Prototype’s novel approach uses magnetic nano-sized beads to filter deadly microbes and toxins from the bloodstream
Sepsis—a life-threatening over-reaction by the immune system to infection—afflicts 18 million people a year worldwide and kills between 30 and 50 percent of them. Sepsis poses a significant threat to warfighters who suffer combat injuries that predispose them to infection. Antibiotics can kill sepsis-inducing microbes but their overuse is contributing to the threat of drug-resistant microbes and they don’t neutralize the toxins that some pathogens leave behind. Commercial dialysis equipment can remove toxins from the blood but is not built for routine use in theater.
DARPA’s Dialysis-Like Therapeutics (DLT) program seeks to develop integrated, portable and ruggedized technology that would enable widespread deployment of dialysis treatment to fight sepsis. The program recently tested a novel prototype that could greatly advance sepsis treatment and lead to increased survival of future sepsis patients. As reported in Nature Medicine (http://ow.ly/BvJOm), the DLT program successfully demonstrated one of the first technologies for pathogen removal via blood filtration. With a design inspired by the human spleen, the shoebox-sized prototype removes many of the microbes and toxins that can trigger sepsis.
“Sepsis is a massive problem for both civilian and military healthcare, which is why DARPA set out to develop more effective and portable technologies for sepsis treatment,” said U.S.Army Col. Matt Hepburn, DARPA program manager. “Our ‘artificial spleen’ prototype shows a promising new way to fight sepsis more quickly and thoroughly. The technology is also small and light, and usable either on its own or with commercial dialysis equipment.”
Eventually, Hepburn added, DLT could preclude the need to fully identify a bacterium or test whether it is antibiotic resistant—which can take hours or days—before beginning treatment. “We’re hopeful that this new technology could give doctors new tools to save lives in the future,” he said.
The Latest on: Artificial spleen
via Google News
The Latest on: Artificial spleen
- A novel selection strategy for antibody producing hybridoma cells based on a new transgenic fusion cell lineon February 3, 2020 at 2:24 am
The cell line carries an artificial cell surface marker for isotype- and antigen-specific binding of ... Fusion and HAT selection of HA-AP-EGF-R-containing Sp2/0 cells with spleen lymphocytes from ...
- Scientists Mix Pig And Human Genes To Create Hybrid Skin To Help Burn Survivorson January 30, 2020 at 5:54 am
The artificial skin was first tested on macaque monkeys and it ... they were found to have monkey DNA in their heart, liver, spleen, lung, and skin. The two chimera pigs were born from 4,000 embryos ...
- An Overview of Red Blood Cell Lysison January 30, 2020 at 3:11 am
Other causes of hemolysis include artificial heart values, heart-lung bypass machines ... Usually, red blood cells live for around 120 days, and when they die, the spleen removes them from the blood.
- God of Carnage review, Theatre Royal Bath: an entertaining but un-threatening middle-class fracason January 21, 2020 at 3:00 pm
of artificial civility. In isolation, the performances have much to commend them, even though they don’t satisfactorily gel. As the ostensibly conciliatory hostess (and mother of the thwacked boy), ...
- New auto-inflammatory disease called CRIA syndromeon January 7, 2020 at 4:00 pm
Symptoms include fevers, swollen lymph nodes, severe abdominal pain, gastrointestinal problems, headaches and, in some cases, abnormally enlarged spleen and liver. The disorder has characteristics ...
- ELeCt-ing a better candidate for chemo deliveryon November 13, 2019 at 11:07 am
largely because they are quickly cleared from the blood by the liver and spleen. Now, a new technique called ELeCt (erythrocyte-leveraged chemotherapy) developed at Harvard's Wyss Institute for ...
- Simon Tranon May 17, 2019 at 3:58 pm
Cell extracts from spleen and adipose tissues restore function to irradiation ... Re-engineering Primary Epithelial Cells from Rhesus Monkey Parotid Glands for Use in Developing an Artificial Salivary ...
- How do I ease gastric pain and bloatedness?on February 10, 2019 at 3:32 am
The spleen transforms nutrients from food into ... Similarly, watch out for fructose and artificial sugar (normal table sugar does not cause gas) in sweetened drinks. Not all spices are bad.
- Savor the Tastes of Local Culture in Retirementon December 4, 2018 at 6:59 am
The couple also watched local farmers turn goat milk into ricotta cheese, sampled sandwiches made from cow spleen and lungs ... which are artificial ponds where salt is collected.
- Artificial Spleen Sorts Things Outon October 14, 2014 at 5:00 pm
Sepsis is a lethal disease caused by systemic microbial infection spreading through the bloodstream to overwhelm the body's defenses. Identifying the responsible pathogen can take days—in fact, in ...
via Bing News