Led by researchers at RCSI (Royal College of Surgeons in Ireland), a team of researchers has developed a new treatment for tuberculosis (TB). This work could offer a practical treatment that has the potential to be scaled-up and mass-produced for clinical testing.
The treatment, which patients will take using an inhaler, works by reducing the bacteria in the lungs that causes tuberculosis while also helping the patient’s immune system fight the disease.
There is only one vaccine for tuberculosis, developed in 1921. It is unreliable in preventing the most common form of TB, and is not suitable in all patient groups. The vaccine works best against specific forms of TB and is usually given to infants in at-risk populations.
Tuberculosis is one of the top 10 causes of death worldwide. The World Health Organization (WHO) data show that 10 million people fell ill with TB and 1.6 million died from the disease in 2017. WHO estimates that there were 558,000 new cases with resistance to the most effective first-line antibiotic. Of those resistant to the drug, 82% were resistant to multiple antibiotics.
Funded by the Health Research Board (HRB) and the Royal City of Dublin Hospital Trust, the research is published in the European Journal of Pharmaceutics & Biopharmaceutics.
The work, led by Dr Gemma O’Connor and Prof Sally-Ann Cryan in RCSI, was carried out in collaboration with research teams in St James Hospital, Trinity College Dublin and Imperial College London. Prof Joseph Keane and Dr Mary O’Sullivan led the team at St James Hospital and Trinity College Dublin with Dr Brian Robertson and Dr Nitya Krishnan leading the team at Imperial College London.
Multidrug-resistant TB (MDR-TB) is seen as both a public health crisis and a health security threat. Ending the TB epidemic by 2030 is listed among the health targets of the United Nations Sustainable Development Goals.
The pathogen that causes tuberculosis spreads by people breathing infected droplets into their lungs, where the disease can remain dormant or spread further. The research makes use of a derivative of Vitamin A called all trans retinoic acid, atRA, which previous studies have shown is an effective treatment for tuberculosis.
“Many cases of TB are now becoming resistant to existing antibiotics. This new treatment could be used alongside antibiotics to treat drug-resistant TB and also possibly reduce the rate of antibiotic resistance resulting from conventional antibiotic treatments,” said Prof Cryan, Associate Professor of Pharmaceutics in RCSI School of Pharmacy and the study’s senior author.
Using a spray-drying process, the researchers packaged atRA within safe-for-consumption particles that are small enough to use in an inhaler. These particles efficiently delivered the treatment and significantly reduced tuberculosis-causing bacteria and associated lung damage, which supports their potential for clinical testing.
“Unfortunately, tuberculosis remains a significant problem for world health. We urgently need innovative treatments like this one if we are to achieve the UN 2030 health targets,” said Prof Keane, Professor at Trinity College Dublin School of Medicine and Consultant Respiratory Physician in St James’s Hospital.
The Latest on: Tuberculosis
via Google News
The Latest on: Tuberculosis
SIUT conducts anti-tuberculosis campaign in Malir
on March 26, 2019 at 2:11 am
KARACHI: The Sindh Institute of Urology and Transplantation (SIUT) conducted an anti-tuberculosis campaign at its primary healthcare centre at Kathore, Malir, to raise awareness about the deadly ... […]
Nigeria: Health Minister, Experts Decry Rising Cases of Tuberculosis in Nigeria
on March 25, 2019 at 11:29 pm
Abuja — Minister of Health, Professor Isaac Adewole, as well as local and international medical experts have expressed concern over rising cases of Tuberculosis (TB) in Nigeria, especially among ... […]
Aspirin could be used to treat patients with severe tuberculosis infection
on March 25, 2019 at 11:08 pm
Research led by the Centenary Institute in Sydney has found a brand new target for treating drug-resistant tuberculosis; our scientists have uncovered that the tuberculosis bacterium hijacks platelets ... […]
Building tuberculosis awareness in low-risk countries
on March 25, 2019 at 4:48 am
Tuberculosis specialists carry out monthly visits to review cases and distribute medication in clinics in the South Fly District, Papua New Guinea. Photo by: DFAT / CC BY “There is inadequate funding ... […]
Nigeria: Tuberculosis Spreading, Becoming Untreatable in Nigeria, Experts Warn
on March 25, 2019 at 12:38 am
Medical experts have warned of the spread of the untreatable variant of tuberculosis (TB) in Nigeria. As part of activities to mark the World Tuberculosis Day (WTD) today, they alerted the ... […]
Shaping new treatments for tuberculosis
on March 24, 2019 at 9:49 pm
To commemorate World TB Day, a Special Collection has been released by PLOS Medicine containing a series of articles that articulate the essential new steps in clinical research that will pave the way ... […]
India should heed a teenager’s historic fight for lifesaving tuberculosis treatment
on March 24, 2019 at 4:12 am
Malala Yousafzai and Greta Thunberg have shown us the formidable power of a single adolescent girl with determination. Shreya Tripathi of India, who didn’t live to see her 20th birthday, belongs with ... […]
Ending tuberculosis: we can get there with a new roadmap
on March 24, 2019 at 4:08 am
Two recent events have nudged tuberculosis, the leading infectious cause of death around the word, onto the world stage. The first was the World Health Organization’s Global Ministerial Conference on ... […]
A Painless Microneedle Patch For Diagnosing Tuberculosis
on March 24, 2019 at 3:06 am
March 24 is World TB Day—an occasion to galvanize more attention to an unnecessarily persistent disease. Tuberculosis is chronically overlooked. Fully one-quarter of the world’s population is infected ... […]
It's time to #EndTB, says UN on World Tuberculosis Day
on March 24, 2019 at 1:25 am
TB remains the worlds deadliest infectious killer, claiming nearly 4,500 lives each year and afflicting close to 30,000 others according to the World Health Organization (WHO). Since 2000, global ... […]
via Bing News