A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
Scientists are not just excited about this recently discovered technique because it can snip and edit DNA with precision. It can also do the job more easily and cheaply than other gene-editing methods, making possible research that has historically been difficult, experts say.
Now some of the biologists who unlocked this tool, derived from the immune system of bacteria, are forming companies around it. Although this molecular system, known as Crispr, is not fully understood, researchers believe it can be harnessed to create therapies for intractable genetic diseases.
“In principle, this is a technology that could enable correction of genetic mutations that would otherwise lead to disease,” said Doudna, a professor of chemistry and biochemistry and molecular biology, in a telephone interview. She was among several experts who spoke at a UC Berkeley conference on the subject last month.
Ethical concerns
But because the method is in its infancy and has little precedent with the agencies that regulate medicines, it will almost certainly be a long time before a Crispr-based therapy makes it to market.
Its potential risks also concern some bioethicists.
The Latest on: Editing DNA
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The Latest on: Editing DNA
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This launch marks the successful precision editing of the human genome using customizable gene editors crafted entirely through AI.
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Regeneron Pharmaceuticals and Mammoth Biosciences will collaborate to research, develop and commercialize gene editing therapies for multiple diseases, the companies said on Thursday.
- Regeneron, Mammoth Launch In Vivo CRISPR Gene Editing Collaborationon April 25, 2024 at 4:00 am
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Both chemical and enzymatic synthesis companies need to continue working to overcome their respective hurdles.
- AI-designed gene editing tools successfully modify human DNAon April 24, 2024 at 5:51 am
Medically, AI is helping us with everything from identifying abnormal heart rhythms before they happen to spotting skin cancer. But do we really need it to get involved with our genome? Protein-design ...
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Genome editing is the process that allows scientists to change an organism’s DNA, including changing or cutting out sections of genetic code. Scientists adapted the CRISPR-Cas9 system, the most common ...
- Profluent combines LLMs and CRISPR for open-source AI gene editing projecton April 23, 2024 at 11:00 am
Profluent has staked a claim at the intersection of some of the buzziest terms in biopharma. | Profluent has staked a claim at the intersection of some of the buzziest terms in biopharma. The protein ...
- Startup Uses AI to Edit Human DNAon April 23, 2024 at 7:34 am
A team of resaerchers at a Berkeley-based startup called Profulent claim to have used generative AI technologies to edit human DNA. As the New York Times reports, the startup fed huge amounts of ...
- Generative A.I. Arrives in the Gene Editing World of CRISPRon April 22, 2024 at 1:48 pm
Much as ChatGPT generates poetry, a new A.I. system devises blueprints for microscopic mechanisms that can edit your DNA.
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