Stem cells hold the key to wound healing, as they develop into specialised cell types throughout the body – including in teeth.
Now an international team of researchers has found a mechanism that could offer a potential novel solution to tooth repair.
Published today in Nature Communications, the study showed that a gene called Dlk1 enhances stem cell activation and tissue regeneration in tooth healing.
The work was led by Dr Bing Hu from the University of Plymouth’s Peninsula Dental School, with collaboration from researchers worldwide*.
The science behind the discovery
Dr Hu and his team discovered a new population of mesenchymal stem cells (the stem cells that make up skeletal tissue such as muscle and bone) in a continuously growing mouse incisor model. They showed that these cells contribute to the formation of tooth dentin, the hard tissue that covers the main body of a tooth.
Importantly, the work showed that when these stem cells are activated, they then send signals back to the mother cells of the tissue to control the number of cells produced, through a molecular gene called Dlk1. This paper is the first to show that Dlk1 is vital for this process to work.
In the same report, the researchers also proved that Dlk1 can enhance stem cell activation and tissue regeneration in a tooth wound healing model. This mechanism could provide a novel solution for tooth reparation, dealing with problems such as tooth decay and crumbling (known as caries) and trauma treatment.
Further studies need to take place to validate the findings for clinical applications, in order to ascertain the appropriate treatment duration and dose, but these early steps in an animal model are exciting, as Dr Hu explains.
What the authors say
Dr Hu, who is also part of the University’s Institute of Translational and Stratified Medicine (ITSMed), said:
“Stem cells are so important, as, in the future, they could be used by laboratories to regenerate tissues that have been damaged or lost due to disease – so it’s vital to understand how they work. By uncovering both the new stem cells that make the main body of a tooth and establishing their vital use of Dlk1 in regenerating the tissue, we have taken major steps in understanding stem cell regeneration.
“The work has taken place in lab models at this stage, and further work needs to be done before we can bring them in to human use. But it’s a really big breakthrough in regenerative medicine that could have huge implications for patients in future.”
Professor Christopher Tredwin, Head of Peninsula Dental School and co-author of the paper, said:
“We are highly excited by the recent progresses in Dr Bing Hu’s group. This new work, together with a recent high-impact paper published in The EMBO Journal (doi: 10.15252/embj.201899845), which is about another type of stem cells in the tooth: epithelial stem cells, puts Plymouth at the front of the world’s dental and craniofacial stem cell research and regenerative medicine. We expect those researchers will soon provide dental patients better time and cost-effective solutions to serious tooth problems – from trauma to caries.”
The Latest on: Self-repairing teeth
via Google News
The Latest on: Self-repairing teeth
- Smart material made from squid ring teeth a potential plastic alternativeon March 3, 2019 at 9:00 pm
A newly-discovered material made from squid teeth could one day replace man-made fibres like ... as well as paving the way for new possibilities such as self-repairing safety clothing, or garments ...
- Squid teeth could help make bioplastics and self-repairing clotheson February 21, 2019 at 2:00 am
To seize prey, squid rely on a battery of tough, serrated suckers at the end of their tentacles known as squid ring teeth (SRT). Now, researchers are finding that a protein in SRTs can be turned into ...
- The first predators and their self-repairing teethon September 24, 2018 at 5:05 am
The earliest predators appeared on Earth 480 million years ago—and they even had teeth capable of repairing themselves. A team of palaeontologists led by Bryan Shirley and Madleen Grohganz from the ...
- The first predators and their self-repairing teethon September 23, 2018 at 6:55 am
The earliest predators appeared on Earth 480 million years ago -- and they even had teeth which were capable of repairing themselves. A team of palaeontologists have been able to discover more about ...
- Stretchy, self-repairing circuits a possibility with new materialon May 22, 2018 at 9:15 am
Previously, researchers have taken inspiration from the natural properties of squid teeth to create self-repairing clothes, and from other living tissue to create self-repairing plastic. Now, a team ...
- Instead of Filling Cavities, Dentists May Soon Regenerate Teethon February 1, 2018 at 3:48 am
For dentists, a cavity is a conundrum—in order to save the tooth they must further damage it. Currently, the primary way to treat a cavity is to excavate the decay and the surrounding area before ...
- Self-Repairing Squid Teeth Clothes Will Be Trendyon August 22, 2016 at 8:56 am
Researchers at Penn State University have concocted a self-repairing material that could reduce the fashion and textile industries’ waste production, and the secret ingredient may not be what you ...
via Bing News