“Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine”
Detecting dangerous blood clots, which can cause life-threatening conditions such as strokes and heart attacks, leading causes of death for men and women in the U.S., has been a coveted and elusive goal. But scientists are now reporting progress in the form of a simple urine test. Their study, in which they demonstrated that the test works using laboratory mice, appears in the journalACS Nano.
Sangeeta N. Bhatia and colleagues, including lead author and Ph.D. candidate Kevin Lin and postdoctoral fellow Gabriel Kwong, point out that blood clots — clumps of platelets and fibrin proteins — can threaten to choke off blood flow and lead to a wide range of serious and sometimes fatal conditions including atherosclerosis and stroke. Usually, blood clots are a good thing. They form a plug that stops the bleeding after an injury. But sometimes, a clot forms when it really isn’t needed, such as when a person sits too long on a long-distance flight and develops “deep-vein thrombosis.” In that case, a clot forms in the leg, blocking blood flow and causing leg pain. But it also can dislodge and move throughout the body to the heart or even the brain, which is life-threatening. Diagnosing a blood clot, or thrombosis, is tricky, however, and current clinical tests aren’t always reliable. Bhatia’s team wanted to develop a simple and more reliable way to test for these obstructive blood clots.
They describe development and testing of “synthetic biomarkers” — lab-made materials for detecting what is going on in the body. They added small pieces of proteins called peptides onto nanomaterials that are similar to those already approved and used in the clinic. They injected the tiny nanomaterials into mice, which are stand-ins for humans. The peptides got chopped up if a blood clot was actively forming in the mice, and those peptide fragments were detected in a simple urine test. “Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine and may allow applications in point-of-care diagnostics,” the researchers state.
The Latest on: Detecting blood clots
- New PET/CT tracer shows high detection rate for diagnosis of acute venous thromboembolism on February 17, 2019 at 9:29 pm
tracer 18F-GP1 showed excellent image quality and a high detection rate for the diagnosis of acute venous thromboembolism (VTE). Well-tolerated in patients, 18F-GP1 PET/CT also identified blood clots ... […]
- New blood clot discovery could pave way for treating blood diseases on February 16, 2019 at 5:09 pm
In a new study, researchers have discovered new ways in which the body regulates blood clots in a discovery ... a cutting-edge method for detecting free radicals, with blood cell aggregometry ... […]
- Blood clot discovery could lead to development of better treatments for blood diseases on February 15, 2019 at 7:29 pm
Scientists have discovered new ways in which the body regulates blood clots, in a discovery which could one day ... The technique combines electron paramagnetic resonance, a cutting-edge method for de... […]
- Blood clot discovery could pave way for treatment of blood diseases on February 15, 2019 at 6:31 am
Scientists have discovered new ways in which the body regulates blood clots, in a discovery which ... a cutting-edge method for detecting free radicals, with blood cell aggregometry, an ... […]
- Five warning signs of overdiagnosis on February 4, 2019 at 4:10 pm
We’ve had it drummed into us over decades that early detection is key to treating ... more people were diagnosed with these lung blood clots and started on blood thinning drugs. […]
via Google News and Bing News