In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days.
The discovery by Salk scientists, published today in the journal Nature, could lead to a new generation of safer, more effective diabetes drugs.
The team found that sustained treatment with the protein doesn’t merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn’t result in side effects common to most current diabetes treatments.
“Controlling glucose is a dominant problem in our society,” says Ronald M. Evans, director of Salk’s Gene Expression Laboratory and corresponding author of the paper. “And FGF1 offers a new method to control glucose in a powerful and unexpected way.”
The Latest on: FGF1
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The Latest on: FGF1
- Differences in Osteogenic and Apoptotic Genes Between Osteoporotic and Osteoarthritic Patientson November 9, 2020 at 4:00 pm
Only FGF1 and VEGFA, genes involved in cell cycle regulation, are overexpressed (3.3 and 3.0-fold, respectively). From the family of metalloproteases, only MMP8 was up-regulated, and it is ...
- Differences in Osteogenic and Apoptotic Genes Between Osteoporotic and Osteoarthritic Patientson November 6, 2020 at 4:00 pm
On the contrary, FGF1 and VEGFA are two of the three genes with an increased expression in the OP group. All these results taken together suggest that osteoblastic activity is decreased in ...
- IMSD Studentson August 10, 2020 at 8:39 pm
Victor Acevedo, Ph.D., showed that fibroblast growth factor receptor-1 (FGF1) plays a role in the initiation, progression and maintenance of prostate cancer and found a potential window to slow or ...
- Prostate Cancer - Ittmann Labon May 28, 2020 at 6:13 pm
Fibroblast growth factors, including FGF1 (acidic FGF), FGF2 (basic FGF), FGF6, and FGF8 are all expressed at increased levels in prostate cancer as paracrine and/or autocrine growth factors for the ...
- Susanne Ulbrichon February 4, 2017 at 9:35 pm
We examined FGF1, FGF2, FGFR1, FGFR2, and FGFR3 in cyclic and early pregnant heifers at Days 12, 15, and 18 after insemination (Day 0). Endometrial FGF1 mRNA transcript abundance in heifers varied ...
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