A modified anticancer drug can simultaneously target tumor sites and show whether or not it is working
Cancer drugs can be modified to specifically target tumor sites to help personalize cancer treatment. And while it is relatively easy to determine if the drugs have been delivered to the correct location, it is more difficult to monitor their therapeutic success. Now, a team led by Bin Liu from the A*A*STAR Institute of Materials Research and Engineering in Singapore, in collaboration with Ben Zhong Tang at Hong Kong University of Science and Technology, has developed an anticancer drug with an inbuilt mechanism that shows if it is working1.
Platinum-based drugs are effective against many cancers, killing cells by triggering cellular suicide, or apoptosis. These drugs can, however, have severe side effects. Nontoxic forms can be modified, as a type of prodrug, to convert to their toxic form only after entering the targeted tumor cells, so as not to harm noncancerous cells.
Liu and colleagues went one step further by modifying a platinum-based prodrug to not only target tumor cells effectively, but also show whether or not it was having the desired effect. According to Liu, this added feature could be crucial for improving cancer treatment.
“Early evaluation of a patient’s response to a specific cancer therapy is important in clinical applications because it can minimize the duration of ineffective courses,” explains Liu. “The effectiveness of cancer treatment is commonly evaluated using magnetic resonance imaging to measure the tumor size, but this is unsatisfactory as the change in size is not obvious at the early stages of therapy.”
In their new system, Liu and her team included an apoptosis sensor that is released when the prodrug converts to its toxic form inside the targeted tumor cells. The toxic form triggers cell apoptosis and activates an enzyme called caspase 3, which then cleaves the apoptosis sensor and causes it to fluoresce green. This provides a visual signal that the drug is killing the cells.
The Latest on: Anticancer drug
via Google News
The Latest on: Anticancer drug
- 'Drug for arthritis in dogs can fight cancer in people'on January 22, 2020 at 4:00 pm
The researchers systematically analysed thousands of already developed drug compounds and found nearly 50 that have previously unrecognised anti-cancer activity. The findings, which also revealed ...
- Doc says drugs for inflammation, diabetes can kill cancer cellson January 22, 2020 at 2:29 pm
researchers at the Broad Institute’s Drug Repurposing Hub discovered. “We thought we’d be lucky if we found even a single compound with anti-cancer properties, but we were surprised to find so many,” ...
- Anticancer Activity Discovered in Dozens of Existing Noncancer Drugson January 22, 2020 at 5:29 am
Using a molecular barcoding technology called PRISM (profiling relative inhibition simultaneously in mixtures) the researchers were able to screen thousands of existing drug compounds against ...
- Dozens of potential anti-cancer drugs netted in screening studyon January 21, 2020 at 12:14 pm
Some of the compounds might in due course be tested in clinical trials, while others could help jump-start new drug development. Scientists reported their findings in the new journal Nature Cancer, ...
- VR During Chemotherapy Can Reduce The Stress Of Breast Cancer Patientson January 21, 2020 at 2:25 am
New research suggested that virtual-reality experience alongside chemotherapy can alleviate side effects among breast cancer patients.
- Non-Oncology Drugs Surprisingly Capable Of Killing Cancer Cellson January 20, 2020 at 10:50 pm
The analysis found nearly 50 drugs with previously unrecognized anti-cancer activity. This totally unexpected find also revealed novel drug mechanisms and targets. The study also suggests this ...
- Study uncovers anticancer potential of many non-oncology drugson January 20, 2020 at 5:05 pm
The researchers systematically analyzed thousands of already developed drug compounds and found nearly 50 that have previously unrecognized anti-cancer activity. The surprising findings, which also ...
- Dozens of non-oncology drugs can kill cancer cellson January 20, 2020 at 11:01 am
Researchers tested approximately 4,518 drug compounds on 578 human cancer cell lines and found nearly 50 that have previously unrecognized anti-cancer activity. These drugs have been used to treat ...
- Old Drug, New Tricks: Existing Medicines Show Promise in Fighting Canceron January 20, 2020 at 9:18 am
Lead author Steven Corsello practices oncology at the Dana-Farber Cancer Institute and researches new cancer drug development at the Broad Institute of the Massachusetts Institute of Technology and ...
- Discovering the anticancer potential of non-oncology drugs by systematic viability profilingon January 19, 2020 at 4:00 pm
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries have been serendipitous. We sought to create a public resource containing the growth-inhibitory activity of ...
via Bing News