Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.
The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.
“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”
Terskikh studies a type of cell called dermal papilla. Residing inside the hair follicle, these cells control hair growth, including hair thickness, length and growth cycle. In 2015, Terskikh successfully grew hair underneath mouse skin (subcutaneous) by creating dermal papilla derived from human pluripotent stem cells—a tantalizing but uncontrolled process that required further refinement.
The approach detailed in the ISSCR presentation, which was delivered by lead researcher Antonella Pinto, Ph.D., a postdoctoral researcher in the Terskikh lab, features a 3D biodegradable scaffold made from the same material as dissolvable stitches. The scaffold controls the direction of hair growth and helps the stem cells integrate into the skin, a naturally tough barrier. The current protocol relies on mouse epithelial cells combined with human dermal papilla cells. The experiments were conducted in immunodeficient nude mice, which lack body hair.
The derivation of the epithelial part of a hair follicle from human iPSCs is currently underway in the Terskikh lab. Combined human iPSC-derived epithelial and dermal papilla cells will enable the generation of entirely human hair follicles, ready for allogenic transplantation in humans. Distinct from any other approaches to hair follicle regeneration, human iPSCs provide an unlimited supply of cells and can be derived from a simple blood draw.
“Hair loss profoundly affects many people’s lives. A significant part of my practice involves both men and women who are seeking solutions to their hair loss,” says Richard Chaffoo, M.D., F.A.C.S., a triple board-certified plastic surgeon who founded La Jolla Hair MD and is a medical adviser to Stemson Therapeutics. “I am eager to advance this groundbreaking technology, which could improve the lives of millions of people who struggle with hair loss.”
The technology was discovered and developed at Sanford Burnham Prebys. Further development and commercialization activities will be conducted by Stemson Therapeutics. For updates on the technology’s progress and advancement, please visit www.stemsontx.com.
Learn more: Functional hair follicles grown from stem cells
The Latest on: Induced pluripotent stem cells
via Google News
The Latest on: Induced pluripotent stem cells
- VERIFY: Was the antibody cocktail used to treat President Trump developed using human embryonic stem cells?on October 7, 2020 at 6:51 pm
Social media is buzzing with the claim President Trump, who is pro-life, used an antibody cocktail developed using human embryonic stem cells.
- The Global Stem Cell Therapy Market Growth To 2023 Will Be Driven By Increasing Prevalence Of Chronic Diseaseson October 6, 2020 at 8:38 pm
"Global Stem Cell Therapy Market, Forecast Market Size, 2019 – 2023, $ Billion" The Business Research Company’s Global Stem Cell Therapy Market Report 2020-30: Covid 19 Growth And Change; Segments ...
- Terahertz zaps alter gene activity in stem cellson October 5, 2020 at 4:38 am
Terahertz light pulses change gene expression in stem cells, report researchers from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and Tokai University in Japan in the ...
- Stem cell studies probe origins of the placentaon October 1, 2020 at 9:29 pm
They have found a method of “reprogramming” adult cells, reverting them to a primitive state, that can prompt them to become trophoblast stem cells (TSCs), which give rise to placental cells. The ...
- Stem cell discovery may lead to new treatments for placenta complicationson September 28, 2020 at 10:04 am
A new way to create stem cells that are able to produce placenta tissue has been discovered, potentially leading to new treatments for placenta complications that may arise during pregnancy. A ...
- Induced Pluripotent Stem Cells (iPSCs) Market to Witness Growth at 12.7% CAGR by 2025on September 23, 2020 at 3:45 pm
Sep 23, 2020 (Market Insight Reports) -- Selbyville, Delaware, The ‘ Induced Pluripotent Stem Cells (iPSCs) market’ research added by Market Study Report, LLC, is essentially an exhaustive ...
- A new discovery in pluripotent stem cells and induced regenerative medicineon September 15, 2020 at 5:00 pm
It was during the study of this process that they discovered a new way to create induced trophoblast stem cells (iTSCs) that can be used to make placenta cells. This exciting discovery ...
- In a world first, reprogrammed stem cells used to treat immune diseaseon September 15, 2020 at 2:30 am
The Sydney doctor who led the study said this was the first step towards being able to use engineered cells to treat a host of conditions.
- Researchers find a way to help stem cells work for the hearton September 10, 2020 at 3:32 pm
Testing a two-step stem cell treatment Chiamvimonvat and her team tested that theory in mice using cardiac muscle cells known as cardiomyocytes, which were derived from human-induced pluripotent ...
- Lineage Cell Therapeutics and AgeX Therapeutics Announce Expansion of Agreement Related to ESI Clinical-Grade Pluripotent Stem Cell Lines for Therapeutic Purposeson September 9, 2020 at 5:29 am
AgeX’s revolutionary longevity platform induced Tissue Regeneration (iTR ... such risks include those associated with the use of human pluripotent stem cell lines in the research, development ...
via Bing News