Scientists have moved closer to developing a universal flu vaccine by using the 2009 pandemic to study why some people seem to resist severe illness.
Researchers at Imperial College London asked volunteers to donate blood samples just as the swine flu pandemic was getting underway and report any symptoms they experienced over the next two flu seasons.
They found that those who avoided severe illness had more CD8 T cells, a type of virus-killing immune cell, in their blood at the start of the pandemic.
They believe a vaccine that stimulates the body to produce more of these cells could be effective at preventing flu viruses, including new strains that cross into humans from birds and pigs, from causing serious disease.
The findings are published in Nature Medicine.
Professor Ajit Lalvani from the National Heart and Lung Institute at Imperial College London, who led the study, said: “New strains of flu are continuously emerging, some of which are deadly, and so the Holy Grail is to create a universal vaccine that would be effective against all strains of flu.”
Today’s flu vaccines make the immune system produce antibodies that recognise structures on the surface of the virus to prevent infection with the most prevalent circulating strains. But they are usually one step behind as they have to be changed each year as new viruses with different surface structures evolve.
Previously, experimental models had suggested that T cells may protect against flu symptoms but until now this idea has not been tested in humans during a pandemic.
Professor Lalvani’s team rapidly recruited 342 staff and students at Imperial to take part in their study in autumn 2009. The volunteers donated blood samples and were given nasal swabs. They were sent emails every three weeks asking them to fill in a survey about their health. If they experienced flu symptoms, they took a nasal swab and sent it back to the lab.
They found that those who fell more severely ill with flu had fewer CD8 T cells in their blood, and those who caught flu but had no symptoms or only mild symptoms had more of these cells.
Professor Lalvani said, “The immune system produces these CD8 T cells in response to usual seasonal flu. Unlike antibodies, they target the core of the virus, which doesn’t change, even in new pandemic strains. The 2009 pandemic provided a unique natural experiment to test whether T cells could recognise, and protect us against, new strains that we haven’t encountered before and to which we lack antibodies.
“Our findings suggest that by making the body produce more of this specific type of CD8 T cell, you can protect people against symptomatic illness. This provides the blueprint for developing a universal flu vaccine.
The Latest Bing News on:
Universal flu vaccine
- New Directors Elected to BiondVax's Board of Directorson March 24, 2020 at 1:08 pm
BiondVax Pharmaceuticals Ltd. (Nasdaq: BVXV), developer of the universal influenza vaccine candidate M-001, announced that all proposed resolutions were approved at the Company's Annual General ...
- A universal flu vaccine in their sightson March 24, 2020 at 2:52 am
The Duke Human Vaccine Institute, emboldened with up to $400 million in federal grants over the next seven years, is playing a key role in the development of a universal flu vaccine. It’s a feat that, ...
- Universal Flu Vaccine Candidate: Promising Results in Efficacy Trialon March 19, 2020 at 2:57 am
Trial results were published March 13 in the journal npj Vaccines. H1N1 influenza virus particles/National Institute of Allergy and Infectious Diseases (NIAID) FLU-v is an example of a “universal” ...
- Versatope Selects Influenza Vaccine Candidate for Clinical Developmenton March 18, 2020 at 5:21 pm
Versatope Therapeutics, Inc., a biotechnology company developing vaccines and therapeutics, announced today the selection of VT-105, a universal influenza vaccine candidate for clinical development. V ...
- Lessons for the Movie Industry from the 1918 Influenza Pandemicon March 17, 2020 at 4:16 pm
Second, Universal’s parent company, Comcast ... arose in the wake of a public-health crisis similar to the one the world faces now: the influenza pandemic of 1918. I’ve been reading “History of the ...
- Open Orphan: Flu vaccine data showcased in peer reviewed articleon March 16, 2020 at 12:41 am
FLU-v has been developed by Imutex, 49%-owned by Open Orphan unit hVIVO, as the first 'universal', broad-spectrum influenza vaccine. The publication of the results in the periodical 'npj Vaccines' ...
- This Isn’t the First Time Progressives Thought Disease Would Make the Case for Universal Health Careon March 13, 2020 at 12:29 pm
Did the 1918–19 influenza epidemic affect that conversation at all ... Because now we’re seeing that the lack of universal health care is deadly, and the right to stay home for a few days and not lose ...
- Universal Resorts in Hollywood and Orlando to Close Amid Coronavirus Pandemicon March 12, 2020 at 11:08 pm
Both Florida and California's governors have declared a state of emergency in order to redirect funds and fight the spread of the virus Universal Studios Hollywood in California and Universal Orlando ...
- Universal Studios Hollywood to Close Through the End of the Month Amid Coronavirus Pandemicon March 12, 2020 at 4:24 pm
Universal Studios Hollywood in California announced it will close amid the coronavirus outbreak in the U.S. The news comes just a few hours after Disneyland made a similar statement. The theme parks ...
- Potential universal flu vaccine shows efficacy in clinical trialon March 12, 2020 at 9:55 am
A new study, published in the Annals of Internal Medicine, has found a potential universal flu vaccine could soon be on the horizon after a candidate demonstrated promise in a small clinical trial.
The Latest Google Headlines on:
Universal flu vaccine
The Latest Bing News on:
- U.S. Influenza Vaccines Market Segmentation, Opportunities, Trends & Future Scope to 2026 | Sanofi Pasteur, Seqirus Vaccines Ltd.on March 24, 2020 at 10:15 pm
U.S. Influenza Vaccines Market Research Report 2020, is mostly driven by the improved taking on of U.S. Influenza ...
- VT professor compares COVID -19 to Spanish Influenza, talks about importance in documentationon March 24, 2020 at 7:04 pm
Tom Ewing is a history professor at Virginia Tech but specifically focuses on pandemics, like the Spanish influenza of 1918.
- Novavax Shares Rally On Flu Vaccine Study Results: What You Need To Knowon March 24, 2020 at 5:11 pm
Novavax, Inc. (NASDAQ: NVAX), which was in the news recently on account of its COVID-19 vaccine development program, is in the spotlight yet again Tuesday. Flu Vaccine Candidate A ...
- Novavax Gets a Big Win for Its Flu Vaccine in Phase 3 Trialon March 24, 2020 at 11:27 am
On Tuesday, vaccine-specialist Novavax (NASDAQ:NVAX) reported positive news from the phase 3 trial for its flu vaccine, NanoFlu: The treatment met both the primary and secondary endpoints of the study ...
- Novavax’s seasonal flu vaccine just got great news. And it’s a big deal.on March 24, 2020 at 7:54 am
In heartbreaking scenes, Georgie continued to see visions of her late husband-to-be as she attended her beloved sister's wedding, with viewers sharing their own emotional reaction.
- A day in the life of a passenger in lockdown aboard a Holland America cruise ship where 42 people have reported feeling 'influenza-like symptoms'on March 24, 2020 at 6:35 am
Passengers on board the Holland America's MS Zaandam have been asked to remain in their state rooms as the ship attempts to sail to Fort Lauderdale.
- Novavax: Influenza Vaccine NanoFlu Meets Primary Goals In Phase 3 Clinical Trialon March 24, 2020 at 3:36 am
In pre-market activity on Nasdaq, Novavax shares were gaining around 37.08 percent at $14.75. In a statement, the company said that NanoFlu, its recombinant quadrivalent seasonal influenza vaccine ...
- The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Viruson March 24, 2020 at 3:07 am
Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and ...
- Pediatric Influenza Treatment Market Dynamics, Comprehensive Analysis, Business Growth, Prospects and Opportunities 2020-2024on March 24, 2020 at 2:09 am
Mar 24, 2020 (The Expresswire) -- "Final Report will add the analysis of the impact of COVID-19 on this industry." Global “Pediatric Influenza ...
- Fact check: Why is the 1918 influenza virus called 'Spanish flu'?on March 23, 2020 at 7:37 am
On March 20, the Facebook page Unbelievable Facts shared a graphic on the origins of the 1918 flu pandemic’s more common name, the “Spanish flu.” According to the post, the pandemic earned the name ...