‘Halo-like’ device fits on head to quickly bust clots
A new device developed by a physician at the University of Arkansas for Medical Sciences and a researcher at the University of Arkansas at Little Rock could soon be available to treat stroke more effectively.
The ClotBust ER® fits on the head like a halo and delivers therapy to quickly bust clots that cause stroke.
It was developed by William Culp, M.D., professor of radiology, surgery and neurology and vice chairman of research at UAMS, and Doug Wilson, assistant director at the Graduate Institute of Technology at UALR.
Culp has spent many years studying therapy for stroke. One element of Culp’s work included using ultrasound in combination with the clot-busting drug tissue plasminogen activator (t-PA).
While looking into the treatment to dissolve clots in blood vessels, Culp realized one problem is getting the ultrasound to operate through the skull. Ultrasound can be delivered anywhere in a patient’s body unless the waves hit something hard like bone or something very soft, like air.
“We realized we had trouble delivering ultrasound to the vessels at the base of the brain,” Culp said. “The skull stopped the ultrasounds.”
He teamed with Wilson to brainstorm ideas about how to get the ultrasound waves to reach the clot in stroke patients.
“This is a great example of how faculty at both schools can partner to develop new technologies. The success of this research will foster ties between the two campuses,” Wilson said.
“It makes me extremely proud to have contributed to a product with potential to help many people,” he said.
Culp received an $8,000 grant from UAMS that provided him with the materials he needed to experiment. Wilson and Culp completed their first patent for “ultrasound for augmented clot lysis” in 2005. The patent was licensed in 2006 and has been in development by Cerevast Therapeutics.
The ClotBust ER® has 16 transducers scattered around the inside – designed to line up with the thin points in the skull: the temples and the foramen magnum in the base of the skull.
This allows the ultrasound waves to move through the brain without interruption. After the patient is administered an IV containing t-PA, the circular device is placed onto the patient’s head like a sports visor or halo.
“The idea is to deliver ultrasound wherever the clot is and where the IV t-PA is working,” Culp said. “It makes t-PA work better – improving the clot-busting drug by 40 or 50 percent. It’s like taking a cooking pot and stirring it. The ultrasound stirs the drug around, making it work better.”
The clot disappears more quickly. “If we resupply blood, we resupply oxygen. The brain recovers quicker. Quicker is, of course, better,” Culp said.
The Latest on: Stroke treatment
via Google News
The Latest on: Stroke treatment
- Case Study Indicates Link Between Stroke and Migraineon November 29, 2019 at 1:42 pm
Following brain magnetic resonance imaging, a right fronto-parietal ischemic stroke was found. Furthermore ... are needed to obtain insight into the pathogenic mechanisms underlying MI and to ...
- JOGO Health to Launch 30 Digital Therapeutics Clinics in Malaysia to Treat Stroke, Pain and Incontinenceon November 28, 2019 at 4:40 am
Bridgewater, NJ, November 28, 2019 --(PR.com)-- JOGOHEALTH Inc., a New Jersey, USA-based, privately held digital therapeutics company focused on the development and commercialization of treatments for ...
- Philips announces WE-TRUST multicenter clinical trial to assess impact of ‘Direct to Angio Suite’ workflow on stroke patient outcomeson November 27, 2019 at 4:24 pm
It will begin in the first half of next year and is expected to be completed in 2022. Outcomes for stroke patients are closely tied to how quickly they receive treatment: every 30 minutes’ delay ...
- Cancer patients are at a higher risk of dying from heart disease and stroke, new study showson November 26, 2019 at 2:19 pm
Cancer patients are at higher risk of dying from heart disease and stroke than the general population ... Another reason could be the aggressive treatment that comes after a cancer diagnosis. The ...
- Kessler Foundation participates in new study to test innovative treatment for hand paralysison November 26, 2019 at 2:04 pm
Kessler Foundation is participating in a phase II multi-site study of an innovative treatment to improve hand function in stroke survivors. Olga Boukrina, PhD, research scientist in the Center for ...
- Kessler Foundation receives NIH sub-award to test new treatment for hand paralysison November 26, 2019 at 12:21 pm
East Hanover, NJ. November 26, 2019. Kessler Foundation is participating in a phase II multi-site study of an innovative treatment to improve hand function in stroke survivors. Olga Boukrina, PhD, ...
- Her 10-year-old son had a stroke, now here's what she wants parents to knowon November 26, 2019 at 6:30 am
Stroke is one of the top 10 causes of death in children ... said the takeaway for parents is to know their kids and to listen to their own guts to know when symptoms call for further or emergency ...
- Tips to be fit: Hidden stroke riskson November 25, 2019 at 9:21 pm
This risk increases if you are a female, smoke and take oral contraceptives. If you migraines with auras you should discuss your stroke risk with your doctor. Chiropractic adjustments are a common ...
- Complete guide to stroke symptoms and treatmentson November 25, 2019 at 5:41 am
A stroke can be termed as a brain attack that tends to occur when the blood supply to the part of your brain is hampered or reduced. This can lead to deprivation of oxygen and nutrients, and the death ...
- Stroke Management Market 2019 Driving Factors, Industry Growth, Key Vendors and Forecasts to 2025on November 22, 2019 at 5:48 am
Increasing number of baby boomers in countries such as China and India will further surge the adoption of stroke management devices for effective diagnosis and treatment, thereby, augmenting industry ...
via Bing News