Imagine a day when a bioprinter filled with a patient’s own cells can be wheeled right to the bedside to treat large wounds or burns by printing skin, layer by layer, to begin the healing process. That day is not far off.
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created such a mobile skin bioprinting system – the first of its kind – that allows bi-layered skin to be printed directly into a wound.
“The unique aspect of this technology is the mobility of the system and the ability to provide on-site management of extensive wounds by scanning and measuring them in order to deposit the cells directly where they are needed to create skin,” said Sean Murphy, PhD, a WFIRM assistant professor who was lead author of the paper published this month in Nature’s Scientific Reports journal.
Affecting millions of Americans, chronic, large or non-healing wounds such as diabetic pressure ulcers are especially costly because they often require multiple treatments. It is also estimated that burn injuries account for 10-30 percent of combat casualties in conventional warfare for military personnel.
The major skin cells – dermal fibroblasts and epidermal keratinocytes – are easily isolated from a small biopsy of uninjured tissue and expanded. Fibroblasts are cells that synthesize the extracellular matrix and collagen that play a critical role in wound healing while keratinocytes are the predominant cells found in the epidermis, the outermost layer of the skin.
The cells are mixed into a hydrogel and placed into the bioprinter. Integrated imaging technology involving a device that scans the wound, feeds the data into the software to tell the print heads which cells to deliver exactly where in the wound layer by layer. The bioprinter deposits the cells directly into the wound, replicating the layered skin structure, and accelerating the formation of normal skin structure and function.
The researchers demonstrated proof-of-concept of the system by printing skin directly onto pre-clinical models.
The next step is to conduct a clinical trial in humans. Currently, skin grafts to treat wounds and burns are the “gold standard” technique, but adequate coverage of wounds is often a challenge particularly when there is limited availability of healthy skin to harvest. Skin grafts from donors are an option, but risk immune rejection of the graft and scar formation. With the WFIRM bioprinter system the researchers could see new skin forming outward from the center of the wound and this only happened when the patient’s own cells were used, because the tissues were accepted and not rejected.
“The technology has the potential to eliminate the need for painful skin grafts that cause further disfigurement for patients suffering from large wounds or burns,” said WFIRM Director Anthony Atala, MD, and a co-author of the paper. “A mobile bioprinter that can provide on-site management of extensive wounds could help to accelerate the delivery of care and decrease costs for patients.”
“If you deliver the patient’s own cells, they do actively contribute to wound healing by organizing up front to start the healing process much faster,” said James Yoo, MD, PhD, who led the research team and co-authored the paper. “While there are other types of wound healing products available to treat wounds and help them close, those products do not actually contribute directly to the creation of skin.”
Learn more: Mobile Bedside Bioprinter Can Heal Wounds
The Latest on: Skin bioprinting system
via Google News
The Latest on: Skin bioprinting system
- New Process can 3D Print Living Cells with Precision and Speedon September 28, 2020 at 5:00 pm
3D bioprinting has come a long way in recent years, with scientists using living tissue to print organs as complex as human skin. Researchers in Austria have unveiled an advancement with a process ...
- 3D printing is making a giant leap into health. That could change everythingon September 28, 2020 at 3:51 am
People with transplanted organs also need to take medication to suppress their immune system long ... can be created by bioprinting, for that matter. Flat tissues, like skin, and hollow ones ...
- 3-D Printing inside the Body Could Patch Stomach Ulcerson September 22, 2020 at 4:21 am
Stomach ulcers and other gastric wounds afflict one in eight people worldwide, but common conventional therapies have drawbacks. Now scientists aim to treat such problems by exploring a new frontier ...
- Scientists 3D Print Shark Skin: May lead to technologically advanced boat propellers & moreon September 11, 2020 at 5:00 pm
A curated collection of industry and product deep-dives. In this episode, Max and I spoke with Eric Pallarés of BCN3D. BCN3D is a Barcelona-based material extrusion 3D printing company. Having ...
- 3D Bioprinting Market Worth $4735.96 Million, Globally, by 2027 at 26.43% CAGR Verified Market Researchon September 10, 2020 at 6:29 am
The major technological advancements in the 3D bioprinting space have taken place for various medical applications, including skin tissue development, cancer therapeutics, bone and cartilage ...
- 3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regenerationon September 9, 2020 at 12:05 pm
Different joint tissue constructs for joint reconstruction were fabricated using 3D bioprinting as previously reported with organ printing united system (OPUS ... were transplanted under the dorsal ...
- CollPlant Biotechnologies to Present at Science of Aging Virtual Symposium 2020 During Healthy Aging Monthon August 31, 2020 at 4:07 am
About CollPlant CollPlant is a regenerative and aesthetic medicine company focused on 3D bioprinting of tissues and organs, and medical aesthetics. Our products are based on our rhCollagen ...
- Ricoh to Buy 34.5 Percent of Bioprinting Company Elixirgen Scientificon August 29, 2020 at 5:00 pm
A curated collection of industry and product deep-dives. I’ve known Alexander Oster a long time now. He joined FIT at 16 to work on making a printer and later writing code for the leading ...
- 3D Bioprinting Just Took A Major Step Forwardon February 15, 2016 at 12:22 pm
Credit: Wake Forest Institute for Regenerative Medicine The new bioprinting system overcomes each of these ... Human-sized external ears were implanted under the skin of mice.
via Bing News