Non-pharmaceutical treatment combats recurring Clostridium Difficile infections
Transplanting human donor fecal microbiota into the colon of a patient infected with Clostridiodes difficile (C. diff) may be the best treatment for those not helped by C. diff targeted antibiotics, according to an article in the Journal of the American Osteopathic Association.
C. diff is the most common healthcare-acquired infection in the United States. It affects nearly half a million patients each year and becomes a recurring infection for nearly a third of them. If untreated, C. diff can lead to sepsis and death.
“Twenty five years ago C. diff infections were easier to manage and often resolved with discontinuation of the initiating antibiotic,” says Robert Orenstein, DO, an infectious disease specialist at Mayo Clinic and lead author on this article. “However, these infections have become increasingly common and pernicious.”
The standard and FDA-approved treatment for C. diff is a course of oral vancomycin, an antibiotic. However, even the medications used to eliminate C. diff can perpetuate the infection by killing off beneficial microbes. Newer antibiotics that more specifically target C. diff have been developed but they can be prohibitively expensive, according to Dr. Orenstein.
“Think of your gut as a forest and C. diff as a weed,” says Dr. Orenstein. “In a thriving forest, weeds barely get a foothold. But if you burn the forest down, the weeds are going to flourish.”
Unlike antibiotics, which are destructive by definition, fecal transplants or microbial replacement therapies, repopulate the gut with a diverse group of microbes that may block the C. diff‘s spore from germinating and propagating disease via its toxins. Transplants have several delivery methods, including enemas, capsules and direct instillation, to replace the diverse flora that maintain health and improve metabolism.
Currently, there are no FDA-approved fecal transplant products and performing fecal transplants is considered an investigational procedure. Dr. Orenstein notes there are several companies with products in Phase 3 clinical trials that could come to market as early as 2020. For this reason he strongly urges healthcare providers to refer patients with recurrent C. diff for these trials rather than for fecal transplants. In the meantime, the FDA reserves fecal transplants for patients who have experienced a second recurrence (third episode) of C. diff infection.
C. diff is common in healthcare settings and public spaces and rarely causes problems in people with healthy gut microbiota and immune systems, according to researchers. However, people who are already ill and taking antibiotics, chemotherapy, or proton pump inhibitors–which all greatly disrupt the gut ecosystem–are at risk. Elderly patients are especially vulnerable.
Dr. Orenstein expects the new treatment options will improve outcomes but says physicians need to assume greater responsibility for prevention.
“One of the most effective things physicians can do is become more responsible with antibiotic prescriptions,” says Dr. Orenstein. “That means only prescribing when they are clearly indicated, not for colds or viral sinus infections. We also must be especially judicious with elderly patients.”
The Latest on: Fecal transplants
via Google News
The Latest on: Fecal transplants
- Improving age-related cognition may rest on a fecal transplanton October 7, 2020 at 8:39 am
Improving age-related cognition and the decline that comes with old age is something many medical professionals aspire to. There could be an answer, according to a new study, based on fecal transplant ...
- Alzheimer’s Patient Recalls Daughter’s Birthday After Undergoing Fecal Transplanton October 7, 2020 at 5:28 am
Dr. Sabine Hazan, founder of ProgenaBiome, a genetic sequencing lab in California, achieved rapid improvement in Alzheimer's disease (AD) symptoms in an 82-year-old male patient following fecal ...
- Fecal transplant may be used to reverse cognitive decline: Studyon October 4, 2020 at 9:12 am
In a unique study, researchers have found that faecal transplants could one day be used to reverse the cognitive decline that comes with ageing.
- Fecal microbiota transplantation restores gut microbial development in cesarean-born infantson October 3, 2020 at 8:22 pm
The human gut contains a diverse ecosystem of microbes: mainly bacteria, as well as viruses and fungi, termed the gut microbiota. Recent years have shown that the gut microbiota have widespread ...
- New evidence links age-related cognitive decline & the gut microbiomeon October 3, 2020 at 5:00 pm
Scientists from the UK and Italy have found fecal transplants from old mice to young mice result in the younger animals displaying learning and memory impairments. The findings build on a growing body ...
- Fecal transplants may be the ‘fountain of youth’ for cognitive functionon October 3, 2020 at 8:52 am
Fecal transplants may be the ‘fountain of youth’ of cognitive function, researchers with the University of East Anglia have announced. The procedure, which is commonly used to treat C.
- Could a fecal transplant one day be the secret of eternal youth?on October 2, 2020 at 3:47 pm
Fecal transplants could one day be used to restore cognitive decline among the elderly - according to new research. A new study shows how fecal transplants from older to younger mice altered their gut ...
- Study: Fecal transplant may one day be used to reverse cognitive declineon October 2, 2020 at 3:19 pm
New research suggests fecal transplants could one day be used to reverse the cognitive decline that comes with aging.
- Could a poo transplant one day be the secret of eternal youth?on October 2, 2020 at 4:24 am
Fecal transplants could one day be used as a therapy to restore cognitive function in the elderly—according to new research from the University of East Anglia, the University of Florence and the ...
- New AGA report details effectiveness and safety of fecal microbiota transplantationon October 1, 2020 at 5:12 pm
Today, the American Gastroenterological Association released the first results from the NIH-funded AGA Fecal Microbiota Transplantation National Registry, the largest real-world study on the safety ...
via Bing News