Biofilms — microbial communities that form slimy layers on surfaces — are difficult to treat and remove, often because the microbes release molecules that block the entry of antibiotics and other therapies. Now, researchers reporting in ACS Applied Materials & Interfaces have made magnetically propelled microbots derived from tea buds, which they call “T-Budbots,” that can dislodge biofilms, release an antibiotic to kill bacteria, and clean away the debris.
Many hospital-acquired infections involve bacterial biofilms that form on catheters, joint prostheses, pacemakers and other implanted devices. These microbial communities, which are often resistant to antibiotics, can slow healing and cause serious medical complications. Current treatment includes repeated high doses of antibiotics, which can have side effects, or in some cases, surgical replacement of the infected device, which is painful and costly. Dipankar Bandyopadhyay and colleagues wanted to develop biocompatible microbots that could be controlled with magnets to destroy biofilms and then scrub away the mess. The team chose Camellia sinensis tea buds as the raw material for their microbots because the buds are porous, non-toxic, inexpensive and biodegradable. Tea buds also contain polyphenols, which have antimicrobial properties.
The researchers ground some tea buds and isolated porous microparticles. Then, they coated the microparticles’ surfaces with magnetite nanoparticles so that they could be controlled by a magnet. Finally, the antibiotic ciprofloxacin was embedded within the porous structures. The researchers showed that the T-Budbots released the antibiotic primarily under acidic conditions, which occur in bacterial infections. The team then added the T-Budbots to bacterial biofilms in dishes and magnetically steered them. The microbots penetrated the biofilm, killed the bacteria and cleaned the debris away, leaving a clear path in their wake. Degraded remnants of the biofilm adhered to the microbots’ surfaces. The researchers note that this was a proof-of-concept study, and further optimization is needed before the T-Budbots could be deployed to destroy biofilms in the human body.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Manufacturing research partnership to tackle harmful biofilmson October 5, 2020 at 3:45 pm
Over $5 million will be co-invested in the R&D of therapeutic treatments for biofilm mediated infection with industry manufacturer Whiteley Corporation.
- Tea bud "robots" used to kill and clear bacteriaon September 28, 2020 at 12:42 pm
When harmful bacteria colonize the surface of items such as medical implants, they form slimy antibiotic-resistant coatings known as biofilms. Scientists have devised a new way of removing such ...
- Animalcare Group PLC - Animalcare and Kane Biotech to target biofilmson September 27, 2020 at 11:09 pm
Marc Edwards, President and Chief Executive Officer of Kane Biotech said: "We are very excited to partner with Animalcare to establish an animal health company dedicated to treating biofilms ...
- Eliminating Biofilms with Green Tea-Derived Nanobotson September 25, 2020 at 9:32 pm
Bacteria, including bacterial pathogens, can also form tough communities called biofilms. As bacteria multiply and spread over a surface, the coating of microbes that is generated is difficult to ...
- Magnetic 'T-Budbots' made from tea plants kill and clean biofilms (video)on September 23, 2020 at 12:21 pm
Biofilms -- microbial communities that form slimy layers on surfaces -- are difficult to treat and remove, often because the microbes release molecules that block the entry of antibiotics and other ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Transparent fibre sensors ‘smell, hear and touch’on October 1, 2020 at 3:42 am
In addition to the respiratory sensors, the printing technique can also be used to make biocompatible fibres of a similar dimension to biological cells, which enables them to guide cell movements and ...
- Watch how tea and magnets combine to combat biofilmson September 30, 2020 at 8:19 am
Porous microparticles derived from Camellia sinensis tea buds were coated with magnetite nanoparticles to enable manipulation by magnet. The antibiotic ciprofloxacin was also embedded within the ...
- 10 Nanotech Breakthroughs You Should Know About (Updated)on September 27, 2020 at 5:00 pm
They have also developed a biocompatible riboflavin-containing photoinitiator ... The robots used in the procedure has a diameter of 285 µm. The magnetic microbots are powered using external magnetic ...
- Magnetic 'T-Budbots' made from tea plants kill and clean biofilms (w/video)on September 23, 2020 at 9:34 am
Dipankar Bandyopadhyay and colleagues wanted to develop biocompatible microbots that could be controlled with magnets to destroy biofilms and then scrub away the mess. The team chose Camellia sinensis ...
- Magnetic 'T-Budbots' made from tea plants kill and clean biofilmson September 23, 2020 at 9:01 am
Thank you for taking your time to send in your valued opinion to Science X editors. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. Your ...