Using an inexpensive 3-D printer, biomedical engineers have developed a custom-fitted, implantable device with embedded sensors that could transform treatment and prediction of cardiac disorders.
Igor Efimov, PhD, at the School of Engineering & Applied Science at Washington University in St. Louis and an international team of biomedical engineers and materials scientists have created a 3-D elastic membrane made of a soft, flexible, silicon material that is precisely shaped to match the heart’s epicardium, or the outer layer of the wall of the heart. Current technology is two-dimensional and cannot cover the full surface of the epicardium or maintain reliable contact for continual use without sutures or adhesives.
The team can then print tiny sensors onto the membrane that can precisely measure temperature, mechanical strain and pH, among other markers, or deliver a pulse of electricity in cases of arrhythmia. Those sensors could assist physicians with determining the health of the heart, deliver treatment or predict an impending heart attack before a patient exhibits any physical signs.
“Each heart is a different shape, and current devices are one-size-fits-all and don’t at all conform to the geometry of a patient’s heart,” says Efimov, the Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering. “With this application, we image the patient’s heart through MRI or CT scan, then computationally extract the image to build a 3-D model that we can print on a 3-D printer. We then mold the shape of the membrane that will constitute the base of the device deployed on the surface of the heart.”
Ultimately, the membrane could be used to treat diseases of the ventricles in the lower chambers of the heart or could be inserted inside the heart to treat a variety of disorders, including atrial fibrillation, which affects 3 million to 5 million patients in the United States.
“Currently, medical devices to treat heart rhythm diseases are essentially based on two electrodes inserted through the veins and deployed inside the chambers,” says Efimov, also a professor of radiology and of cell biology and physiology at the School of Medicine. “Contact with the tissue is only at one or two points, and it is at a very low resolution. What we want to create is an approach that will allow you to have numerous points of contact and to correct the problem with high-definition diagnostics and high-definition therapy.”
Co-leading the team with Efimov is John Rogers, PhD, the Swanlund Chair and professor of materials science and engineering and director of the F. Seitz Materials Research Laboratory at the University of Illinois at Urbana-Champaign. Rogers, who developed the transfer printing technique, developed the sensors using semiconductor materials including silicon, gallium arsenide and gallium nitride, along with metals, metal oxides and polymers.
Recently, Google announced its scientists had developed a type of contact lens embedded with sensors that could monitor glucose levels in patients with diabetes. Efimov says the membrane his team has developed is a similar idea, though much more sophisticated.
“Because this is implantable, it will allow physicians to monitor vital functions in different organs and intervene when necessary to provide therapy,” he says. “In the case of heart rhythm disorders, it could be used to stimulate cardiac muscle or the brain, or in renal disorders, it would monitor ionic concentrations of calcium, potassium and sodium.”
The Latest on: Transformative device for heart treatment
via Google News
The Latest on: Transformative device for heart treatment
- Heart Pump Devices Market Trends Analysis, Future Growth Dynamics, Share Value, Application and Key Sales Insights By 2023on November 29, 2019 at 6:43 am
The heart pump devices market in Europe is anticipated to have the second-largest share in the market during the forecast period chiefly on account of increasing obesity rates, increasing prevalence ...
- How Can Big Pharma Make Amends for the Opioid Epidemic?on November 22, 2019 at 3:18 am
What I learned was that, nestled within this crisis (if you knew where to look), people were taking responsibility for what had happened to them and doing so in a transformative way ... and regularly ...
- Congestive Heart Failure (CHF) Treatment Devices Market Analysis by Key Players, End Users, Application and CAGR Value Forecast to 2028on November 19, 2019 at 9:43 pm
Nov 20, 2019 (WiredRelease via COMTEX) -- “Global Congestive Heart Failure (CHF) Treatment Devices Market” report includes the world’s crucial region market share, size (volume), recent trends ...
- Congestive Heart Failure (CHF) Treatment Devices Market by Trends, Key Players, Segmentation, Forecast to 2026on November 14, 2019 at 9:23 am
Nov 14, 2019 (Global QYResearch via COMTEX) -- The global Congestive Heart Failure (CHF) Treatment Devices market is valued at 11000 million US$ in 2018 is expected to reach 17200 million US$ by the ...
- Dassault Systèmes and the FDA Extend Collaboration to Inform Cardiovascular Device Review Process and Accelerate Access to New Treatmentson July 23, 2019 at 10:09 pm
An in silico clinical trial is underway with the 3DEXPERIENCE platform to evaluate the Living Heart ... to spur medical device innovation by enabling innovative, new product designs Both Dassault ...
- Wearable devices transform cardiac care and treatmenton February 26, 2019 at 4:00 pm
From smartphone apps that measure your pulse and heart rhythm to ... the Apple Watch or any other device, he believes the technology could be impactful for enhancing patient care. “This feature has ...
- 3-D printer creates transformative device for heart treatmenton February 24, 2014 at 4:02 pm
Efimov and a team of researchers are developing a custom-fitted, implantable device that can deliver treatment or predict an impending heart attack before a patient shows any physical symptoms.
- 3-D Printer Creates Transformative Device for Heart Treatmenton February 24, 2014 at 4:00 pm
Using an inexpensive 3-D printer, biomedical engineers have developed a custom-fitted, implantable device with embedded sensors that ... physicians with determining the health of the heart, deliver ...
- 3-D printer creates transformative device for heart treatmenton February 24, 2014 at 4:00 pm
Efimov and a team of researchers are developing a custom-fitted, implantable device that can deliver treatment or predict an impending heart attack before a patient shows any physical symptoms. “Each ...
- 3-D printer creates transformative device for heart treatment (w/ Video)on February 24, 2014 at 4:00 pm
deliver treatment or predict an impending heart attack before a patient exhibits any physical signs. The findings were published online in Nature Communications Feb. 25, 2014. "Each heart is a ...
via Bing News