Wellcome Trust-funded stem cell research has produced red blood cells fit for transfusion into humans, paving the way for the mass production of blood
It is the stuff of gothic science fiction: men in white coats in factories of blood and bones.
But the production of blood on an industrial scale could become a reality once a trial is conducted in which artificial blood made from human stem cells is tested in patients for the first time.
It is the latest breakthrough in scientists’ efforts to re-engineer the body, which have already resulted in the likes of 3d-printed bones and bionic limbs.
Marc Turner, the principal researcher in the £5 million programme funded by the Wellcome Trust, told The Telegraph that his team had made red blood cells fit for clinical transfusion.
Prof Turner has devised a technique to culture red blood cells from induced pluripotent stem (iPS) cells – cells that have been taken from humans and ‘rewound’ into stem cells. Biochemical conditions similar to those in the human body are then recreated to induce the iPS cells to mature into red blood cells – of the rare universal blood type O-.
“Although similar research has been conducted elsewhere, this is the first time anybody has manufactured blood to the appropriate quality and safety standards for transfusion into a human being,” said Prof Turner.
There are plans in place for the trial to be concluded by late 2016 or early 2017, he said. It will most likely involve the treatment of three patients with Thalassaemia, a blood disorder requiring regular transfusions. The behaviour of the manufactured blood cells will then be monitored.
“The cells will be safe,” he said, adding that there are processes whereby cells can be removed.
The technique highlights the prospect of a limitless supply of manufactured type O- blood, free of disease and compatible with all patients.
The Latest on: Artificial blood
via Google News
The Latest on: Artificial blood
- Bionic heart for testing prosthetic valves, cardiac deviceson February 4, 2020 at 4:23 am
Engineers at MIT and elsewhere have developed a bionic heart that offers a more realistic model for testing artificial valves and other cardiac devices. A close-up of a synthetic matrix of soft ...
- Artificial pericardial tissue from the 3D printeron February 4, 2020 at 3:52 am
In the future, novel polymers should make it possible to individually manufacture artificial elastic tissue replacements for pericardium, heart valves or blood vessels. In the PolyKARD project, ...
- Scientists create artificial 'virus' to break walls of resistant bacteria and defeat infectionon February 4, 2020 at 3:35 am
An artificial 'virus' that burrows through the walls of bacteria without being spotted ... But the new research from Dr Ryadnov and his colleagues could provide a new weapon in the fight against ...
- Artificial Intelligence may be the key to identify neurodegenerative diseases' progresson February 2, 2020 at 4:09 pm
Montreal (Quebec) [Canada], Feb 2 (ANI): Artificial intelligence (AI) algorithms show the potential to predict neurodegenerative ... and the Ludmer Centre for Neuroinformatics and Mental Health used ...
- AI-analyzed blood test can predict the progression of neurodegenerative diseaseon January 30, 2020 at 5:10 pm
A new study shows artificial intelligence (AI) analysis of blood samples can predict and explain disease progression, which could one day help doctors choose more appropriate and effective treatments ...
- Artificial Wombs Aren’t a Sci-Fi Horror Storyon January 30, 2020 at 7:15 am
This setup is an artificial womb, in a sense—it’s just nothing like a real womb. A proper artificial womb would bypass those immature lungs, reoxygenating the baby’s blood via an umbilical catheter, ...
- Dual-hormone artificial pancreas ‘next logical treatment’ for type 1 diabeteson January 29, 2020 at 5:42 am
Haidar and colleagues assessed how frequently a cohort of 28 adults with type 1 diabetes (mean age, 25 years; 43% women) were able to maintain blood glucose levels between 3.9 mmol/L and 10 mmol/L ...
- AI-based blood tests to predict neurodegenerative disease progressionon January 28, 2020 at 8:32 pm
A recent study has shown the effectiveness of Artificial Intelligence (AI) algorithms in predicting the progression ... University and the Ludmer Centre for Neuroinformatics and Mental Health used an ...
- Artificial pancreas uses refillable oxygen tank to better-produce insulinon January 28, 2020 at 10:58 am
Once implanted under the skin, the ßAir is claimed to continuously monitor blood glucose levels, utilizing the oxygen-fed pancreatic cells to produce and deliver insulin whenever necessary. According ...
- Can A.I. blood analysis predict Alzheimer’s progress?on January 28, 2020 at 9:19 am
Artificial intelligence analysis of blood samples can predict and explain neurodegenerative disease progression, researchers report. The technique could one day help doctors choose more appropriate ...
via Bing News