A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
Scientists are not just excited about this recently discovered technique because it can snip and edit DNA with precision. It can also do the job more easily and cheaply than other gene-editing methods, making possible research that has historically been difficult, experts say.
Now some of the biologists who unlocked this tool, derived from the immune system of bacteria, are forming companies around it. Although this molecular system, known as Crispr, is not fully understood, researchers believe it can be harnessed to create therapies for intractable genetic diseases.
“In principle, this is a technology that could enable correction of genetic mutations that would otherwise lead to disease,” said Doudna, a professor of chemistry and biochemistry and molecular biology, in a telephone interview. She was among several experts who spoke at a UC Berkeley conference on the subject last month.
But because the method is in its infancy and has little precedent with the agencies that regulate medicines, it will almost certainly be a long time before a Crispr-based therapy makes it to market.
Its potential risks also concern some bioethicists.
The Latest on: Editing DNA
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The Latest on: Editing DNA
- Taking the sting out: Australian gene editing is crossing the pain thresholdon July 20, 2019 at 2:00 pm
It was a simple but groundbreaking technique, using the latest in genetics technology – Crispr, the gene-editing tool that allows scientists to make precise changes to DNA. The process is fascinating ... […]
- Researchers create new type of gene-editing technology to fight diseaseson July 20, 2019 at 5:36 am
LEAPER, which stands for ‘leveraging endogenous ADAR for programmable editing of RNA’, works in a similar fashion to the CRISPR-Cas13 that targets RNA molecules as opposed to the DNA ones like it’s ... […]
- CRISPR-Cas9 Gene Editing Technologies Market is projected to witness significant growth in the next few yearson July 18, 2019 at 11:56 pm
Click here to find out insight CRISPR-Cas9 Gene Editing Technologies trends @ https ... Inc. (U.S.), Integrated DNA Technologies, Inc. (U.S.), Lonza (Switzerland), New England Biolabs (U.S.), CRISPR ... […]
- Researchers develop a more precise version of CRISPR-Cas9 gene-editing systemon July 18, 2019 at 6:58 am
The classic CRISPR-Cas9 gene editing works with gRNA as guiding molecule. gRNA recognizes the mutation in the target DNA and guides Cas9 to snip it. "Unfortunately this guide RNA is not entirely ... […]
- Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADARon July 18, 2019 at 2:22 am
Variants in the human double-stranded RNA editing enzyme ADAR produce three well-characterized rare Mendelian Diseases: Dyschromatosis Symmetrica Hereditaria (OMIM: 127400), Aicardi-Goutières syndrome ... […]
- Following ‘CRISPR babies’ scandal, senators call for international gene editing guidelineson July 15, 2019 at 3:22 pm
Marco Rubio (R-Fla.), and Jack Reed (D-R.I.) also reiterated support for international groups working to produce guidelines for the clinical use of germline editing — meaning changes to the DNA in ... […]
- CRISPR Tool Doubles Number of Pathogenic Mutations Targetable by RNA Editingon July 12, 2019 at 3:15 pm
[Stephen Dixon] CRISPR-based gene editing tools have revolutionized how scientists can target gene mutations and manipulate gene expression. Such tools hinge on the use of the enzymes Cas9 and Cas12 ... […]
- Scientists successfully edit a long-locked part of plant DNA, improving crop securityon July 9, 2019 at 1:35 am
Think of DNA and chances are the double helix structure comes to mind, but that's only one piece of the puzzle. Another major part is mitochondrial DNA, and in plants that's even more important ... […]
- Researchers capture high-resolution, 3D images of gene-editing enzymeson July 9, 2019 at 12:54 am
"It is exciting to be able to see at such a high level of detail how Cas9 actually works to cut and edit DNA strands," said UBC researcher Sriram Subramaniam, who led the cryo-EM studies. "These ... […]
- Gene-editing enzymes imaged in 3Don July 8, 2019 at 1:03 pm
"It is exciting to be able to see at such a high level of detail how Cas9 actually works to cut and edit DNA strands," lead study author Sriram Subramaniam, researcher at the University of British ... […]
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