Trapping liquid chemicals in crystals form may lead to better, safer and cheaper medicines and more environmentally-friendly chemicals for the farm
A new approach for formulating the active chemical ingredients of common drugs and agricultural products has been developed by researchers in Italy, and it holds broad potential to make such products more durable, safer, cheaper, easier to manufacture and less harmful to the environment.
The technique involves taking the active chemical ingredients found in human drugs and agrochemicals, many of which are liquids, and stabilizing them with other molecules into “co-crystals,” essentially rendering them solid. Co-crystals are materials composed of two or more molecules in the same crystal lattice — conceptually you can picture a checkerboard stacked up and down and right to left with black and red pieces together.
While the idea is still in its infancy, a presentation at the 23rd Congress and General Assembly of the International Union of Crystallography, next week in Montreal will describe the first initial results of this approach, which were successful.
“The work is promising because we successfully combined into crystals a set of liquid pharmaceutical and agrochemical molecules with carefully chosen molecular partners, and thus we were able to obtain solid forms containing the liquid active molecules embedded in the ordered solid,” said Alessia Bacchi, a professor at the University of Parma in Italy who led the research.
As a general approach, co-crystallization should be able to stabilize many types of liquid chemicals into solid form, Bacchi said. Reformulating pharmaceuticals in this way could give some drugs a longer shelf life, eliminate the need for refrigeration for others, simplify some manufacturing processes, possibly reduce costs and provide patients with a pill form of a drug they could take easier than a liquid.
The Latest on: Co-Crystals
via Google News
The Latest on: Co-Crystals
- New kind of alien 'mineral' created on Earthon December 6, 2019 at 12:55 pm
There, they condensed and eventually rearranged into the newfound co-crystals. The team was also curious how stable the odd substance would be at Titan’s surface temperatures and pressures.
- Guidances and Manuals on Pharmaceutical Qualityon May 30, 2019 at 5:00 pm
This page provides quick access to guidances documents for industry on pharmaceutical quality topics, including drug application/license policies on quality. In addition to the guidance document ...
- US FDA’s co-crystal final guidance to reduce cGMP burdenon February 15, 2018 at 4:13 am
In response to stakeholder feedback, the US FDA has issued a final guidance detailing changes to the regulatory classification of co-crystals, from intermediate to API. The US Food and Drug ...
- FDA Publishes Guidance on Classification of Co-Crystalson February 13, 2018 at 4:00 pm
regarding the regulatory classification of co-crystal solid-state forms not previously evaluated by the agency and determined to be pharmaceutical co-crystals. The guidance also discusses which data ...
- Regulatory Classification of Pharmaceutical Co-Crystals- Drafton January 12, 2018 at 1:24 am
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. The https:// ensures that you are ...
- US FDA issues norms for classification of pharmaceutical co-crystals, seeks industry views by October-endon August 23, 2016 at 12:59 am
US FDA has issued regulatory classification of pharmaceutical co-crystals guidance for industry. The industry is expected to revert with its comments by October end. The guidance provides applicants ...
- FDA to Reclassify Pharmaceutical Co-Crystalson August 16, 2016 at 11:15 am
As part of an effort to clarify and help advance the development of pharmaceutical co-crystals, the US Food and Drug Administration (FDA) on Tuesday released revised draft guidance providing ...
- US FDA issues norms on Regulatory Classification of Pharmaceutical Co-Crystalson May 15, 2013 at 12:59 am
US Food and Drug Administration (FDA) has now issued guidance on Regulatory Classification of Pharmaceutical Co-Crystals. It provides applicants of new drug applications (NDAs) and abbreviated new ...
- FDA guidance on API-excipient co-crystals unnecessary; Amgenon March 5, 2012 at 3:07 am
Amgen has called FDA draft guidance on API-excipient co-crystals unnecessary in its written response to the Agency. The comments follow draft co-crystal guidance from the US Food and Drug ...
- Co-crystals give light a tune-upon January 23, 2012 at 4:00 pm
Stacking of a chromophoric molecule in the solid state has been altered rationally by the formation of co-crystals, allowing fine control of luminescence. Download PDF The properties of individual ...
via Bing News