A test to detect opioid drugs in exhaled breath has been developed by engineers and physicians at the University of California, Davis. A breath test could be useful in caring for chronic pain patients as well as for checking for illegal drug use.
“There are a few ways we think this could impact society,” said Professor Cristina Davis, chair of the Department of Mechanical and Aerospace Engineering at UC Davis, who led the research along with Professor Michael Schivo from the UC Davis Medical Center. The work is described in a paper published in the Journal of Breath Research Oct. 3.
Doctors and nurses treating chronic pain may need to monitor patients to make sure they are taking their drugs correctly, that their prescribed drugs are being metabolized properly and that they are not taking additional medications. Blood tests are the gold standard: a reliable, noninvasive test would be a useful alternative.
Collecting droplets from breath
For the test developed by postdoctoral researcher Eva Borras, Davis and colleagues, subjects breathe normally into a specialized collection device. Droplets in breath condense and are stored in a freezer until testing. Davis’ lab uses mass spectrometry to identify compounds in the samples.
The researchers tested the technique in a small group of patients receiving infusions of pain medications including morphine and hydromorphone, or oral doses of oxycodone, at the UC Davis Medical Center. They were therefore able to compare opioid metabolites in breath with both blood samples and the doses given to patients.
“We can see both the original drug and metabolites in exhaled breath,” Davis said.
Fully validating the breath test will require more data from larger groups of patients, she said. Davis’ laboratory is working toward real-time, bedside testing.
Other authors on the paper include graduate student Andy Cheng, UC Davis forensic science program; Ted Wun, Department of Internal Medicine; Kristen Reese and Matthias Frank, Lawrence Livermore National Laboratory; and Michael Schivo, UC Davis School of Medicine and VA Northern California Health System.
Davis’ laboratory is working on a variety of applications for detecting small amounts of chemicals, especially in air and exhaled breath. Other projects include diagnosing influenza in people and citrus greening disease in fruit trees.
Learn more: A Breath Test for Opioids
The Latest on: Opioid drug test
via Google News
The Latest on: Opioid drug test
- Millennium Health Identifies National Fentanyl Analog Positivity Which May Increase Risk of Overdose Deathon October 7, 2020 at 7:00 am
A study conducted by Millennium Health and published in Drug and Alcohol Dependence highlights the role real-time urine drug test results ...
- Empty Promises and Preventable Deaths: Trump’s Bungled Response to Opioids Was a Test Run for COVIDon October 6, 2020 at 3:03 am
In fact, his unfounded promises bear a chilling resemblance to his claims about another health crisis: the opioid epidemic. “The number of drug users and the addicted will start to tumble downward ...
- Licensed to Pill: Big opioid prescriber indicted on federal chargeson October 2, 2020 at 11:29 pm
Officials have known about a top opioid prescriber for at least five years. This week the Tennessee and Alabama doctor was federally indicted for illegally distributing opioids, kickbacks and more.
- Trump tests positive for coronaviruson October 2, 2020 at 10:00 am
President Donald Trump is in quarantine at the White House after testing positive for coronavirus, a revelation that could upend his presidency an ...
- Songbirds sing, like humans flock, for opioid rewardon October 2, 2020 at 7:15 am
What do songbirds and humans have in common? We crave social interaction, and the chemical rewards that flood our brain when we get it.
- Why Is Amazon Tracking Opioid Use All Over the United States?on October 2, 2020 at 6:12 am
Experts say Amazon could be tracking opioid usage to determine where to open warehouses, monitor for package theft, or simply because it loves data.
- Trump’s drug czar appears in Brewer after testing negative for COVID-19on October 2, 2020 at 5:26 am
Jim Carroll said his team is working on making sure that naloxone is widely available and that treatment centers across the country are deemed essential.
- RICO Claims Trimmed In SF Opioid Caseon October 1, 2020 at 3:54 pm
A California federal judge on Wednesday trimmed federal racketeering claims against drug companies in the city of San Francisco's suit over the opioid crisis, finding that city property damage caused ...
- The Effect of State Legislation on Opioid Prescriptions Following Arthroscopic Rotator Cuff Repairon October 1, 2020 at 1:16 pm
New Jersey State Law, P.L. 2017 Chapter 28 22, C.24:21–15.2, passed in February 2017, is the most restrictive opioid legislation passed thus far in the United States. This study evaluated the effects ...
- Historic nationwide investigation, with Texas ties, uncovers more than $6B in healthcare fraud, opioid abuseon September 30, 2020 at 7:32 pm
The U.S. Department of Justice announced a historic nationwide enforcement takedown Wednesday involving 345 charged defended across 51 federal districts, according to a press release.
via Bing News