A team at the University of Louisville has taken bioprinting a step farther by creating a working 3D printed human heart made of fat cells
Imagine your beating, pumping heart, working hard right this moment to keep you alive. Now think of a future where, if your heart failed or has a defect, you could get one that works better and lasts longer.
It sounds like something out of a sci-fi movie, but researchers at the University of Louisville have moved a step closer in this direction by using a 3D printer to make working parts of a human heart, using fat cells and collagen.
“We are utilizing printing and other biological manufacturing techniques to build these different parts of the heart,” Dr. Stuart Williams told TechRepublic. Williams is the chief of the Bioficial Heart program at the University of Louisville’s Cardiovascular Innovation Institute in Louisville, Kentucky.
He added that the team has not reached the point where they put together the valves and the blood vessels, or any other products. They are solely focused on creating working pieces of the muscle.
Williams described the process as similar to building an airplane. Airplanes aren’t built in the traditional 3D printing sense, where you would start with the wheels at the bottom and build up. The parts for an airplane are made piece by piece, then assembled together.
Same with a human heart, which is a complex muscle. It can’t be built at once, so each part — the valves, large blood vessels, small blood vessels, electrical conducting system — is built and assembled together with a giant, intricate 3D printer.
To print the heart, Williams and his team use collagen and fat cells. One liter of fat from someone can give them a huge number of cells that can be directly translated to patients, he said.
“[We are] taking a piece of fat, isolating regenerative cells in the fat, utilizing those, then mixing factorized cells with collagen, and it prints.”
What’s even more innovative is the “six-axis” printer Williams helped build that makes the heart one section at a time. This “robot” can build the specific parts, then move them around and place them in their correct positions within the muscle.
The U of L lab is the only one in the world that has this intricate of a 3D printer, made specifically for bioprinting. Williams calls it a “bioassembly tool.”
The Latest on: Bioprinting
via Google News
The Latest on: Bioprinting
- Preparation and characterization of nanoclay-hydrogel composite support-bath for bioprinting of complex structureson March 24, 2020 at 3:31 am
Three-dimensional bioprinting of cell-laden hydrogels in a sacrificial support-bath has recently emerged as a potential solution for fabricating complex biological structures. Physical properties of ...
- Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalentson March 24, 2020 at 3:03 am
Extrusion-based bioprinting presents a promising fabrication method for bone replacement. It allows for the production of large-volume constructs, which can be tailored to individual tissue defect ...
- Researchers Find "Groovy" Way to Grow Human Tissueon March 19, 2020 at 1:28 am
Researchers have developed a new bioprinting method that allows researchers to grow different types of living cells at the same time into implants using the same foundational technologies. The method, ...
- Global 3D Bioprinting Market Forecasts, 2020-2025on March 18, 2020 at 8:16 am
Dublin, March 18, 2020 (GLOBE NEWSWIRE) -- The "3D Bioprinting Market - Growth, Trends and Forecasts (2020 - 2025)" report has been added to ResearchAndMarkets.com's offering. The Global 3D ...
- Global 3D Bioprinting Market Forecasts, 2020-2025on March 18, 2020 at 8:13 am
3D bioprinters are of the highest importance for drug testing and clinical trial applications expected to drastically reduce the need for animal trials (therefore not only being ethically beneficial ...
- Suction forces enable precise bioprintingon March 17, 2020 at 4:45 am
The approach, dubbed aspiration-assisted bioprinting, could be used for applications such as regenerative medicine, tissue engineering and in vitro modelling of human diseases. In 3D bioprinting, cell ...
- Hydrogels in Bioprinting Today: Design Strategies for Emerging Applicationson March 16, 2020 at 1:32 pm
Researchers from Germany and China are working together to study the use of hydrogels in bioprinting further, outlining their findings in the recently published ‘3D printing of hydrogels: Rational ...
- Bioprinting Market to 2025 Top Player Profiles -Organovo Holding Inc, Cyfuse Biomedical, BioBots, Luxexcel Group BVon March 16, 2020 at 5:03 am
The global bioprinting market is expected to witness significant growth during the forecast period due to factors such as technological advancements for manufacturing customized products ...
- 3D Bioprinting Peptigels to Increase Cell Viabilityon March 11, 2020 at 1:39 am
In 2014, due to a demand for their materials, our company, Manchester BIOGEL was founded to enable these hydrogels to be readily available to researchers wishing to create new opportunities in the ...
via Bing News