A chemist based at the University of Copenhagen has just taken out a patent for a drug that can make previously multidrug-resistant bacteria responsive to antibiotics once again.
Jørn Bolstad and his chemist colleagues hope that the substance will soon be able to tackle the tremendous problems associated with multidrug resistant tuberculosis (MDR-TB). But first, they need to find investors interested in getting the substance onto the market.
Before the development of penicillin, people dropped like flies in response to minor infections: in the lungs, in small cuts. Even pimples could grow to boils that killed. But one of the main killers prior to the discovery of antibiotics was tuberculosis.
The deadly infectious disease that typically affects the lungs has returned. It has developed a resistance to the majority of antibiotics that would otherwise kill the tuberculosis bacteria. Currently, the disease does not pose an imminent threat to Denmark or the West. However, resistant strains of the bacteria are nearing the region’s borders. This is one of the reasons why doctors around the world are busy trying to solve the problem of drug resistance.
The bacteria shed killing substances
While those bacteria that have developed a resistance remain vulnerable to antibiotics, they have developed an ability to shed bacteria killing substances before any damage is done to them. Colloquially, this is referred to as pooping the substance out, but the scientific formulation is that these bacteria activate an efflux pump.
Jørn Bolstad Christensen has isolated a substance able to block the efflux pump so that an antibiotic remains in bacteria until the bacteria dies.
You could say that we cure bacteria of their resistance, and slay them with antibiotics, explains Associate Professor Jørn Bolstad Christensen.
From antipsychotic to killing bacteria
Working with doctors Jette Kristiansen from the University of Southern Denmark and Oliver Hendricks from the King Christian X’s Hospital for Rheumatic Diseases in Gråsten, Denmark, Jørn Bolstad Christensen discovered that Thioridazin, an antipsychotic drug, was able to kill bacteria without any noticeably harmful effects upon humans. Still, the chemists had an idea that could make the substance more benign.
We now have a substance that is able to block the bacteria’s efflux pump. At very most, recipients of the medication may become slightly sluggish. This is also because very small doses are needed to affect the bacteria, says Jørn Bolstad Christensen.
Researchers hope for quick approval
Because Thioridazin is an approved drug, the research team hopes that the new anti-resistance medication, JEK 47, will be approved without going through the entire process that new pharmaceuticals are typically subjected to. If this is the case, JEK 47 will most likely be a cheap medication that a pharmaceuticals manufacturer could release quickly. However if an investor does not show interest, Christensen is certain about his next step.
The Latest on: Antibiotic resistance
via Google News
The Latest on: Antibiotic resistance
- A new antibiotic has been hiding in the gut of a tiny worm. It may be our best weapon against drug-resistant bacteria.on November 21, 2019 at 5:21 am
Researchers at Northeastern have discovered a new antibiotic that could treat infections caused by some of the nastiest superbugs humanity is facing in the antibiotic resistance crisis. After two ...
- What is antibiotic resistance? And when will it strike?on November 21, 2019 at 2:27 am
Antibiotic resistance is on the rise, with a growing number of bacteria no longer responding to the once life-saving drugs. The World Health Organization calls it “one of the biggest threats to global ...
- Antimicrobial resistance in pathogenic aerobic bacteria causing surgical site infections in Mbarara regional referral hospital, Southwestern Ugandaon November 21, 2019 at 2:15 am
Surgical site infections (SSI) remain a common postoperative complication despite use of prophylactic antibiotics and other preventive measures, mainly due to increasing antimicrobial resistance. Here ...
- Why the CDC warns antibiotic-resistant fungal infections are an urgent health threaton November 20, 2019 at 4:27 pm
Surgeons operated to remove the abscess. Two days later, test results revealed that the abscess was caused by a fungus called Candida that was resistant to echinocandins, our most powerful drugs ...
- Characterization of antibiotic resistance genes in the species of the rumen microbiotaon November 20, 2019 at 3:26 am
Infections caused by multidrug resistant bacteria represent a therapeutic challenge both in clinical settings and in livestock production, but the prevalence of antibiotic resistance genes among the ...
- CDC expert: 'Antibiotic resistance is worse than we previously thought'on November 18, 2019 at 10:38 am
A superbug, otherwise known as an antibiotic-resistant infection, can be potentially lethal. And according to a new CDC report, there are more than 2.8 million superbugs in the U.S. each year, with ...
- The rise of superbugs: Facing the antibiotic resistance crisison November 18, 2019 at 9:05 am
While medical research has helped us overcome many health threats, we now face a new type of crisis: Many dangerous bacteria are becoming resistant to the drugs meant to fight them. Where do we go ...
- Antibiotic Resistance: Rise Of Bacteria That Are Resistant To Antibiotics Alarms Medical Practitionerson November 18, 2019 at 3:10 am
Antibiotic resistance seems to create a growing problem among medical practitioners all over the world. Ailments that were once easy to treat have become unmanageable. Doctors explain that bacteria ...
- CDC Report Finds 35,000 Americans Die of Antibiotic-Resistant Infections Each Yearon November 15, 2019 at 10:19 am
An estimated 35,000 Americans die of antibiotic-resistant infections each year—one every 15 minutes—according to a stark new report from the Centers of Disease Control and Prevention that reveals that ...
- Antibiotic-resistant infections are deadlier than before. Here are 5 things to knowon November 14, 2019 at 10:40 am
Antibiotic-resistant infections are a bigger threat than previously thought, according to a new report from the Centers for Disease Control and Prevention. The report, Antibiotic Resistance Threats in ...
via Bing News