Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process
Damaged peripheral nerves can regenerate after an injury, for example, following a forearm fracture. Axons, the long projections of neurons that transmit stimuli or signals to other cells, are affected in the case of injury and need to regrow to recover their function. The research team led by Prof. Claire Jacob at Johannes Gutenberg University Mainz (JGU) and at the Swiss University of Fribourg investigated the details of this repair process and have demonstrated that the same mechanism could be activated in cells of the central nervous system – after a spinal cord injury, for instance. Their results have been published in the renowned journal Cell Reports.
“An injury in the peripheral nervous system quickly triggers the activation of a fascinating repair process that allows the injured nerve to regenerate and regain its function. There is no such repair process in the central nervous system, thus injuries often lead to permanent damage such as paraplegia,” explains Claire Jacob, Head of Cellular Neurobiology at JGU. Strategies to improve axon regeneration in the central nervous system must therefore be developed to enable healing.
Myelin-forming cells are key to the axon regeneration process. Many axons are ensheathed by myelin, which serves as a protective layer while also enabling fast and efficient signal transmission. “Myelin is extremely important for the function of the entire nervous system, however it also hinders the repair process in case of an injury,” adds Claire Jacob. Myelin is produced by Schwann cells in the peripheral nervous system and by oligodendrocytes in the central nervous system; this difference has a major impact on axon regeneration, because Schwann cells and oligodendrocytes respond very differently to axonal injury.
Schwann cells can do everything – they break down myelin and damaged axons
When axons of the peripheral nervous system are injured, Schwann cells rapidly induce the disintegration of the cut-out axonal segments into small fragments, which can then be digested by Schwann cells themselves or later by macrophages. This elimination of axonal debris is one of the first and critical steps of the repair process. “Schwann cells can do everything. We discovered that they not only digest myelin following injury, but they also induce the disintegration of the long axon segments that are separated from their cell bodies due to the injury,” points out Claire Jacob. In order to do that, Schwann cells form small spheres made of a protein called actin; these actin spheres exert pressure on the isolated axon segments until their disintegration into small pieces. This targeted degradation of cell debris is essential to enable the healthy part of the axon that remained attached to the neuron cell body to grow back, connect to its former target and thereby regain full functionality.
Severed axons transmit signals to Schwann cells
Of particular interest, the Jacob team found that severed axonal segments send a signal to Schwann cells that prompts them to start the actin sphere formation and axon disintegration process, an impressive and precisely coordinated form of interaction between the two cell types. If this mechanism is disrupted, axonal disintegration is slowed down and axonal fragments impair the regeneration of the affected nerve.
Manipulated oligodendrocytes can also generate actin structures
Claire Jacob’s team went on to study the central nervous system and the behavior of oligodendrocytes. “After an injury, oligodendrocytes either die or remain apparently unresponsive,” says Claire Jacob. Oligodendrocytes are not (normally) able, like Schwann cells, to form actin spheres and thus break down axon segments. One reason for this is that, unlike Schwann cells, they do not express VEGFR1, the receptor that triggers the production of actin spheres in Schwann cells. In the next step, the research team induced the expression of VEGFR1 in oligodendrocytes. This allowed oligodendrocytes to produce actin structures and disintegrate severed axonal fragments; this is an essential step to promote the regeneration of neurons in the central nervous system.
The team is currently working at identifying the molecular processes that trigger the removal of myelin at the site of injury in the central nervous system. In addition to the disposal of axonal debris, myelin removal is a second prerequisite necessary for the complete regeneration of neurons. “We have discovered a pathway that accelerates myelin degradation in the peripheral nervous system and are now trying to determine whether this can also trigger myelin removal in the central nervous system,” adds Claire Jacob, describing the results of on-going research in her lab.
The Latest on: Self-repair in the central nervous system
via Google News
The Latest on: Self-repair in the central nervous system
- Neuronal Acetylcholine Receptor Subunit Alpha 7 Pipeline Review, H2 2019 - Therapy Areas Covered Such as Central Nervous System, Cardiovascular, Immunon October 9, 2019 at 3:42 am
Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively. Report covers products from therapy areas Central Nervous System, Cardiovascular, Immunology, Metabolic ...
- MC10, Inc. Announces Collaboration with University of Rochester: Development Novel Digital Biomarkers for Central Nervous System Diseaseson October 2, 2019 at 5:41 pm
MC10, Inc., creators of the innovative wearable device BioStamp nPoint, and the University of Rochester announced today a collaboration on advancing methods of assessing Central Nervous System (CNS) ...
- Central Nervous System Biomarkers Market Latest In-Depth Report Segment by Manufacturers, Type, Applications and Dynamicson September 27, 2019 at 3:22 am
Sep 27, 2019 (Profound via COMTEX) -- A recent report provides crucial insights along with application based and forecast information in the Global Central Nervous System Biomarkers Market. The report ...
- Parasympathetic Nervous Systemon September 16, 2019 at 10:28 am
arising from the spinal nerves of the central nervous system. Axons of this system are typically quite long and extend into ganglia in the rest of the body. These ganglia are typically located in or ...
- Nanocapsule reaches cancer that has spread to central nervous system in miceon August 14, 2019 at 1:55 pm
Cancer that has spread to the central nervous system is notoriously difficult to treat. Now, UCLA researchers have developed a drug delivery system that breaks through the blood-brain barrier in order ...
- First step to induce self-repair in the central nervous systemon July 11, 2019 at 11:24 am
Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process. Damaged peripheral nerves can regenerate ...
- First step to induce self-repair in the central nervous systemon July 11, 2019 at 5:35 am
Claire Jacob at Johannes Gutenberg University Mainz (JGU) and at the Swiss University of Fribourg investigated the details of this repair process and have demonstrated that the same mechanism could be ...
- Research into worms’ central nervous system could bring insight into mental health disorderson July 6, 2019 at 11:09 am
Scientists have created the most complete network ever of a central nervous system, a team of neurobiologists reported in the journal Nature. The researchers traced every neuron in small worms to ...
- Microglia, cells thought restricted to central nervous system, are redefined in new studyon April 4, 2019 at 11:41 am
Inside the central nervous system (CNS), a region that includes the brain and spinal cord, it is the job of certain cells, called microglia, to clean up that cellular debris. Microglia have ...
- Novel Method to Classify Tumors in the Central Nervous Systemon March 19, 2018 at 7:38 am
A new method to classify tumors in the central nervous system (the brain and the spinal cord) based on DNA- methylation has been developed by recent research at the Heidelberg University Hospital and ...
via Bing News