This discovery represents a major innovation
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.
This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor and director of the joint UC San Diego-KACST Center of Excellence in Nanomedicine. Up to now, she said, only a handful of strategies using light-triggered release from nanoparticles have been reported.
The mechanism, described in the April 1, 2014 online issue of ACS Nano, employs near-infrared (NIR) light from a low-power laser to heat pockets of water trapped within non-photo-responsive polymeric nanoparticles infused with drugs. The water pockets absorb the light energy as heat, which softens the encapsulating polymer and allows the drug to be released into the surrounding tissue. The process can be repeated multiple times, with precise control of the amount and dispersal of the drug.
“A key advantage of this mechanism is that it should be compatible with almost any polymer, even those that are commercially available,” said Mathieu Viger, a post-doctoral fellow in Almutairi’s laboratory and co-lead author of the study. “We’ve observed trapping of water within particles composed of all the biodegradable polymers we’ve so far tested.”
The method, noted Viger, could thus be easily adopted by many biological laboratories.
The combined use of hydrated polymers and near-infrared light appears to resolve a host of technological and health barriers that have hindered previous, similar approaches. Earlier efforts to use NIR-triggered release have not been widely exploited because they required special designer polymers, expensive high-powered lasers and/or the co-encapsulation of inorganic particles whose safety in the body remains questionable.
The new method described by Almutairi and colleagues in the departments of Mechanical and Aerospace Engineering, Neuroscience, and Chemistry and Biochemistry at UC San Diego uses NIR at a vibrational wavelength cued to excite water molecules, which absorb the optical energy and convert it to heat. NIR is capable of penetrating biological tissues to greater depths than visible or ultraviolet light.
Co-lead author Wangzhong Sheng, a graduate student in Department of Mechanical and Aerospace Engineering, explained the selectivity of heating by comparing the trapped water within particles to a glass of water and the surrounding water within the solution or tissue to a bathtub. The smaller amount of water is heated much more rapidly because of the enormous volume difference.
An obvious use of the method, said Almutairi, is light-triggered drug delivery, but with more research, she anticipates the new method could provide a variety of industrial, medical and scientific applications, including “any technological application requiring that chemistry be controlled in time and in space, such as in catalysis or self-repairing materials or light-activated sunscreens or pesticide dosing.”
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Transdermal Drug Delivery System Market Analysis, Size, Share, Growth, Trends and Forecast to 2023on December 1, 2019 at 10:24 pm
A comprehensive research report created through extensive primary research (inputs from industry experts, companies, stakeholders) and secondary research, the report aims to present the analysis of ...
- Drug Delivery Across Blood Brain Barrier Market Poised to Surge Billion By 2026: Grand View Research, Incon November 30, 2019 at 8:20 am
According to report published by Grand View Research, The global drug delivery across blood brain barrier (BBB) market size was estimated at USD 582.0 million in 2018. The global drug delivery across ...
- Global Transdermal Drug Delivery Market Analysis and Outlook Study, 2019 to 2025 - ResearchAndMarkets.comon November 29, 2019 at 11:51 am
DUBLIN--(BUSINESS WIRE)--The "Transdermal Drug Delivery - Market Analysis, Trends, and Forecasts" report has been added to ResearchAndMarkets.com's offering. The Transdermal Drug Delivery market ...
- Controlled Release Drug Delivery Market - Detailed Insights of Top Manufacturer, Region, Type and Application 2019-2026on November 28, 2019 at 4:46 am
Nov 28, 2019 (AmericaNewsHour) -- The global controlled release drug delivery market size is set to witness a higher revenue share resulting into a strengthened CAGR during the forecast period, 2019 ...
- Global Injectable Drug Delivery Market and Outlook 2019-2025 - ResearchAndMarkets.comon November 27, 2019 at 4:10 pm
The "Injectable Drug Delivery Market Size, Outlook and Growth Opportunities, 2019- 2025" report has been added to ResearchAndMarkets.com's offering. This report includes the latest predictions of the ...
- Global Transdermal Drug Delivery Systems Market, Outlook and Forecast 2019-2025 - ResearchAndMarkets.comon November 27, 2019 at 4:06 pm
The "Transdermal Drug Delivery System Market Size, Outlook and Growth Opportunities, 2019-2025" report has been added to ResearchAndMarkets.com's offering. This report includes the latest predictions ...
- New technique could help produce uniform nanoparticles for use in drug delivery systemson November 27, 2019 at 10:07 am
A new technique in chemistry could pave the way for producing uniform nanoparticles for use in drug delivery systems. Scientists have been investigating how to make better use of nanoparticles in ...
- Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatmenton November 26, 2019 at 3:03 am
Ketoprofen delivery was mainly governed by the Higuchi model dependent on several factors ... The loading samples were labeled as Sr/PTA-MOFs-Ketoprofen. The drug release was studied by dispersing 20 ...
- Health Beat: New drug delivery relieves chronic sinusitison November 22, 2019 at 12:41 pm
The new part is simply the delivery system. Piccirillo said this is available right now to patients who are interested. He suggested patients talk to their doctor about how to add the powder form of ...
- Global Drug-delivery Smart Pill Market 2019 Trends, Market Share, Industry Size, Opportunities, Analysis And Forecast To 2025on November 22, 2019 at 7:17 am
Wiseguyreports.Com Adds “Drug-delivery Smart Pill– Global Market Share, Industry Analysis, Competitive Landscape, Strategies And Forecast To 2025” To Its Research Database. A Recent Report Found On ...
via Bing News