Platelets, whose primary function is to prevent bleeding, are vital for treating various forms of trauma and blood diseases.
However, they can only be obtained through blood donations at present. Researchers reporting online February 13 in the Cell Press journal Cell Stem Cell recently found a way to create platelets without the need for donated blood, an advance that could possibly erase supply shortages and ensure platelet treatments for all who need them.
The supply of donated platelets, which have a short shelf life and must be kept at room temperature, is often insufficient to meet clinical needs. In addition, while transfused platelets do not typically need to be immune-matched to patients, repeated transfusion of unmatched platelets leads to an immune reaction that eventually renders patients unresponsive to platelet transfusion therapy.
To address these limitations, investigators from Japan developed a strategy to derive functional platelets from human induced pluripotent stem cells. Induced pluripotent stem cells can be generated from various types of cells in the body, and they can in turn be coaxed to develop into nearly any other cell type. In the current study, the approach involved genetically manipulating such stem cells to become stable immortalized lines of platelet-producing cells called megakaryocyte progenitors.
The megakaryocyte progenitors could produce large quantities of platelets with clotting capabilities that were similar to those of donated platelets. Unlike freshly donated platelets, though, the immortalized megakaryocyte progenitors could be expanded and frozen for long-term storage.
“Here we established a method to achieve the long-term self-replication of megakaryocyte progenitors as an immortalized cell line, which could eventually contribute to large-scale cultivation and production of platelets,” says senior author Dr. Koji Eto of Kyoto University and the University of Tokyo.
The Latest on: Platelet supply
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The Latest on: Platelet supply
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- Blood Supply Low In Coronavirus, Donation Drives In Livingstonon March 27, 2020 at 5:00 am
Saint Barnabas Medical Center and the Township of Livingston are teaming up to hold two blood and platelet drives.
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- Coronavirus in Cincinnati: Sunday blood donations shore up local supply, but more neededon March 23, 2020 at 12:39 pm
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- Blood supply remains stable, as Irish Blood Transfusion Service debunks hoax messageon March 23, 2020 at 11:07 am
The hoax message said blood and platelet stocks were low and urged people to donate ... message originated in the Munster region and did not go beyond that. The blood supply remains sufficient at this ...
- COVID-19 closures hinder blood supply to Montana, Wyoming hospitalson March 22, 2020 at 4:45 am
School closures and business shutdowns due to the novel coronavirus contribute to a state-wide blood shortage for hospitals.
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