Scientists at Brigham and Women’s Hospital (BWH) have developed a scalable, next-generation platelet bioreactor to generate fully functional human platelets in vitro. The work is a major biomedical advancement that will help address blood transfusion needs worldwide.
The study is published July 21, 2014 in Blood.
“The ability to generate an alternative source of functional human platelets with virtually no disease transmission represents a paradigm shift in how we collect platelets that may allow us meet the growing need for blood transfusions,” said Jonathan Thon, PhD, Division of Hematology, BWH Department of Medicine, lead study author.
According to the researchers, more than 2.17 million platelet units from donors are transfused yearly in the United States to treat patients undergoing chemotherapy, organ transplantation and surgery, as well as for those needing blood transfusions following a major trauma. However, increasing demand; a limited five-day shelf-life; and risk of contamination, rejection and infection have made blood platelet shortages common.
“Bioreactor-derived platelets theoretically have several advantages over conventional, donor-derived platelets in terms of safety and resource utilization,” said William Savage, MD, PhD, medical director, Kraft Family Blood Donor Center at Dana Farber Cancer Institute/Brigham and Women’s Hospital, who did not contribute to the study. “A major factor that has limited our ability to compare bioreactor platelets to donor platelets is the inefficiency of growing platelets, a problem that slows progress of clinical research. This study addresses that gap, while contributing to our understanding of platelet biology at the same time.”
The Latest on: Platelet bioreactor
via Google News
The Latest on: Platelet bioreactor
- Exclusive: Platelet BioGenesis Eyes Entering the Clinic, Doubling Employment in 2019on March 28, 2019 at 9:43 am
... a grant to move forward with his idea and he began to attract leaders in platelet research and Platelet BioGenesis was born. The bioreactor the company developed mimics the body’s working and bone ... […]
- Blood drive: Improving the yields of platelet cell manufacturingon March 27, 2019 at 11:14 am
Controlling oxygenation, media conditions, and CD34 + cell seeding density in gas-permeable bioreactors improve megakaryocyte yields. Over half of all patients with myelodysplastic cancer exhibit ... […]
- The polar vortex exposed a major flaw in our volunteer blood supply systemon February 28, 2019 at 1:42 am
Several groups, including Platelet BioGenesis, the company I co-founded, are working to turn that concept into reality. My group is developing a bioreactor that can make platelets from human stem ... […]
- 3D engineered bone marrow-like material produces functioning human plateletson February 25, 2019 at 4:00 pm
In the study, researchers aimed to create an artificial bioreactor that mimics the microenvironment present in bone marrow, facilitating the artificial formation of platelets. The new bioreactor ... […]
- Scientists find new way to make human plateletson February 23, 2019 at 12:01 am
They're traditionally created in our bone marrow. But scientists are now using a machine called a platelet bioreactor — along with human stem cells — to create platelets outside the human body. (Via ... […]
- Platelets prefer to be shaken, not stirredon August 15, 2018 at 11:19 am
Turbulent-flow bioreactors enable clinical scale production of mature, functional platelets. One of the long-standing applications of cell therapy comes in the form of transfused blood products, such ... […]
- Turbulent French Press Bioreactor Makes Platelets from Stem Cellson July 25, 2018 at 1:39 pm
Researchers at Kyoto University have developed a technique to produce platelets from induced pluripotent stem cells (IPS cells). Platelets are formed when small fragments break off from large cells ... […]
- Irregular flow improves bioreactor platelet productionon July 13, 2018 at 2:26 pm
Japanese scientists at the Center for induced Pluripotent Stem (iPS) Research and Application (CiRA) at Kyoto University have shown for the first time that small levels of turbulence in blood promote ... […]
- Turbulence allows clinical-scale platelet production for transfusionson July 12, 2018 at 8:04 am
Exposure to turbulent energy in a bioreactor stimulated hiPSC-derived bone marrow cells called megakaryocytes to produce 100 billion platelets—blood cell fragments that help wounds heal and prevent ... […]
- Turbulence is good for the bloodon July 12, 2018 at 8:03 am
In a new study seen in Cell, scientists at CiRA show unexpectedly that small levels of turbulence in the blood promotes the generation of platelets, the cells responsible for wound healing. Using this ... […]
via Bing News