Engineered heart completely matches the immunological, cellular, biochemical and anatomical properties of the patient
In a major medical breakthrough, Tel Aviv University researchers have “printed” the world’s first 3D vascularised engineered heart using a patient’s own cells and biological materials. Their findings were published on April 15 in a study in Advanced Science.
Until now, scientists in regenerative medicine — a field positioned at the crossroads of biology and technology — have been successful in printing only simple tissues without blood vessels.
“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” says Prof. Tal Dvir of TAU’s School of Molecular Cell Biology and Biotechnology, Department of Materials Science and Engineering, Center for Nanoscience and Nanotechnology and Sagol Center for Regenerative Biotechnology, who led the research for the study.
Heart disease is the leading cause of death among both men and women in the United States. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the dire shortage of heart donors, the need to develop new approaches to regenerate the diseased heart is urgent.
“This heart is made from human cells and patient-specific biological materials. In our process these materials serve as the bioinks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models,” Prof. Dvir says. “People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future.”
Research for the study was conducted jointly by Prof. Dvir, Dr. Assaf Shapira of TAU’s Faculty of Life Sciences and Nadav Moor, a doctoral student in Prof. Dvir’s lab.
“At this stage, our 3D heart is small, the size of a rabbit’s heart,” explains Prof. Dvir. “But larger human hearts require the same technology.”
For the research, a biopsy of fatty tissue was taken from patients. The cellular and a-cellular materials of the tissue were then separated. While the cells were reprogrammed to become pluripotent stem cells, the extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules such as collagen and glycoproteins, were processed into a personalized hydrogel that served as the printing “ink.”
After being mixed with the hydrogel, the cells were efficiently differentiated to cardiac or endothelial cells to create patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart.
According to Prof. Dvir, the use of “native” patient-specific materials is crucial to successfully engineering tissues and organs.
“The biocompatibility of engineered materials is crucial to eliminating the risk of implant rejection, which jeopardizes the success of such treatments,” Prof. Dvir says. “Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient’s own tissues. Here, we can report a simple approach to 3D-printed thick, vascularized and perfusable cardiac tissues that completely match the immunological, cellular, biochemical and anatomical properties of the patient.”
The researchers are now planning on culturing the printed hearts in the lab and “teaching them to behave” like hearts, Prof. Dvir says. They then plan to transplant the 3D-printed heart in animal models.
“We need to develop the printed heart further,” he concludes. “The cells need to form a pumping ability; they can currently contract, but we need them to work together. Our hope is that we will succeed and prove our method’s efficacy and usefulness.
“Maybe, in ten years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely.”
The Latest on: 3D vascularised engineered heart
via Google News
The Latest on: 3D vascularised engineered heart
- 3D Printing A Real Hearton October 4, 2020 at 5:00 pm
One of the last breakthrough is the world’s first 3D vascularised engineered heart using the patient’s own cells and biological materials. Until now, scientists have only been successful in ...
- 3D Printing Helps Create Patch That Reduces Heart Failureon October 2, 2020 at 5:00 pm
A curated collection of industry and product deep-dives. Fried Vancraen is one of my favorite people in 3D printing. It was a pleasure working for him years ago, as well. I was therefore ...
- Scientists knit new artery grafts out of collagen and synthetic fiberson September 30, 2020 at 1:36 am
Heart attack patients often need replacements ... “That’s why we’re looking to use tissue-engineered vascular grafts.” The team combined two types of fibers into one hybrid yarn, and ...
- Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeuticson September 25, 2020 at 7:16 pm
Curi Bio Announces Mantarray Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics.
- X-Rays and Electron Beams Print 3D Soft Objects at High Resolutionon September 24, 2020 at 7:30 am
3D printing such materials could allow for custom implants, but has been hampered by poor resolution that impedes the types of fine structural details that would be useful in tissue engineered ...
- Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeuticson September 16, 2020 at 1:51 am
Curi Bio, a leading developer of human stem cell-based platforms for drug discovery, today announced the Mantarray™ platform for human-relevant 3D engineered muscle tissue (EMT) analysis.
- Generation of three-dimensional heart organoidson September 15, 2020 at 5:00 pm
Researchers engineered three-dimensional functional heart organoids resembling the developing heart. By exposing mouse embryonic stem cells to two key proteins during heart development ...
- Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeuticson September 15, 2020 at 9:06 am
Curi’s Platforms are Accelerating Drug Discovery with Human-Relevant 3D Engineered Muscle Tissue ... ultimately leading to heart failure. Cardiomyocytes derived from human induced pluripotent ...
- Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeuticson September 15, 2020 at 9:02 am
SEATTLE--(Business Wire)--Curi Bio, a leading developer of human stem cell-based platforms for drug discovery, today announced the Mantarray™ platform for human-relevant 3D engineered muscle ...
- 3D cluster of cells could enhance myocardial repairon September 14, 2020 at 5:00 pm
Now, a technique that combines three different types of cells in a 3D cluster could improve its efficacy in reducing scar tissue and improving cardiac function after a heart attack. Called ...
via Bing News