Researchers identify a novel approach to enhance tissue growth
STUDY FINDINGS OFFER PROMISING NEW DIRECTION FOR ORGAN REGENERATION AND TISSUE REPAIR
Because most human tissues do not regenerate spontaneously, advances in tissue repair and organ regeneration could benefit many patients with a wide variety of medical conditions.
Now a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and Dana-Farber/Boston Children’s Cancer and Blood Disorders Center has identified an entirely new approach to enhance normal tissue growth, a finding that could have widespread therapeutic applications.
Their findings were published on-line this week in the Proceedings of the National Academy of Sciences (PNAS).
Tissue regeneration is a process that is not fully understood, but previous research has demonstrated that endothelial cells lining the insides of small blood vessels play a key role in tissue growth. It is also known that these endothelial cells generate chemical messengers called epoxyeicosatrienoic acids (EETs), which stimulate blood vessel formation in response to tissue injury.
In this new research, first author Dipak Panigrahy, MD, an investigator in BIDMC’s Center for Vascular Biology Research, and his colleagues wanted to find out how EETs might participate in organ and tissue regeneration. To answer this question, they created seven different mouse models. The models focused on liver, kidney and lung regeneration; wound healing; corneal vascularization; and retinal vascularization.
“We used genetic and pharmacologic tools to manipulate EET levels in the animals to show that EETs play a critical role in accelerating tissue growth, providing the first in vivo demonstration that pharmacological modulation of EETs can affect organ regeneration,” explains Panigrahy, an Instructor in Pathology at Harvard Medical School. Administering synthetic EETs spurred tissue growth in the research models; conversely, lowering EET levels – by either manipulating genes or administering drugs – delayed tissue regeneration.
The team also demonstrated that proteins called soluble epoxide hydrolase (sEH) inhibitors, known to elevate EET levels, promoted liver and lung regeneration. (sEH is the main metabolizing enzyme of EETs.)
“Our results offer a mechanistic rationale for evaluating sEH inhibitors as novel therapeutics for a number of human diseases such as hepatic insufficiency after liver damage and diseases characterized by immature lung development, such as bronchopulmonary dysplasia,” says Panigrahy, adding that the use of topical sEH inhibitors on the skin might also be useful for the acceleration of wound healing.
The researchers suspected that EETs were stimulating tissue regeneration by way of blood vessel formation, specifically by producing vascular endothelial growth factor (VEGF) to promote vessel growth. As predicted, when the investigators depleted VEGF in the mice, EETs’ effects on organ regeneration disappeared.
“Discovering EETs’ role could be of critical importance to help control the repair of liver, lungs and kidneys,” says senior author Mark Kieran, MD, PhD, of the Division of Pediatric Oncology at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. “Since diseases of these organs are a major cause of morbidity and mortality in the North American population, the opportunity to modulate the regeneration of healthy tissue could have significant therapeutic implications for many patients.” These findings may also apply to conditions or physical defects that lead to the loss of specialized cells in other organ systems, such as the nervous system and the immune system.
The Latest on: Organ Regeneration
- An Interview with Dr. Kevin Strangeon September 9, 2019 at 8:55 am
Kevin Strange is the CEO and co-founder of Novo Biosciences, a biotechnology company focused on regenerating the heart and other organs. We recently had the opportunity to interview him about MSI-1436 ...
- The Outside Story: Talking ‘Bout Regenerationon September 6, 2019 at 8:36 am
Newts can regenerate legs, jaws, spinal cords, retinas and lenses, even internal organs – in some cases, over and over and over again. A 2011 study found that individual newts could regrow lenses up ...
- New hair follicles can corral skin canceron September 6, 2019 at 4:58 am
The regeneration of hair follicles protects against ... emerges as a paradigm for principles that could be applied to other organs that do not rely on the immune system for the tolerance of ...
- Heart regeneration: Scientists uncloak one of nature's deepest secretson September 5, 2019 at 6:32 am
By contrast, the neonatal mouse heart can efficiently regenerate healthy tissue, allowing the organ to function efficiently afterward. The animals lose the capability after the first week of life ...
- RegeneRx Modifies September Conference Scheduleon September 4, 2019 at 6:14 am
for tissue and organ protection, repair and regeneration. RegeneRx currently has three drug candidates in clinical development for ophthalmic, cardiac and dermal indications, three active ...
- Regenerative Medicine market Analysis Reports Revenue Growth Globally During The Forecast Period 2018-2024on September 3, 2019 at 3:41 am
Sep 03, 2019 (AmericaNewsHour) -- Overview Regenerative medicine is an interdisciplinary field that applies life science and engineering principles for the regeneration or repair of injured/diseased ...
- Interview with Seok-Hwan You of Rokit Healthcare on Bioprintingon September 3, 2019 at 1:00 am
3D biofabrication and the development of patient-specific tissue and organ regeneration therapies are our core capabilities. However, we are also involved in the provision of other healthcare ...
- A strong sibling bond grows closer with live organ transplanton August 31, 2019 at 7:00 am
Ed said he hopes to be back on the air at Fox later this fall, 20 pounds lighter and with a new appreciation for his liver — the only internal organ that can regenerate itself. “When I initially told ...
- Decellularized liver scaffolds promote liver regeneration after partial hepatectomyon August 29, 2019 at 2:09 am
had infiltrated into the scaffold from the native organ, even on day 10, compared to the control without the scaffold. During the regeneration process at 28 days, neovascularization had occurred in ...
- Seeking Solutions to the Organ Donor Shortageon August 27, 2019 at 9:27 pm
Re “How to Fix the Organ Donation Crisis” (editorial ... While there are risks to donors, whose livers regenerate after a portion is removed, it’s important to know that screening them pre-transplant ...
via Google News and Bing News