A simple innovation the size of a grain of sand means we can now analyse cells and tiny particles as if they were inside the human body.
The new micro-device for fluid analysis will enable more tailored experiments in drug development and disease research.
It could also transform water contamination testing and medical diagnosis in natural disaster zones, where its low cost, simple use and portability make it a practical tool almost anyone can use.
How it works
Microfluidic or ‘lab-on-a-chip’ devices are commonly used to analyse blood and other fluid samples, which are pumped through narrow channels in a transparent chip the size of a postage stamp.
These miniaturised chips are made using state-of-the-art device fabrication facilities at RMIT’s Micro Nano Research Facility.
This new chip takes that technology one step further by adding a three-dimensional cavity along the channel – think of a narrow tunnel that suddenly opens into a domed vault – which creates a mini-vortex where particles spin around, making them easier to observe.
To make this cavity, researchers inserted a liquid metal drop onto the silicon mould when making the chip.
The liquid metal’s high surface tension means it holds its form during the moulding process.
Finally the liquid metal is removed, leaving just the channel and a spherical cavity ready to use as a mini-centrifuge, explained RMIT engineer and study co-leader Dr Khashayar Khoshmanesh.
“When the fluid sample enters the spherical-shaped cavity, it spins inside the cavity,” he said.
“This spinning creates a natural vortex, which just like a centrifuge machine in an analytics lab, spins the cells or other biological samples, allowing them to be studied without the need for capturing or labelling them.”
The device only requires tiny samples, as little as 1 ml of water or blood, and can be used to study tiny bacterial cells measuring just 1 micron, all the way up to human cells as large as 15 microns.
A platform for studying cardiovascular diseases
Study co-leader and RMIT Postdoctoral Research Fellow, Dr Sara Baratchi, said the device’s soft spherical cavities could be used to mimic 3D human organs and observe how cells behave in various flow conditions or drug interactions.
“The ability to tailor the size of the cavity also allows for different flow situations to be simulated – this way we can mimic the response of blood cells under disturbed flow situations, for example at branch points and curvatures of coronary and carotid arteries, which are more prone to narrowing,” she said.
This capability will be of interest to Australia’s booming biomedical industry, with medical apparatus being among our top 10 exports in 2018 and worth $3.2 billion.
Baratchi said the discovery was only made possible through collaboration, with technologists from the School of Engineering and mechano-biologists in the School of Health and Biomedical Sciences joining forces in RMIT’s Mechanobiology and Microfluidics research group.
“Biologists like myself have been struggling to study the impact of flow-associated forces on circulatory blood cells. Now this miniaturised device developed with our engineering colleagues does exactly that,” Baratchi said.
“It’s an ingenious solution that really highlights the value of cross-disciplinary research.”
But some of the most exciting applications could also be outside the lab.
A cheap and portable water test that anyone can use
Another promising application is for identifying parasites and other infections in waterways, especially in developing countries.
“Detection of water impurities can be a difficult task because you don’t always know exactly what you’re looking for,” Khoshmanesh said.
“But with this device the impurities will be captured and orbited by the vortex without any special sample preparation, saving time and money.”
Whether used for analysing water or blood samples, the low cost and portability of the device makes it attractive for a whole range of applications.
The same research group recently developed a pressure pump, made from latex balloons, to operate the device.
Unlike conventional pumps, which can be as large as a shoebox and cost thousands of dollars, theirs is low cost and portable.
“Simplicity is a very important parameter for our designs because that often translates to lower cost and great applicability outside the lab,” Khoshmanesh said.
“Our new microfluidic device, combined with our pump and a smartphone capable of capturing high-speed images, makes a low-cost, self-sufficient and entirely portable point-of-care diagnostics device.”
The Latest on: Point-of-care diagnostics device
via Google News
The Latest on: Point-of-care diagnostics device
- 20/20 Launching First COVID-19 Rapid Antibody Test Authorized by FDA for Point-of-Care Useon October 7, 2020 at 7:05 am
BioResponse, a business unit of 20/20 GeneSystems, Inc., announced today that it is now accepting orders for the Assure COVID-19 IgG/IgM Rapid Test kits. These kits were the first to receive an ...
- Point of Care (PoC) Diagnostics Market Size, Share Set to Register 34.6 billion USD by 2025 - Industry Newson October 6, 2020 at 3:33 pm
Diagnostics Market Size and Analysis maintains enhanced dynamics and is overshadowed by a top player across the globe. The research report provides Point of Care (PoC) Diagnostics Market Growth and ...
- BD Gets CE Mark for Point-of-Care Coronavirus Antigen Teston October 5, 2020 at 8:37 am
Becton, Dickinson and Company BDX — also popularly known as BD — recently received CE mark for its rapid, point-of-care, SARS-CoV-2 antigen test for utilization on the BD Veritor Plus System. The new ...
- Israeli PixCell Medical scores Australia Gov. approval for blood diagnostic device at point-of-careon October 5, 2020 at 4:03 am
The Israeli MedTech company receives approval from the Australian government, which deploys PixCell's diagnostics device as a COVID-19 remote care ...
- Worldwide Infectious Disease Point-of-Care Testing Industry to 2024 - Impact of the COVID-19 Pandemicon October 2, 2020 at 9:44 am
Based Solutions Spur the Global Infectious Disease Point-of-Care Testing Market, Forecast to 2024" report has been added to ResearchAndMarkets.com's offering.
- 7 Diagnostic and Genomic Stocks Storming Into Octoberon October 1, 2020 at 12:22 pm
I gave an update to my Healthcare Innovators members about our Top Ten stocks to buy now, or on pullbacks into October. And what I didn't anticipate was that immediately after in the week of Sep 21, ...
- How Chip Technology Can Help Diagnostics Manufacturerson September 29, 2020 at 5:00 pm
If you need a low-cost and convenient diagnostics device that can give you similar results as the ... which could be easily integrated in a point-of-care diagnostics. It is a generic technique and any ...
- Point-of-Care Diagnostics Devices And Equipment Global Market Report 2020-30: Covid 19 Implications and Growthon September 24, 2020 at 10:11 pm
Reportlinker.com announces the release of the report "Point-of-Care Diagnostics Devices And Equipment Global Market Report 2020-30: Covid 19 Implications and Growth" - 7 billion in 2019 to $21.5 ...
- Point-of-Care Diagnostics Devices And Equipment Global Market Report 2020-30: Covid 19 Implications and Growthon September 24, 2020 at 9:48 pm
New York, Sept. 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Point-of-Care Diagnostics Devices And Equipment Global Market Report 2020-30: Covid 19 ...
- Babson Diagnostics nets new CEO, plus $13.7M for its blood test deviceson September 24, 2020 at 1:00 pm
Babson Diagnostics, a startup looking to make widespread blood sample collection a simpler process, has closed its initial funding round of $13.7 million and gained a new CEO.
via Bing News