Close analysis of EEG data reveals that nearly 1 in 7 brain-injured ICU patients shows evidence of hidden consciousness just days after injury. Patients with such signs are more likely to recover, neurologists at Columbia University and NewYork-Presbyterian have found.
In the study, the researchers used a machine learning technique to analyze standard EEG data collected from 104 unresponsive patients to look for patient-specific brain activity indicating that they could understand instructions to move their hands. If the findings are confirmed in larger studies, the technique could help physicians better predict which patients will likely regain consciousness.
“Though our study was small, it suggests that EEG—a tool that’s readily available at the patient’s bedside in the ICU in almost any hospital across the globe—has the potential to completely change how we manage patients with acute brain injury,” says Jan Claassen, MD, PhD, associate professor of neurology at Columbia University Vagelos College of Physicians and Surgeons, lead author of the study, and director of the Neurological Intensive Care Unit at NewYork-Presbyterian/Columbia University Irving Medical Center.
The findings were published today in the New England Journal of Medicine.
Why It’s Important
Currently, there’s no perfect way to accurately predict the chance of recovery for unconscious, brain-injured patients.
Electroencephalography (EEG) is commonly used in intensive care to monitor critically ill patients at risk for seizures and may be a relatively easy and fast way to identify signs of hidden consciousness in unresponsive patients who have recently experienced brain injury.
Difficult discussions between families and health care providers determine the intensity of medical support for unresponsive patients. The decision to withdraw life-sustaining therapies from patients who appear to have little chance to recover are frequently made within the first weeks following brain injury.
Clinicians use bedside neurological examinations, imaging and electrophysiological studies, and laboratory values to estimate the likelihood of recovery for people who are unresponsive in the days and weeks after sustaining a brain injury. However, these predictions are frequently inaccurate.
Increasingly, however, studies suggest that some unresponsive patients may have hidden cognitive abilities and that delayed recovery is more common than previously thought.
Hidden consciousness was first identified over a decade ago using MRI in a brain-injured patient who had been unresponsive for years. Since then, studies using MRI or EEG have detected signs of hidden consciousness in 14% of chronically unresponsive patients. But MRI is challenging to perform in a critical care setting.
“One of the most challenging problems in the ICU involves predicting recovery, and not just survival, for patients who are unconscious after a brain injury,” says Claassen. “Since the first studies describing hidden consciousness, we’ve been looking for a practical way to do this in the early days after brain injury, when treatment decisions that affect outcomes are often made.”
What the Researchers Did
Claassen and his team studied 104 adult patients in an intensive care unit who had recently sustained a sudden brain injury due to hemorrhage, trauma, or oxygen deprivation. Though none of the patients were paralyzed, they were unable to talk and did not respond to commands to move (e.g., make a fist or wiggle their toes).
Every day, in addition to standard neurological exams, the patients were asked multiple times to open and close their hands or stop opening and closing their hands. A complex algorithm was used to analyze EEG data from these sessions to look for signs that a patient detected a difference between the commands. A reproducibly different pattern of activity between the commands suggested that a patient was able to understand the command but could not perform the movement.
The researchers followed up with patients who were discharged from the hospital a year later.
What the Study Found
Within four days of the injury, 15% of the still-unresponsive patients had brain activity patterns on at least one EEG recording, suggesting hidden consciousness. Among the patients with these patterns, 50% improved and were able to follow verbal commands before being discharged from the hospital versus 26% of those without such brain activity.
A year later, 44% of patients with brain activity patterns were able to function independently for up to eight hours each day, compared with only 14% of those without such signals. Approximately one-third of patients in each group—those with early EEG evidence of hidden consciousness and those without—died.
Hidden consciousness signals were also more common in patients with brain injuries from hemorrhage and trauma than from oxygen deprivation. However, the study lacked sufficient statistical power to determine the predictive value of EEG analysis across different causes of brain injury.
“This study shows that some patients who are unresponsive for days or longer may have cognitive processing capabilities sufficient to distinguish commands, and those patients have a higher chance of recovering,” says Claassen.
Bigger studies—especially in patients with a single cause of brain injury—are needed to determine the utility of EEG monitoring in predicting patient outcomes.
There are some technical challenges with EEG monitoring: Neurological exams must be performed at least once or twice a day as consciousness fluctuates after a brain injury; spoken commands must be highly synchronized with EEG recordings; and additional computers are needed to do the analysis.
“It’s important to begin monitoring with EEG as early as possible and to assess at several time points as recovery after a severe brain injury is a complex process,” Claassen says.
Most importantly, he says, these assessments have to be designed meticulously because artifacts may be misinterpreted as brain activation if the testing paradigm is poorly designed or the computational analysis is applied incorrectly.
The Latest on: Brain injury
via Google News
The Latest on: Brain injury
- Student who overcame brain injury crowned homecoming kingon October 13, 2019 at 9:31 pm
NEWCASTLE, Okla. — Caleb Freeman was once the fastest runner at his Oklahoma high school. But after a car accident left him with a traumatic brain injury, he was told he might never run again. This ...
- Boxer Patrick Day in coma after suffering brain injury, manager sayson October 13, 2019 at 9:09 pm
CHICAGO — Boxer Patrick Day suffered a traumatic brain injury and is in extremely critical condition in a coma caused by the injury sustained in a bout, his manager said Sunday. Lou DiBella says in a ...
- Patrick Day in coma after brain injury during Saturday fighton October 13, 2019 at 8:08 pm
CHICAGO (AP) Boxer Patrick Day suffered a traumatic brain injury and is in extremely critical condition in a coma caused by the injury sustained in a bout, his manager said Sunday. Lou DiBella says in ...
- Manager: Boxer Day in coma after suffering brain injuryon October 13, 2019 at 7:12 pm
CHICAGO (AP) — The manager of Patrick Day says the boxer has suffered a traumatic brain injury and is in extremely critical condition in a coma caused by the injury during a bout. Lou DiBella says in ...
- High school runner who overcame brain injury crowned homecoming kingon October 13, 2019 at 7:10 pm
(CNN) - Caleb Freeman was once the fastest runner at his Oklahoma high school. But after a car accident left him with a traumatic brain injury, he was told he might never run again. This week, the ...
- A high school runner who overcame a traumatic brain injury is crowned homecoming kingon October 13, 2019 at 5:10 pm
(CNN)Caleb Freeman was once the fastest runner at his Oklahoma high school. But after a car accident left him with a traumatic brain injury, he was told he might never run again. This week, the former ...
- Newcastle track star who overcame brain injury crowned Homecoming Kingon October 13, 2019 at 12:59 pm
NEWCASTLE, Okla. – A Newcastle High School track star who overcame traumatic brain injury is now high school royalty. Caleb Freeman was voted Newcastle’s Homecoming King on Friday night. The honor is ...
- Manager: Boxer Patrick Day in coma after suffering traumatic brain injury during Chicago fighton October 13, 2019 at 7:21 am
Boxer Patrick Day suffered a traumatic brain injury and is in extremely critical condition in a coma caused by the injury, his manager said Sunday. Lou DiBella says in a posting on his website that ...
- Football little league lets boy with brain injuries score touchdownon October 12, 2019 at 7:45 pm
There was a big win on Rocky Top Saturday on the little league football field. Brayden Yawn got to carry the ball for the JV Hoppers Little League Football Team for the very first time. Brayden was ...
- St. Charles North football team dedicates Friday game to teammate with brain injuryon October 12, 2019 at 1:25 am
Aidan Carlson's teammates at St. Charles North High School are playing in honor of the sophomore one week after he suffered a brain injury during a game. Aidan's family, as well as dozens of ...
via Bing News