The fight against antibiotic-resistant superbugs has taken a step forward thanks to a new discovery by scientists at The University of Nottingham.
A multi-disciplinary research team at the University’s Centre for Biomolecular Sciences has uncovered a new way of inhibiting the toxicity and virulence of the notorious superbug, Pseudomonas aeruginosa.
This bacteria produces an armoury of virulence factors and is resistant to many conventional antibiotics. It is almost impossible to eradicate P. aeruginosa from the lungs of people with cystic fibrosis and is therefore a leading cause of death among sufferers. The bug also causes a wide range of infections particularly among hospital patients.
The new discovery concerns the bacterial cells’ ability to ‘talk’ to each other by producing and sensing small chemical signal molecules. This is called ‘quorum sensing’ (QS) and enables a population of individual bacteria to act socially rather than as individuals. QS allows a population of bacteria to assess their numerical strength and make a decision only when the population is ‘quorate’.
The mechanism through which QS signals work is by activating gene expression upon interaction of a QS signal molecule with a receptor protein. In many disease-causing bacteria, QS controls genes which are essential for infection. These genes code for virulence factors such as toxins which cause damage to host tissues and the immune system. Interfering with the QS signalling process blocks bacterial virulence and renders bacteria unable to cause infection. Consequently QS systems are molecular targets for the development of new anti-infective drugs which do not kill bacteria but instead block their ability to cause disease.
The Latest on: Superbugs
Scientists spy on superbugs to see how they outsmart our antibiotics
on May 23, 2019 at 9:00 pm
Scientists have discovered yet another way that single-celled organisms have outsmarted us. The tiny bacteria that live inside our guts have an ingenious way of withstanding the onslaught of ... […]
Opinion: Our frontline defense against ‘superbugs’ is fatally weakened
on May 23, 2019 at 1:31 pm
In Geneva this week, perhaps no other agenda item at the World Health Assembly seems so pressing, so frightening, so potentially global in reach, as antimicrobial resistance. The race is on to prevent ... […]
Write Stuff: ‘Superbugs’, ‘Frog Hollow’ and ‘Artful Dodger’
on May 23, 2019 at 7:51 am
A doctor who is also an author and writers of new novels will give free talks at RJ Julia Booksellers, 768 Boston Post Road, Madison. All events require reservations: 203-245-3959 or rjjulia.com. On ... […]
New Antimicrobials One of the Potential Solutions to Resistant Superbugs - WHO
on May 23, 2019 at 5:36 am
Novel 'first in class' IV antibiotic approved for use in Canada. IVOZFO ™ (fosfomycin for injection) provides a new option for hard to treat infections, including multi-drug resistant superbugs. ... […]
What One Doctor Is Doing To Fight Antibiotic-Resistant 'Superbugs'
on May 22, 2019 at 9:14 pm
A doctor’s story of what it takes to save patients from increasingly deadly pathogens. As drug-resistant bacteria spread, can new genomic science battle back the superbugs? Fleming’s chance discovery ... […]
Brainstorm Health: CRISPR V. Superbugs, Gottlieb to NEA, UniQure Gene Therapy
on May 22, 2019 at 4:08 pm
Hello and happy hump day, readers! Former Food and Drug Administration (FDA) Commissioner Scott Gottlieb already has a new gig. Gottlieb unexpectedly departed from his position as the country’s ... […]
Scientists Modify Viruses With CRISPR To Create New Weapon Against Superbugs
on May 22, 2019 at 2:21 am
Alphonso Evans rolls his wheelchair into a weight machine in the gym at the Charlie Norwood VA Medical Center in Augusta, Ga. "I'm not so much worried about dying from a heart attack or diabetes, ... […]
Fighting Superbugs With Multipronged Pushback
on May 20, 2019 at 10:21 am
Better education, more advanced pharmaceuticals, and stronger cleaning protocols for healthcare facilities are needed to fight superbugs, according to Kamna Giare-Patel, MS, RN, senior director of ... […]
How a school lunch in Tompkins County will help fight "Superbugs"
on May 20, 2019 at 3:35 am
How a school lunch in Tompkins County will help fight "Superbugs" Changes to meat contracts at four Tompkins County schools aims to reduce the use of antibiotics in cattle and fight ... […]
The Death of Antibiotics: We’re Running Out of Effective Drugs to Fight Off an Army of Superbugs
on May 15, 2019 at 4:00 am
In January, Columbia University revealed that four patients at its Irving Medical Center in New York had been sick with an unusual version of E. coli, a common gut bacterium. Although the news largely ... […]
via Google News and Bing News