractable genetic diseases.
“In principle, this is a technology that could enable correction of genetic mutations that would otherwise lead to disease,” said Doudna, a professor of chemistry and biochemistry and molecular biology, in a telephone interview. She was among several experts who spoke at a UC Berkeley conference on the subject last month.
But because the method is in its infancy and has little precedent with the agencies that regulate medicines, it will almost certainly be a long time before a Crispr-based therapy makes it to market.
Its potential risks also concern some bioethicists.
The Latest on: Editing DNA
via Google News
The Latest on: Editing DNA
- In its first tough test, CRISPR base editing slashes cholesterol levels in monkeyson June 27, 2020 at 2:56 pm
When CRISPR “base editing” knocked out two cholesterol-associated genes in monkeys, the animals’ blood levels of LDL cholesterol and triglycerides plunged.
- Verve Therapeutics Presents New Data in Non-Human Primates Validating Gene Editing as a Treatment Approach for Coronary Heart Disease at the ISSCR 2020 Virtual Annual Meetingon June 27, 2020 at 2:45 pm
Verve Therapeutics, a next-generation cardiovascular company, today announced the presentation of new preclinical proof-of-concept data in non-human p ...
- Catholic bioethicist warns against gene-editing experimentson June 27, 2020 at 11:28 am
In the wake of a gene-editing experiment gone wrong, the president of the National Catholic Bioethics Center said that the Church must stand firm against the unborn being “sacrificed on the altar of ...
- Parkinson’s gene editing breakthrough in mice offers hope for patients – their damaged neurons could be replacedon June 26, 2020 at 3:07 pm
A team of US- and China-based researchers used genome editing to convert a different type of brain cell ... the molecule that codes DNA. “When you deplete this protein, practically any cell we tested ...
- CRISPR Gene Editing in Human Embryos Wreaks Chromosome Mayhemon June 25, 2020 at 12:03 pm
Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing ...
- CRISPR gene editing in human embryos wreaks chromosomal mayhemon June 25, 2020 at 7:48 am
Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.
- Gene Editing Market on Target to Reach $9.2 Billion 2026on June 24, 2020 at 12:42 am
The global gene editing market is expected to grow at a CAGR of 15.3% from 2020 to 2026 and expected to reach around US$ 9.2 Bn by 2026 ...
- Light-activated 'CRISPR' enables fast, precise gene editing and detection of DNA repairon June 23, 2020 at 1:05 pm
In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger to make quick, precise cuts in the genomic material of human cancer ...
- Light-activated 'CRISPR' triggers precision gene editing and super-fast DNA repairon June 17, 2020 at 9:45 am
In a series of experiments using human cancer cell lines, scientists say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel ...
- Precision genome editing enters the modern eraon June 15, 2020 at 5:26 am
CRISPR has sparked a renaissance in genome editing. Now, next-generation CRISPR technologies let scientists modify the genome more efficiently and precisely than before. Such tools could one day serve ...
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