Researchers of the University of Konstanz the first to detect cancer cells using the olfactory senses
A research unit in an international cooperation project, led by the Konstanz-based neurobiologist and zoologist Professor Dr. Giovanni Galizia, has been the first to demonstrate that fruit flies are able to distinguish cancer cells from healthy cells via their olfactory sense. In an article, published on 6 January in the international scientific journal “Scientific Report” by the Nature Publishing Group, the researchers of the University of Konstanz and the University La Sapienza in Rome, Italy, describe how characteristic patterns in the olfactory receptors of transgenic Drosophilae can be recorded when activated by scent. Not only could a clear distinction be made between healthy cells and cancer cells; moreover, groupings could be identified among the different cancer cells.
“What really is new and spectacular about this result is the combination of objective, specific and quantifiable laboratory results and the extremely high sensitivity of a living being that cannot be matched by electronic noses or gas chromatography”, explains Giovanni Galizia. Natural olfactory systems are better suited to detecting the very small differences in scent between healthy cells and cancer cells. This fact has already been shown in experiments with dogs; however, these results are not objectifiable and are thus not applicable for a systematic medical diagnosis.
The researchers from Konstanz and Rome used the fact that single odourant molecules dock to the receptor neurons of the flies’ antenna and thus activate the neurons. In an imaging technique developed by the researchers, the different odourant molecules of the respective scent samples create different patterns of activated neurons, which fluoresce under the microscope when active, thanks to a genetic modification. In the experiment five different types of breast cancer cell lines were analysed, compared to healthy cells and clearly divergent patterns were generated. “As not only cancer cells can be distinguished from healthy cells, but also subgroups were discernible within the cancer cells, it seems that even different types of breast cancer cells can be differentiated via the antenna of Drosophila”, explains Alja Lüdke, member of the research unit and researcher at the University of Konstanz.
The Latest on: Cancer detection
via Google News
The Latest on: Cancer detection
- TTP plc selected for technology advisory partnership with Cancer Research UKon June 29, 2020 at 4:51 am
TTP, a leading independent technology and development company, announced that it has entered into a technology advisory partnership with Cancer Research UK.
- Endometrial Cancer Treatment Market Global Trends, Market Share, Industry Size, Growth, Opportunities and Market Forecast 2020 to 2027on June 29, 2020 at 4:14 am
The Global Endometrial Cancer Treatment Market is estimated to value over USD 12.4 billion by 2027 end with a CAGR of over 5.9% during the forecast period 2020 to 2027. Increasing awareness regarding ...
- New Agreements to Expand Access to 20 Lifesaving Cancer Medicines for Countries in Sub-Saharan Africa and Asiaon June 29, 2020 at 4:00 am
PRNewswire/ -- The American Cancer Society (ACS) and the Clinton Health Access Initiative (CHAI) today announced agreements with pharmaceutical ...
- NeoGenomics Launches Comprehensive Suite of Solid Tumor Liquid Biopsy Tests for Cancer Patientson June 29, 2020 at 4:00 am
(NASDAQ:NEO), a leading provider of cancer-focused genetic testing services, announced today the launch of three liquid biopsy tests for advanced non-small cell lung cancer, all solid tumor types (pan ...
- Pa. senator’s brain cancer battle inspires him to recognize survivors of the disease: ‘All are heroes'on June 29, 2020 at 3:46 am
Now in his eighth month of treatment for brain cancer, state Sen. Dave Arnold is one month away from completing his second cycle of chemotherapy. The Lebanon County Republican has had to endure a ...
- Peritumoral and intratumoral radiomic features predict survival outcomes among patients diagnosed in lung cancer screeningon June 29, 2020 at 2:15 am
The National Lung Screening Trial (NLST) demonstrated that screening with low-dose computed tomography (LDCT) is associated with a 20% reduction in lung cancer mortality. One potential limitation of ...
- Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohorton June 29, 2020 at 2:14 am
Eaton Myasthenic Syndrome (LEMS) Tumour Association Prediction (DELTA-P) score in a prospective cohort of patients with newly diagnosed LEMS to assess the clinical validity of this tool in a ...
- In the middle of a pandemic, a young Minnesota mother fights her second cancer diagnosison June 26, 2020 at 3:25 pm
Taylor Bustos said she'd never endure chemotherapy again. Less than a year later, she had to reckon with that promise.
- How a coat covered in asbestos led to one woman's cancer diagnosis 30 years lateron June 26, 2020 at 10:13 am
Heather Von St. James was diagnosed with malignant pleural mesothelioma, a cancer of the lining of the lungs, not long after her daughter was born in 2005. She only gained five pounds during her ...
- Digital breast cancer detection technology does not improve outcomeson June 24, 2020 at 8:00 am
Journal of the National Cancer Institute finds that breast cancer screening using digital mammography technology is not associated with improved health outcomes when compared to older film detection ...
via Bing News