Research led by the Centenary Institute in Sydney has found a brand new target for treating drug resistant tuberculosis; our scientists have uncovered that the tuberculosis bacterium hijacks platelets from the body’s blood clotting system to weaken our immune systems.
Tuberculosis is far from eradicated around the world and still infects more than 1,400 people per year in Australia. Antibiotic resistant tuberculosis is particularly deadly and expensive to treat,
costing up to $250,000 to treat a single case in Australia. Scientists at the Centenary Institute have been working on new ways to treat tuberculosis by increasing the effectiveness of the immune
Using the zebrafish model of tuberculosis, the researchers used fluorescent microscopy to observe the build-up of clots and activation of platelets around sites of infection . Senior author and head of the Centenary’s Immune-Vascular Interactions laboratory, Dr Stefan Oehlers, says “the zebrafish gives us literal insight into disease processes by watching cells interacting in real time”.
Following their hunch that these platelets were being tricked by the infection into getting in the way of the body’s immune system, the researchers treated infections with anti-platelet drugs, including widely available aspirin, and were able to prevent hijacking and allow the body to control infection better.
Dr Elinor Hortle, lead author of the paper published in The Journal of Infectious Diseases, and Research Officer in Centenary’s Immune-Vascular Interactions laboratory says “This is the first
time that platelets have been found to worsen tuberculosis in an animal model. It opens up the possibility that anti-platelet drugs could be used to help the immune system fight off drug resistant
There are over 1.2 million Australians living with latent tuberculosis, a non-infectious form of TB that puts them at risk of developing the active disease. “Our study provides more crucial evidence
that widely available aspirin could be used to treat patients with severe tuberculosis infection and save lives,” says Dr Hortle.
Video 1 – Green platelets
zooming around the
vasculature of a zebrafish
embryo. Note some platelets
stick to red macrophages
infected by blue bacteria
Video 2 – Zoomed in version
of video 1 with visible blood
Green platelets sticking to
red blood vessels next to
sites of infection by blue
bacteria. Pathogenic platelets
are the green cells that stick
next to the bacteria for a few
The Latest on: Tuberculosis
via Google News
The Latest on: Tuberculosis
- Coronavirus Update: Tuberculosis vaccine being tested in Canada for effectiveness against COVID-19on October 6, 2020 at 4:41 pm
Donald Trump continues to play down severity of virus while still infected; First antigen rapid test for COVID-19 approved by Health Canada ...
- Prisoner contracts tuberculosison October 6, 2020 at 10:56 am
"Unfortunately, medical information is not readily given out to staff, and it's a concern of ours that somebody comes in with something transferrable via the atmosphere, and we don't know about it ...
- Canadian researchers begin clinical trials of tuberculosis vaccine for COVID-19on October 6, 2020 at 7:09 am
Researchers in Canada are hoping a century-old vaccine designed to treat tuberculosis can become the key to fighting off a COVID-19 infection.
- Atomwise Receives a $2.3M Grant to Develop New Therapies for Drug Resistant Malaria and Tuberculosison October 6, 2020 at 6:14 am
The $2.3M in grant funding from the Bill & Melinda Gates Foundation will support the development of multiple global health programs to advance novel antimalarial and anti-tuberculosis small molecule ...
- Tuberculosis found in Waikato's Spring Hill prisonon October 5, 2020 at 8:37 pm
There is at least one case of tuberculosis, known as TB, in the Spring Hill prison in North Waikato. Spring Hill Prison director Megan Tuhoro said the secure and controlled nature of the prison ...
- Vaccine for tuberculosis being tested in Canada for effectiveness against COVID-19on October 5, 2020 at 5:56 pm
Researchers suspect the vaccine, known as BCG, primes the body in a general way and enhances its ability to seek out and destroy virus-infected cells ...
- Tuberculosis, still a threat to Filipino childrenon October 4, 2020 at 8:51 pm
Through the campaign #TBFreePH, the Department of Health (DOH) with the help of the United States Agency International Development (USAID) under TB Innovations and Health Systems Strengthening Project ...
- Kwara First Lady partners stakeholders on tuberculosis eradicationon October 1, 2020 at 6:36 am
Mrs Olufolake AbdulRazaq has appealed to stakeholders to support the State Government’s efforts at eradicating Tuberculosis (TB) in the state.
- How Toronto’s first open-air school responded to the tuberculosis crisis more than 100 years agoon September 30, 2020 at 5:29 pm
The third-floor blueprints of Orde Street Public School show several open-air classrooms and an accessible rooftop classroom which remains open to the elements to this day.
- Latent Tuberculosis Infection (LTBI) Testing Market Will Expand at 5.6% CAGR to Cross $ 1540 million by 2025on September 30, 2020 at 9:02 am
Selbyville, Delaware, The ‘ Latent Tuberculosis Infection (LTBI) Testing market’ research report now available ...
via Bing News