New drug delivery method targets cancer cells – not the entire body – and limits chemotherapy side effects
Chemotherapeutic drugs excel at fighting cancer, but they’re not so efficient at getting where they need to go.
They often interact with blood, bone marrow and other healthy bodily systems. This dilutes the drugs and causes unwanted side effects.
Now, researchers are developing a better delivery method by encapsulating the drugs in nanoballoons – which are tiny modified liposomes that, upon being struck by a red laser, pop open and deliver concentrated doses of medicine.
Described April 3 in the journal Nature Communications, the innovation could improve cancer treatment, reduce its side effects and boost research about the disease, which annually kills millions of people worldwide.
The paper, “Porphyrin-phospholipid (PoP) liposomes permeabilized by near-infrared light,” is available here:
“Why PoP-liposomes, or nanoballoons, open in response to an otherwise harmless red laser is still a bit of a mystery to us, but we have definitely unearthed a new and unique phenomenon,” said corresponding author Jonathan Lovell, PhD, UB assistant professor of biomedical engineering. “Its potential for improving how we treat cancer is immense.”
Additional authors include students and a research technician at UB, as well as collaborators from the University at Albany; Roswell Park Cancer Institute in Buffalo; and the University of Waterloo and McMaster University, both in Ontario, Canada.
Roughly 1,000 times thinner than human hair, nanoballoons consist of porphyrin, an organic compound, and phospholipid, a fat similar to vegetable oil. Like conventional chemotherapy, they would be delivered to patients intravenously.
But because the nanoballoons encapsulate the anti-cancer drugs, they diminish the drugs’ interaction with healthy bodily systems.
In laboratory experiments performed with mice, Lovell hits the nanoballoon with a red laser at the target site in the body. The laser triggers the nanoballoons to pop open and release the drugs. As soon as the laser is turned off, the nanoballoons close, taking in proteins and molecules that might induce cancer growth. Doctors could then be able to retrieve the nanoballoons by drawing blood or taking a biopsy.
Thus, the nanotechnology could provide a “chemical snapshot” of the tumor’s environment, which otherwise is very difficult to assess.
“Think of it this way,” Lovell said. “The nanoballoon is a submarine. The drug is the cargo. We use a laser to open the submarine door which releases the drug. We close the door by turning the laser off. We then retrieve the submarine as it circulates through the bloodstream.”
Lovell will continue fundamental studies to better understand why the treatment works so well in destroying tumors in mice, and to optimize the process. Human trials could start within five years, he said.
The Latest on: Drug delivery method
via Google News
The Latest on: Drug delivery method
- Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printingon September 8, 2019 at 3:17 pm
Therefore, this is a simple and promising method which can be adapted for further development of microneedle-based drug delivery systems. While additive manufacturing generally allows for fabrication ...
- Lexaria Bioscience Corp. (CSE: LXX) (OTCQX: LXRP) Featured in NetworkNewsAudio Publication Discussing Innovative Drug-Delivery Discoveryon September 6, 2019 at 6:30 am
Lexaria Bioscience Corp. (CSE:LXX) (OTCQX:LXRP) Featured in NetworkNewsAudio Publication Discussing Innovative Drug-Delivery Discovery ... out-licenses its disruptive delivery technology, which ...
- Drug Delivery in Cancer, 2019: Technologies, Markets & 238 Companies - Global Forecast to 2028on September 6, 2019 at 1:20 am
Several innovative methods of drug delivery are used in cancer. These include use of microparticles as carriers of anticancer agents. These may be injected into the arterial circulation and guided ...
- Lexaria Bioscience Corp. (CSE: LXX) (OTCQX: LXRP) Featured in NetworkNewsWire Publication Reporting on Momentous Advances in Drug-Delivery Innovationon September 5, 2019 at 5:30 am
To view the full publication, titled “Innovative Drug-Delivery Systems Benefit Patients ... has developed and out-licenses its disruptive delivery technology, which promotes healthier ingestion ...
- Drug Delivery Systems Market to hit US$ 900 billion by 2025 - TMRon September 5, 2019 at 2:47 am
Hoffman-La Roche, GlaxoSmithKline plc, and Antares Pharma, Inc. are some of the renowned companies in the global drug delivery systems market. Experts at Transparency Market Research (TMR) have ...
- Innovative Drug-Delivery Systems Benefit Patients and Businesseson September 4, 2019 at 5:35 am
that effectiveness is closely associated with the drug-delivery technology used, and innovation in this space may have a huge impact on how successful a drug can be. New methods of delivery could make ...
- Pharmaceutical Drug Delivery Systems Market Size, Share, Growth and Industry Forecast to 2025on September 4, 2019 at 2:36 am
The drug delivery is a procedure for transferring pharmaceuticals drugs into the body. The most commonly used methods are steady, controlled and targeted drug delivery. There are various drugs which ...
- Using mesoporous materials as nanovehicle for improved drug deliveryon September 3, 2019 at 8:28 pm
... research on DOX as a model drug and introduced a reverse method in which organic groups are grafted after removing the template agent. This has potential applications in the drug delivery field ...
- Government of Canada invites small businesses to develop new solutions for medical drug delivery and carbon manufacturingon September 3, 2019 at 12:11 pm
Liposomes act as drug delivery vehicles and can be used for indications such ... lighter composite materials than those currently available with existing manufacturing methods. These ceramic powders ...
- Insights into Direct Delivery of Immunotherapy to Brain Tumorson August 30, 2019 at 5:35 am
"Current clinically proven methods of brain cancer immunotherapy do not ensure ... lymphocytes and microglial cells can then attack and destroy the cancer cells. "Drug delivery is the major obstacle ...
via Bing News