Super resolution microscopy is a technique that can see beyond the diffraction of light and provides unprecedented views of cells and their interior structures and organelles.
An EPFL team has developed a technique that can perform both 3D super resolution microscopy and fast 3D phase imaging in a single instrument.
This unique 4D microscope combines a sensitivity and high time resolution of phase imaging with the specifically and high spatial resolution of fluorescence microscopy. This allows the direct visualization and Analysis of subcellular structures in living cells without labeling.
These technical advances enable high-resolution visualization of the formation of pathological alpha-synuclein aggregates in hippocampal neurons. It is hoped that it will become a regular workhorse for neuroscience and biology.
Learn more: Super-resolution microscopy in both space and time
The Latest on: Super resolution microscopy
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The Latest on: Super resolution microscopy
- Advancing high-resolution ultrasound imaging with deep learningon April 22, 2024 at 11:38 am
Researchers at the Beckman Institute for Advanced Science and Technology have developed a new technique to make ultrasound localization microscopy, an emerging diagnostic tool used for high-resolution ...
- New super-resolution microscopy approach visualizes internal cell structures and clusters via selective plane activationon April 22, 2024 at 9:08 am
To study living organisms at ever smaller length scales, scientists must devise new techniques to overcome the so-called diffraction limit. This is the intrinsic limitation on a microscope's ability ...
- Improved mid-infrared nanoscopy enables 30 times clearer view of the insides of bacteriaon April 17, 2024 at 8:03 am
A team at the University of Tokyo have constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is ...
- Advanced microscopy technique offers a new look inside cellson April 11, 2024 at 7:34 am
Imagine tuning into a football game, but all of the players are invisible except for the two quarterbacks. Without being able to see the orchestrated movements of the full teams, this would be a very ...
- Super-Resolution Microscopy Can Be Super-Accessibleon April 9, 2024 at 9:26 am
To bring single-molecule localization microscopy to everyday researchers, laboratories can upgrade existing systems or deploy all-new platforms.
- Artificial intelligence enhances super-resolution microscopyon April 2, 2024 at 4:59 pm
Computational methods and algorithmic data processing are an important aspect of super-resolution microscopy, but a new approach to the task could offer a route to enhanced imaging. Generative AI is ...
- Artificial intelligence boosts super-resolution microscopyon March 27, 2024 at 5:01 pm
A fluorescence micrograph taken from the open BioSR super-resolution microscopy dataset (above and left of the dashed line) is compared to the same picture that has been reconstructed by the CVDM ...
- Super-Resolution Microscopy: Capturing the Nano-Worldon February 28, 2024 at 8:00 am
which makes imaging samples smaller than 200 nm almost impossible with conventional microscopy. Super resolution microscopy breaks through the diffraction limit, allowing scientists and researchers to ...
- Microscopy method overcomes the traditional resolution limit for the fast co-tracking of moleculeson February 14, 2024 at 7:43 am
This resolution limit has traditionally been overcome in super-resolution microscopy methods by making the dyes blink and turning their fluorescence on and off. This temporally separates their ...
- Light Microscopyon August 17, 2023 at 12:37 am
Scientists can now use super-resolution microscopy to directly observe living subcellular structures and activities. In this piece, we explore the basics of three popular super-resolution techniques.
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