“MitoQ completely restored endothelial function in the old mice. They looked like young mice.”
An antioxidant that targets specific cell structures—mitochondria—may be able to reverse some of the negative effects of aging on arteries, reducing the risk of heart disease, according to a new study by the University of Colorado Boulder.
When the research team gave old mice—the equivalent of 70- to 80-year-old humans—water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.
The researchers believe that MitoQ affects the endothelium, a thin layer of cells that lines our blood vessels. One of the many functions of the endothelium is to help arteries dilate when necessary. As people age, the endothelium is less able to trigger dilation and this leads to a greater susceptibility to cardiovascular disease.
“One of the hallmarks of primary aging is endothelial dysfunction,” said Rachel Gioscia-Ryan, a doctoral student in CU-Boulder’s Department of Integrative Physiology and lead author of the new study. “MitoQ completely restored endothelial function in the old mice. They looked like young mice.”
The study, published in the Journal of Physiology, was funded by the National Institute on Aging, one of the 27 institutes and centers of the National Institutes of Health and a leader in the scientific effort to understand the nature of aging.
To trigger blood vessel dilation, the endothelium makes nitric oxide. As we age, the nitric oxide meant to cause dilation is increasingly destroyed by reactive oxygen species such as superoxide, which are produced by many components of our body’s own cells, including organelles called mitochondria.
In a double-whammy, superoxide also reacts directly with the enzyme that makes nitric oxide, reducing the amount of nitric oxide being produced to begin with. All of this means less blood vessel dilation.
Even in the young and healthy, mitochondria produce superoxide, which is necessary in low levels to maintain important cellular functions. Superoxide is kept in check by the body’s own antioxidants, which combine with superoxide to make it less reactive and prevent oxidative damage to cells.
“You have this kind of balance, but with aging there is this shift,” said Gioscia-Ryan, who works in Professor Douglas Seals’ Integrative Physiology of Aging Laboratory at CU-Boulder. “There become way more reactive oxygen species than your antioxidant defenses can handle.”
That phenomenon, known as oxidative stress, occurs when the cells of older adults begin to produce too much superoxide and other reactive oxygen species. Mitochondria are a major source of superoxide in aging cells. The increased superoxide not only interacts with nitric oxide and the endothelium, but can also attack the mitochondria themselves. The damaged mitochondria become increasingly dysfunctional, producing even more reactive oxygen species and creating an undesirable cycle.
Past studies have looked at whether taking antioxidant supplements long term could improve vascular function in patients with cardiovascular disease by restoring balance to the levels of superoxide, but they’ve largely shown that the strategy isn’t effective.
This new study differs because it uses an antioxidant that specifically targets mitochondria. Biochemists manufactured MitoQ by adding a molecule to ubiquinone (also known as coenzyme Q10), a naturally occurring antioxidant. The additional molecule makes the ubiquinone become concentrated in mitochondria.
“The question is, ‘Why aren’t we all just taking a bunch of vitamin C?” Gioscia-Ryan said. “Scientists think that, taken orally, antioxidants like vitamin C aren’t getting to the places where the reactive oxygen species are being made. MitoQ basically tracks right to the mitochondria.”
The findings of the study indicate that the strategy of specifically targeting the mitochondria may be effective for improving the function of arteries as we age. In addition to improving endothelial function, the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice.
The Latest on: MitoQ
via Google News
The Latest on: MitoQ
- K2 Cycle event signs up with major sponsor MitoQon September 17, 2019 at 9:50 pm
The Coromandel's K2 is the toughest one-day cycle challenge in the Southern Hemisphere, and it's getting an energy boost with a new major sponsor MitoQ, a Kiwi company selling healthy ageing and ...
- MitoQ and Allergan Partner to Provide Hero CoQ10 Antioxidant for New Lumivive® Skincareon May 14, 2019 at 5:00 pm
We will be supplying our advanced CoQ10 antioxidant (MitoQ) for use in the new LUMIVIVE® product line, marketed under the SkinMedica® brand. It will be the first time that MitoQ has agreed to ...
- Double Honors for MitoQ in 2018 Aesthetic Everything® Awards: MitoQ Wins "Top Medical Nutraceutical" and Caprice Arkell Voted "Top Executive"on October 8, 2018 at 5:28 am
ORANGE COUNTY, Calif., Oct. 8, 2018 /PRNewswire-iReach/ -- Caprice Arkell, head of US Sales and Education for MitoQ Limited, was voted a "Top Executive" in the Aesthetic Everything ® Awards.
- NZ anti-ageing drug in promising heart disease findingson April 24, 2018 at 5:00 pm
Mitoubiquinone mesylate, marketed as MitoQ, is a New Zealand owned and developed super-antioxidant that works by penetrating and optimising the cellular mitochondria, the so-called batteries ...
- Study: Antioxidant Protects Liver From Alcohol Damageon March 1, 2018 at 7:19 pm
The answer might well be yes. Researchers at the University of Alabama in Birmingham have developed an antioxidant they dubbed mitochondria-targeted ubiquinone, or MitoQ. When introduced to the livers ...
- MitoQ Antioxidant Makes Old Arteries Seem Young Again - Studyon May 4, 2014 at 5:00 pm
A research team gave old mice - the equivalent of 70- to 80-year-old humans - water containing an antioxidant known as MitoQ for four weeks and found that their arteries functioned as well as the ...
- MitoQ – An antioxidant that may cure multiple sclerosison December 28, 2013 at 10:00 am
Researchers led by an Indian-American scientist P. Hemachandra Reddy at the Oregon Health and Science University have discovered that MitoQ — an antioxidant — shows some promise in fighting ...
- Antioxidant drug knocks down multiple sclerosis-like disease in miceon December 27, 2013 at 7:30 pm
Researchers at Oregon Health & Science University have discovered that an antioxidant designed by scientists ... helps symptoms in mice that have a multiple sclerosis-like disease. The antioxidant -- ...
- MitoQ® Launches Advanced Third Generation CoQ Antioxidant Dietary Supplementon December 2, 2013 at 10:00 pm
NEW YORK, Dec. 3, 2013 /PRNewswire/ -- MitoQ® Limited is excited to announce the release of their newest offering, MitoQ® Targeted Antioxidant Dietary Supplement. Published studies show that ...
- MitoQ, The Anti-aging Skin Cream with World-leading Scienceon April 29, 2013 at 10:05 pm
Yet that is exactly what owners of MitoQ are setting out to do with their skin cream. MitoQ is a skin cream which features world leading technology to slow the ageing process of skin cells ...
via Bing News