Scientists have developed an “intelligent knife” that can tell surgeons immediately whether the tissue they are cutting is cancerous or not.
In the first study to test the invention in the operating theatre, the “iKnife” diagnosed tissue samples from 91 patients with 100 per cent accuracy, instantly providing information that normally takes up to half an hour to reveal using laboratory tests.
The findings, by researchers at Imperial College London, are published today in the journal Science Translational Medicine. The study was funded by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, the European Research Council and the Hungarian National Office for Research and Technology.
In cancers involving solid tumours, removal of the cancer in surgery is generally the best hope for treatment. The surgeon normally takes out the tumour with a margin of healthy tissue. However, it is often impossible to tell by sight which tissue is cancerous. One in five breast cancer patients who have surgery require a second operation to fully remove the cancer. In cases of uncertainty, the removed tissue is sent to a lab for examination while the patient remains under general anaesthetic.
The iKnife is based on electrosurgery, a technology invented in the 1920s that is commonly used today. Electrosurgical knives use an electrical current to rapidly heat tissue, cutting through it while minimising blood loss. In doing so, they vaporise the tissue, creating smoke that is normally sucked away by extraction systems.
The inventor of the iKnife, Dr Zoltan Takats of Imperial College London, realised that this smoke would be a rich source of biological information. To create the iKnife, he connected an electrosurgical knife to a mass spectrometer, an analytical instrument used to identify what chemicals are present in a sample. Different types of cell produce thousands of metabolites in different concentrations, so the profile of chemicals in a biological sample can reveal information about the state of that tissue.
In the new study, the researchers first used the iKnife to analyse tissue samples collected from 302 surgery patients, recording the characteristics of thousands of cancerous and non-cancerous tissues, including brain, lung, breast, stomach, colon and liver tumours to create a reference library. The iKnife works by matching its readings during surgery to the reference library to determine what type of tissue is being cut, giving a result in less than three seconds.
The technology was then transferred to the operating theatre to perform real-time analysis during surgery. In all 91 tests, the tissue type identified by the iKnife matched the post-operative diagnosis based on traditional methods.
The Latest Bing News on:
- Former colleague of Celeste Manno who allegedly broke into her home and stabbed her to death in a frenzied knife attack DOESN'T have mental health issues, court hearson November 19, 2020 at 11:19 pm
Lawyers for Luay Sako, 35, - the man charged with the murder of young graduate Celeste Manno, 23, - say he was not on any medication and does not have a history of mental illness.
- JoJo's Bizarre Adventure: 5 Of Dio's Greatest Strengths (& His 5 Worst Weaknesses)on November 19, 2020 at 11:59 am
Dio Brando would not have been an iconic JoJo's villain without his biggest strengths & weaknesses. Dio Brando is the most iconic antagonist of the JoJo's Bizarre Adventure universe and a threat whose ...
- Thirteen arrests in a week in knife crime crackdownon November 19, 2020 at 7:00 am
Thirteen people across Norfolk and Suffolk were arrested in the space of a week as part of a nationwide crackdown on knife crime.
- Nine arrests as police target knife crime and county lines activityon November 19, 2020 at 6:48 am
Nine people were arrested in Suffolk last week as part of national operation targeting knife crime and county lines gang activity.
- Man charged with murder of young graduate Celeste Manno, 23, after she was attacked in her bedon November 19, 2020 at 2:44 am
A man has been charged with murdering young graduate Celeste Manno. Luay Sako, 35, handed himself in to local police hours after Ms Manno's death and was taken to hospital under police guard.
- Reading park knife attack: Who were the victims?on November 11, 2020 at 9:34 am
The three friends killed in the Reading park knife attack were described as kind ... “James was a wonderful man. He was beautiful, intelligent, honest and fun. “He was the best son, brother, uncle and ...
- Reading park knife attack: Who were the victims?on November 11, 2020 at 9:28 am
The three friends killed in the Reading park knife attack were described as kind ... He was beautiful, intelligent, honest and fun. “He was the best son, brother, uncle and partner you could ...
- Honor announces two Electric Shavers, AI car Holder, and a Humidifier in Chinaon November 3, 2020 at 6:52 am
It also has a floating knife net, a floating comfort zone ... Alongside the shavers, Honor also unveiled a new Intelligent Voice Car Holder in partnership with DDPAI. The highlight is the voice ...
- Why Krav Maga is not just self-defence, but intelligent and pragmatic self-protectionon October 28, 2020 at 10:18 am
Krav Maga teaches you an array of self-defence moves — be it a knife attack, a blow (which can come from any side), a verbal threat, a choke-hold (which can get you off-guard from any corner ...
The Latest Google Headlines on:
The Latest Bing News on:
Fix the internet
- Consumer Reports tests WiFi range extenders to fix spotty internet connectionon November 27, 2020 at 5:57 pm
The experts at Consumer Reports recently tested several WiFi range extenders to potentially fix a spotty internet connection or dead zones.
- Amazon's $599 router system isn't cheap, but it helps fix your bad Wi-Fion November 27, 2020 at 4:44 pm
You might want to try mesh networking if you know you pay for fast internet but feel like your home Wi-Fi is slow in some rooms.
- NHL jerseys: An honest review of every team's current uniforms, from the classics to teams in need of a changeon November 27, 2020 at 2:09 pm
Following the rankings and grades for those jerseys, I figured it would be an appropriate time to do a general check-in with the state of every team's uniforms while proposing some ways to make them ...
- Drupal issues emergency fix for critical bug with known exploitson November 27, 2020 at 8:31 am
Drupal has released emergency security updates to address a critical vulnerability with known exploits that could allow for arbitrary PHP code execution on some CMS versions.
- Engines Keep Failing as the Subaru BRZ/Scion FR-S Valve Spring Recall Debacle Drags Onon November 27, 2020 at 6:24 am
It's been over a year since a class-action lawsuit was filed. Meanwhile, more engines are failing after a recall service.
- Autodoorstep - Get High Quality Professional Cleaning, Maid,Repair & Home Services In Dubaion November 26, 2020 at 4:19 pm
Therefore to help the residents of Dubai and to save them from the hassles of cleaning and managing things in their homes, office, and workplaces the company is offering various kinds of cleaning ...
- Alibaba CEO says regulations for internet firms ‘necessary’on November 23, 2020 at 11:00 am
HONG KONG (AP) — The chairman and CEO of e-commerce giant Alibaba Group praised Chinese regulators Monday in a possible attempt to repair ties after the stock market debut of its former ...
- The pandemic uncovered south Phoenix's digital divide. Here's how the city wants to forge a permanent fixon November 20, 2020 at 8:43 am
Imelda Hartley's children struggled with remote school in a home with slow internet. Phoenix provided a stopgap as it looks to fix the digital divide.
- Sony has a fix for the PS5 'Queued for Download' bugon November 20, 2020 at 6:59 am
There's now a fix for a particularly inconvenient bug that's been happening on the PS5. According to the Ask PlayStation Twitter, players now have the ability to help get rid of a bug that resulted in ...
- Working from home with weak internet? There's a device to fix thaton November 19, 2020 at 2:36 pm
Doing school, work or relaxing at home can put a strain on your internet, but mesh devices can boost your Wi-Fi. And 2020 brings a new twist: Wi-Fi 6.