via Imperial College London
Baloxavir treatment reduced transmission of the flu virus from infected ferrets to healthy ferrets, suggesting that the antiviral drug could contribute to the early control of influenza outbreaks by limiting community-based viral spread, according to a study published April 15 in the open-access journal PLOS Pathogens by Aeron Hurt of F. Hoffmann-La Roche Ltd and Wendy Barclay of Imperial College London, and colleagues. As noted by the authors, this is the first evidence that the rapid reduction in infectious viral particles associated with baloxavir treatment translates into a reduced risk of transmitting influenza to exposed contacts.
Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine for a novel pandemic virus manufactured using current technology will not be available fast enough to mitigate the effect of the first pandemic wave. Antivirals can be effective against many different influenza viruses, but have not been used extensively for outbreak control. A recently licensed antiviral drug called baloxavir has been shown to reduce the amount of virus particles produced by infected people more effectively than the widely used drug oseltamivir. In the new study, the researchers tested whether baloxavir treatment might also interrupt onward virus transmission.
They found that baloxavir treatment reduced infectious viral shedding in the upper respiratory tract of ferrets infected with A(H1N1)pdm09 influenza viruses compared to placebo, and reduced the frequency of transmission, even when treatment was delayed until two days after infection. By contrast, oseltamivir treatment did not substantially affect viral shedding or transmission compared to placebo. Importantly, the researchers did not detect the emergence of baloxavir-resistant variants in the animals. The results support the idea that antivirals which decrease viral shedding could also reduce influenza transmission in the community. According to the authors, such an effect has the potential to dramatically change how we manage influenza outbreaks, including pandemic influenza.
The authors add, “Our study shows that baloxavir can have a dual effect in influenza: a single dose reduces the symptoms and reduces the risk of passing it on to others as well”.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Susceptibility of Influenza A, B, C, and D Viruses to Baloxaviron October 2, 2020 at 5:00 pm
A/Illinois/08/2018 (H1N1)pdm09 PA-I38 2.12 – 1.75 ± 0.59 A/Illinois/37/2018 (H1N1)pdm09 PA-I38L 14.96 (7-fold)** – 13.09 ± 3.56 (8-fold)** *Both assays were conducted by using MDCK-SIAT1 cells.
- Health officials urge flu shots, warning of "twindemic" with COVID-19on October 1, 2020 at 12:08 pm
Americans need to prioritize getting their influenza vaccine now, public health officials warned Thursday. Why it matters: The seasonal flu combined with the coronavirus pandemic could lead to a ...
- US Health Officials Urge Influenza and Pneumococcal Vaccination Amid COVID-19 Pandemicon October 1, 2020 at 10:00 am
Four licensed influenza antiviral drugs are recommended for use in the US this flu season: oral oseltamivir, inhaled zanamivir, intravenous peramivir, or oral baloxavir. About the National ...
- US Health Officials Urge Influenza and Pneumococcal Vaccination Amid COVID-19 Pandemicon October 1, 2020 at 6:38 am
Four licensed influenza antiviral drugs are recommended for use in the US this flu season: oral oseltamivir, inhaled zanamivir, intravenous peramivir, or oral baloxavir. About the National Foundation ...
- North America Influenza Treatment Markets, 2019-2020 & 2030 - Focus on Oseltamivir Phosphate, Baloxavir Marboxil, Peramivir, Zanamivir & Other Drugson September 23, 2020 at 5:10 pm
Dublin, Sept. 23, 2020 (GLOBE NEWSWIRE) -- The "North America Influenza Treatment Market 2020-2030 by Product Type, Influenza Type, Administration Route, Distribution Channel, and Country: Trend ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
Controlling influenza outbreaks
- Coronavirus live news: Trump aide Stephen Miller tests positive as White House outbreak spreadson October 7, 2020 at 12:30 am
Biden says debate shouldn’t go ahead if Trump still positive; Facebook and Twitter take action against Trump for suggesting Covid-19 just like flu ...
- Flu Vaccine Dubai: How safe is it for pregnant women and children?on October 7, 2020 at 12:02 am
Now that we’re in flu season in the UAE, should you give your child the vaccine? As the world tackles a new deadly virus, an old one rears its ugly head – seasonal flu, caused by the influenza virus, ...
- University of Washington and Greek Row struggle to contain COVID-19 outbreakon October 6, 2020 at 6:18 pm
The university contends its options are limited because the Greek system is off-campus, but fraternities and sororities could lose university recognition if there are ongoing compliance issues.
- COVID-19 reports look at impact of mitigation measures in Arizona; outbreak during family gatheringon October 6, 2020 at 2:41 pm
COVID-19 cases in Arizona fell 75% between July 13 and Aug. 7 after sustained community mitigation measures that promoted social distancing, required or encouraged mask wearing, limited large ...
- 'Morally reprehensible': Doctors react to Trump's tweet comparing Covid-19 to fluon October 6, 2020 at 12:27 pm
"The notion of just learning to live with it is not an acceptable policy or strategy, in my opinion," one expert told NBC News.