Duke researchers use gene therapy to direct stem cells into becoming new cartilage on a synthetic scaffold even after implantation into a living body
By combining a synthetic scaffolding material with gene delivery techniques, researchers at Duke University are getting closer to being able to generate replacement cartilage where it’s needed in the body.
Performing tissue repair with stem cells typically requires applying copious amounts of growth factor proteins—a task that is very expensive and becomes challenging once the developing material is implanted within a body. In a new study, however, Duke researchers found a way around this limitation by genetically altering the stem cells to make the necessary growth factors all on their own.
They incorporated viruses used to deliver gene therapy to the stem cells into a synthetic material that serves as a template for tissue growth. The resulting material is like a computer; the scaffold provides the hardware and the virus provides the software that programs the stem cells to produce the desired tissue.
The study appears online the week of Feb. 17 in the Proceedings of the National Academy of Sciences.
Farshid Guilak, director of orthopaedic research at Duke University Medical Center, has spent years developing biodegradable synthetic scaffolding that mimics the mechanical properties of cartilage. One challenge he and all biomedical researchers face is getting stem cells to form cartilage within and around the scaffolding, especially after it is implanted into a living being.
The traditional approach has been to introduce growth factor proteins, which signal the stem cells to differentiate into cartilage. Once the process is under way, the growing cartilage can be implanted where needed.
“But a major limitation in engineering tissue replacements has been the difficulty in delivering growth factors to the stem cells once they are implanted in the body,” said Guilak, who is also a professor in Duke’s Department of Biomedical Engineering. “There’s a limited amount of growth factor that you can put into the scaffolding, and once it’s released, it’s all gone. We need a method for long-term delivery of growth factors, and that’s where the gene therapy comes in.”
Read more . . .
The Latest on: Replacement Tissue
Our Organovo Stock Prediction in 2019 (Buy or Sell?) - Investing Daily
February 18, 2019 - Our Organovo Stock Prediction in 2019 (Buy or Sell?) Investing DailyThere is a long waiting list for human patients in need of healthy organs. Soon, organ replacement may be as simple as bioprinting the required body tissue.
Cell replacement therapies may help treat Parkinson's disease - The New Indian Express
February 18, 2019 - Cell replacement therapies may help treat Parkinson's disease The New Indian ExpressThe first systematic clinical transplantation trials using pluripotent stem cells as donor tissue were initiated in Japan in 2018.
Tissue-Replacement Products Market 2019: by Top Key Players- StrataGraft, Edwards Lifesciences, Medtronic, Arthrex - Spot Herld
February 8, 2019 - Tissue-Replacement Products Market 2019: by Top Key Players- StrataGraft, Edwards Lifesciences, Medtronic, Arthrex Spot Herld[Los Angeles, United State, 02/08/2019]—The global Tissue-Replacement Products market is expected to surge at a steady CAGR in the coming years, states ...
Regenerative Medicine Market Key Futuristic Trends and Competitive Landscape By Organogenesis Inc., Osiris Therapeutics, Inc., Vericel Corporation, Stryker Corporation and NuVasive, Inc - openPR
February 18, 2019 - Regenerative Medicine Market Key Futuristic Trends and Competitive Landscape By Organogenesis Inc., Osiris Therapeutics, Inc., Vericel Corporation, Stryker Corporation and NuVasive, Inc openPRRegenerative Medicine Market Analysis According to Verified Market Research, the Global Regenerative Medicine Market was valued at USD 19.10 Billion in ...
Cardiac Valve Market 2019 Global Forecasts Analysis, Company Profiles, Competitive Landscape and Key Regions 2023 Available at Market Research Future | - Medgadget
February 18, 2019 - Cardiac Valve Market 2019 Global Forecasts Analysis, Company Profiles, Competitive Landscape and Key Regions 2023 Available at Market Research Future | MedgadgetCardiac valve or heart valve allows blood to flow in only one direction through the heart. Human heart consists of four valves. These valves open and.
Global Biomaterials Market to Witness a CAGR of 14.4% during 2018-2024 - GlobeNewswire
February 1, 2019 - Global Biomaterials Market to Witness a CAGR of 14.4% during 2018-2024 GlobeNewswireNEW YORK, Feb. 01, 2019 (GLOBE NEWSWIRE) -- Global biomaterials market was valued at USD 82.6 billion in 2017, and is likely to expand to USD 215.3 ...
Global Soft Tissue Allografts Market- Segmented by Capacity, Production, Value, Consumption, Application and Region, Forecast To 2023 - Times Ohio
February 18, 2019 - Global Soft Tissue Allografts Market- Segmented by Capacity, Production, Value, Consumption, Application and Region, Forecast To 2023 Times OhioThe Soft Tissue Allografts market report provides the main data on the state of the industry and is a valuable source of guidance and direction for industries and ...
How bacteria, dental cleaning endangered and saved heart - Port St. Joe Star
February 18, 2019 - How bacteria, dental cleaning endangered and saved heart Port St. Joe StarLAFAYETTE, La. (AP) " Jonathan Hunter will be the first to tell you to go to the doctor, and not just because he is one.The family medicine doctor and Rapides ...
Miss Berks County winners advance to state competitions - Reading Eagle
February 18, 2019 - Miss Berks County winners advance to state competitions Reading EagleThe causes they advocate for are animal safety and adoption; organ and tissue donation; and awareness of adolescent depression and suicide.
Treating spinal pain with replacement discs made of 'engineered living tissue' moves closer to reality - Medical Xpress
November 21, 2018 - Treating spinal pain with replacement discs made of 'engineered living tissue' moves closer to reality Medical XpressFor the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for ...